Linus Pauling Institute

Butler JA, Hagen TM, Moreau R.  2009.  Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion.. Arch Biochem Biophys. 485(1):63-71.

Moreau R, Heath S-HD, Doneanu CE, J Lindsay G, Hagen TM.  2003.  Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.. Antioxid Redox Signal. 5(5):517-27.

Suh JH, Heath S-H, Hagen TM.  2003.  Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress.. Free Radic Biol Med. 35(9):1064-72.

Michels AJ, Joisher N, Hagen TM.  2003.  Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes.. Arch Biochem Biophys. 410(1):112-20.

Keith DJ, Butler JA, Bemer B, Dixon B, Johnson S, Garrard M, Sudakin DL, J Christensen M, Pereira C, Hagen TM.  2012.  Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study.. Pharmacol Res. 66(3):199-206.

Moreau R, Nguyen BT, Doneanu CE, Hagen TM.  2005.  Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats.. Biochem Pharmacol. 69(1):29-40.

Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SKate, Frei B, Hagen TM.  2012.  R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.. Am J Physiol Regul Integr Comp Physiol. 302(5):R587-97.

Li L, Smith A, Hagen TM, Frei B.  2010.  Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.. Ann N Y Acad Sci. 1203:151-9.

Shay KPetersen, Hagen TM.  2009.  Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.. Biogerontology. 10(4):443-56.

Michels AJ, Butler JA, Uesugi SL, Lee K, Frei BB, Bobe G, Magnusson KR, Hagen TM.  2023.  Multivitamin/Multimineral Supplementation Prevents or Reverses Decline in Vitamin Biomarkers and Cellular Energy Metabolism in Healthy Older Men: A Randomized, Double-Blind, Placebo-Controlled Study.. Nutrients. 15(12)

Suh JH, Moreau R, Heath S-HD, Hagen TM.  2005.  Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.. Redox Rep. 10(1):52-60.

Smith EJ, Shay KP, Thomas NO, Butler JA, Finlay LF, Hagen TM.  2015.  Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a.. Free Radic Biol Med. 89:1184-91.

Thomas NO, Shay KP, Kelley AR, Butler JA, Hagen TM.  2016.  Glutathione maintenance mitigates age-related susceptibility to redox cycling agents.. Redox Biol. 10:45-52.

Gómez LA, Heath S-HD, Hagen TM.  2012.  Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.. Mech Ageing Dev. 133(2-3):99-106.

Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN.  2002.  Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.. Proc Natl Acad Sci U S A. 99(4):1870-5.

Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN.  2002.  Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.. Proc Natl Acad Sci U S A. 99(4):1870-5.

Zhang W-J, Bird KE, McMillen TS, Leboeuf RC, Hagen TM, Frei B.  2008.  Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice.. Circulation. 117(3):421-8.

Michels AJ, Butler JA, Uesugi SL, Lee K, Frei BB, Bobe G, Magnusson KR, Hagen TM.  2023.  Multivitamin/Multimineral Supplementation Prevents or Reverses Decline in Vitamin Biomarkers and Cellular Energy Metabolism in Healthy Older Men: A Randomized, Double-Blind, Placebo-Controlled Study.. Nutrients. 15(12)

Smith EJ, Shay KP, Thomas NO, Butler JA, Finlay LF, Hagen TM.  2015.  Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a.. Free Radic Biol Med. 89:1184-91.

Robinson KM, Janes MS, Pehar M, Monette JS, Ross MF, Hagen TM, Murphy MP, Beckman JS.  2006.  Selective fluorescent imaging of superoxide in vivo using ethidium-based probes.. Proc Natl Acad Sci U S A. 103(41):15038-43.

Dixon BM, Heath S-HD, Kim R, Suh JH, Hagen TM.  2008.  Assessment of endoplasmic reticulum glutathione redox status is confounded by extensive ex vivo oxidation.. Antioxid Redox Signal. 10(5):963-72.

Michels AJ, Butler JA, Uesugi SL, Lee K, Frei BB, Bobe G, Magnusson KR, Hagen TM.  2023.  Multivitamin/Multimineral Supplementation Prevents or Reverses Decline in Vitamin Biomarkers and Cellular Energy Metabolism in Healthy Older Men: A Randomized, Double-Blind, Placebo-Controlled Study.. Nutrients. 15(12)

Visioli F, Ingram A, Beckman JS, Magnusson KR, Hagen TM.  2022.  Strategies to protect against age-related mitochondrial decay: Do natural products and their derivatives help? Free Radic Biol Med. 178:330-346.

Robinson KM, Janes MS, Pehar M, Monette JS, Ross MF, Hagen TM, Murphy MP, Beckman JS.  2006.  Selective fluorescent imaging of superoxide in vivo using ethidium-based probes.. Proc Natl Acad Sci U S A. 103(41):15038-43.

Gómez LA, Hagen TM.  2012.  Age-related decline in mitochondrial bioenergetics: does supercomplex destabilization determine lower oxidative capacity and higher superoxide production? Semin Cell Dev Biol. 23(7):758-67.