TitleWhat Are the Major Physicochemical Factors in Determining the Preferential Nuclear Uptake of the DNA "Light-Switching" Ru(II)-Polypyridyl Complex in Live Cells via Ion-Pairing with Chlorophenolate Counter-Anions?
Publication TypeJournal Article
Year of Publication2019
AuthorsHuang R, Tang M, Huang C-H, Chao X-J, Yan Z-Y, Shao J, Zhu B-Z
JournalJ Phys Chem Lett
Volume10
Issue14
Pagination4123-4128
Date Published2019 Jul 18
ISSN1948-7185
KeywordsChemistry, Physical, Chlorophenols, Coordination Complexes, DNA, HeLa Cells, Humans, Ions, Molecular Structure, Polymers, Pyridines, Ruthenium
Abstract

Delivering potential theranostic metal complexes into preferential cellular targets is becoming of increasing interest. Here we report that nuclear uptake of a cell-impermeable DNA "light-switching" Ru(II)-polypyridyl complex can be significantly facilitated by chlorophenolate counter-anions, which was found, unexpectedly, to be correlated positively with the binding stability but inversely with the lipophilicity of the formed ion pairs.
DOI10.1021/acs.jpclett.9b01225
Alternate JournalJ Phys Chem Lett
PubMed ID31287699