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Found 467 results
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Hagen, Tory M
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Acetylcarnitine
Hagen TM
,
Liu J
,
Lykkesfeldt J
,
Wehr CM
,
Ingersoll RT
,
Vinarsky V
,
Bartholomew JC
,
Ames BN
. 2002.
Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.
.
Proc Natl Acad Sci U S A. 99(4):1870-5.
Gómez LA
,
Heath S-HD
,
Hagen TM
. 2012.
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.
.
Mech Ageing Dev. 133(2-3):99-106.
Hagen TM
,
Moreau R
,
Suh JH
,
Visioli F
. 2002.
Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.
.
Ann N Y Acad Sci. 959:491-507.
Acetylcysteine
Thomas NO
,
Shay KP
,
Kelley AR
,
Butler JA
,
Hagen TM
. 2016.
Glutathione maintenance mitigates age-related susceptibility to redox cycling agents.
.
Redox Biol. 10:45-52.
Acyltransferases
Moreau R
,
Heath S-HD
,
Doneanu CE
,
J Lindsay G
,
Hagen TM
. 2003.
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
.
Antioxid Redox Signal. 5(5):517-27.
Administration, Oral
Moreau R
,
Heath S-HD
,
Doneanu CE
,
J Lindsay G
,
Hagen TM
. 2003.
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
.
Antioxid Redox Signal. 5(5):517-27.
Adult
Keith DJ
,
Butler JA
,
Bemer B
,
Dixon B
,
Johnson S
,
Garrard M
,
Sudakin DL
,
J Christensen M
,
Pereira C
,
Hagen TM
. 2012.
Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study.
.
Pharmacol Res. 66(3):199-206.
Age Factors
Gómez LA
,
Heath S-HD
,
Hagen TM
. 2012.
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.
.
Mech Ageing Dev. 133(2-3):99-106.
Moreau R
,
Heath S-HD
,
Doneanu CE
,
J Lindsay G
,
Hagen TM
. 2003.
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
.
Antioxid Redox Signal. 5(5):517-27.
Keith DJ
,
Butler JA
,
Bemer B
,
Dixon B
,
Johnson S
,
Garrard M
,
Sudakin DL
,
J Christensen M
,
Pereira C
,
Hagen TM
. 2012.
Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study.
.
Pharmacol Res. 66(3):199-206.
Shay KPetersen
,
Hagen TM
. 2009.
Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.
.
Biogerontology. 10(4):443-56.
Hagen TM
,
Liu J
,
Lykkesfeldt J
,
Wehr CM
,
Ingersoll RT
,
Vinarsky V
,
Bartholomew JC
,
Ames BN
. 2002.
Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.
.
Proc Natl Acad Sci U S A. 99(4):1870-5.
Aged
Michels AJ
,
Butler JA
,
Uesugi SL
,
Lee K
,
Frei BB
,
Bobe G
,
Magnusson KR
,
Hagen TM
. 2023.
Multivitamin/Multimineral Supplementation Prevents or Reverses Decline in Vitamin Biomarkers and Cellular Energy Metabolism in Healthy Older Men: A Randomized, Double-Blind, Placebo-Controlled Study.
.
Nutrients. 15(12)
Keith DJ
,
Butler JA
,
Bemer B
,
Dixon B
,
Johnson S
,
Garrard M
,
Sudakin DL
,
J Christensen M
,
Pereira C
,
Hagen TM
. 2012.
Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study.
.
Pharmacol Res. 66(3):199-206.
Aging
Gómez LA
,
Hagen TM
. 2012.
Age-related decline in mitochondrial bioenergetics: does supercomplex destabilization determine lower oxidative capacity and higher superoxide production?
Semin Cell Dev Biol. 23(7):758-67.
Thomas NO
,
Shay KP
,
Kelley AR
,
Butler JA
,
Hagen TM
. 2016.
Glutathione maintenance mitigates age-related susceptibility to redox cycling agents.
.
Redox Biol. 10:45-52.
Moreau R
,
Heath S-HD
,
Doneanu CE
,
Harris RA
,
Hagen TM
. 2004.
Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart.
.
Biochem Biophys Res Commun. 325(1):48-58.
Hagen TM
,
Moreau R
,
Suh JH
,
Visioli F
. 2002.
Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.
.
Ann N Y Acad Sci. 959:491-507.
Suh JH
,
Shenvi SV
,
Dixon BM
,
Liu H
,
Jaiswal AK
,
Liu R-M
,
Hagen TM
. 2004.
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.
.
Proc Natl Acad Sci U S A. 101(10):3381-6.
Smith AR
,
Visioli F
,
Frei B
,
Hagen TM
. 2006.
Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.
.
Aging Cell. 5(5):391-400.
Smith AR
,
Visioli F
,
Hagen TM
. 2006.
Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age.
.
Arch Biochem Biophys. 454(1):100-5.
Moreau R
,
Heath S-HD
,
Doneanu CE
,
J Lindsay G
,
Hagen TM
. 2003.
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
.
Antioxid Redox Signal. 5(5):517-27.
Suh JH
,
Heath S-H
,
Hagen TM
. 2003.
Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress.
.
Free Radic Biol Med. 35(9):1064-72.
Michels AJ
,
Joisher N
,
Hagen TM
. 2003.
Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes.
.
Arch Biochem Biophys. 410(1):112-20.
Moreau R
,
Nguyen BT
,
Doneanu CE
,
Hagen TM
. 2005.
Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats.
.
Biochem Pharmacol. 69(1):29-40.
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