|Vitamin E regulation.
|Year of Publication
|Curr Opin Gastroenterol
|Animals, Carrier Proteins, Chromans, Humans, Protein Binding, Protein Conformation, Receptors, Cytoplasmic and Nuclear, Vitamin E, Vitamin E Deficiency, Xenobiotics
PURPOSE OF REVIEW: Vitamin E deficiency in humans has lead to the discovery of regulatory mechanisms that control plasma alpha-tocopherol concentrations and prevent the accumulation of other molecules with vitamin E-antioxidant activity, such as gamma-tocopherol. This review describes these regulatory mechanisms.
RECENT FINDINGS: alpha-tocopherol regulatory proteins have been cloned and crystallized and their mechanisms of action are under intense scrutiny. Studies of vitamin E metabolism suggest that xenobiotic metabolism may not only regulate vitamin E concentrations, but that vitamin E may regulate xenobiotic clearance pathways.
SUMMARY: Advances in our understanding of vitamin E nutrition suggest that vitamin E is a potent molecule that is closely regulated such that alpha-tocopherol is at the appropriate tissue concentrations necessary for some as yet to be described functions.
|Curr. Opin. Gastroenterol.