TitleVitamin E regulation.
Publication TypeJournal Article
Year of Publication2005
AuthorsTraber MG
JournalCurr Opin Gastroenterol
Date Published2005 Mar
KeywordsAnimals, Carrier Proteins, Chromans, Humans, Protein Binding, Protein Conformation, Receptors, Cytoplasmic and Nuclear, Vitamin E, Vitamin E Deficiency, Xenobiotics

PURPOSE OF REVIEW: Vitamin E deficiency in humans has lead to the discovery of regulatory mechanisms that control plasma alpha-tocopherol concentrations and prevent the accumulation of other molecules with vitamin E-antioxidant activity, such as gamma-tocopherol. This review describes these regulatory mechanisms.

RECENT FINDINGS: alpha-tocopherol regulatory proteins have been cloned and crystallized and their mechanisms of action are under intense scrutiny. Studies of vitamin E metabolism suggest that xenobiotic metabolism may not only regulate vitamin E concentrations, but that vitamin E may regulate xenobiotic clearance pathways.

SUMMARY: Advances in our understanding of vitamin E nutrition suggest that vitamin E is a potent molecule that is closely regulated such that alpha-tocopherol is at the appropriate tissue concentrations necessary for some as yet to be described functions.

Alternate JournalCurr. Opin. Gastroenterol.
PubMed ID15711217