Title Withania somnifera and Centella asiatica Extracts Ameliorate Behavioral Deficits in an In Vivo Drosophila melanogaster Model of Oxidative Stress.
Publication TypeJournal Article
Year of Publication2022
AuthorsCabey K, Long DM, Law A, Gray NE, McClure C, Caruso M, Lak P, Wright KM, Stevens JF, Maier CS, Soumyanath A, Kretzschmar D
JournalAntioxidants (Basel)
Date Published2022 Jan 06

Due to an increase in the aging population, age-related diseases and age-related changes, such as diminished cognition and sleep disturbances, are an increasing health threat. It has been suggested that an increase in oxidative stress underlies many of these changes. Current treatments for these diseases and changes either have low efficacy or have deleterious side effects preventing long-time use. Therefore, alternative treatments that promote healthy aging and provide resilience against these health threats are needed. The herbs and may be two such alternatives because both have been connected with reducing oxidative stress and could therefore ameliorate age-related impairments. To test the effects of these herbs on behavioral phenotypes induced by oxidative stress, we used the mutant which has high levels of oxidative stress due to reduced carbonyl reductase activity. Effects on cognition and mobility were assessed using phototaxis assays and both, and water extracts improved phototaxis in mutants. In addition, improved nighttime sleep in male and female flies and promoted a less fragmented sleep pattern in male flies. This suggests that and can ameliorate oxidative stress-related changes in behavior and that by doing so they might promote healthy aging in humans.

Alternate JournalAntioxidants (Basel)
PubMed ID35052625
PubMed Central IDPMC8773428
Grant ListU19 AT010829 / AT / NCCIH NIH HHS / United States
R01AT008099 / NH / NIH HHS / United States
U19AT010829 / NH / NIH HHS / United States
T32AT002688 / NH / NIH HHS / United States
T32 AT002688 / AT / NCCIH NIH HHS / United States