Found 443 results
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Aging
Smith AR, Visioli F, Frei B, Hagen TM.  2006.  Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.. Aging Cell. 5(5):391-400.
Smith AR, Visioli F, Hagen TM.  2006.  Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age.. Arch Biochem Biophys. 454(1):100-5.
Moreau R, Heath S-HD, Doneanu CE, J Lindsay G, Hagen TM.  2003.  Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.. Antioxid Redox Signal. 5(5):517-27.
Suh JH, Heath S-H, Hagen TM.  2003.  Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress.. Free Radic Biol Med. 35(9):1064-72.
Michels AJ, Joisher N, Hagen TM.  2003.  Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes.. Arch Biochem Biophys. 410(1):112-20.
Moreau R, Nguyen BT, Doneanu CE, Hagen TM.  2005.  Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats.. Biochem Pharmacol. 69(1):29-40.
Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SKate, Frei B, Hagen TM.  2012.  R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.. Am J Physiol Regul Integr Comp Physiol. 302(5):R587-97.
Li L, Smith A, Hagen TM, Frei B.  2010.  Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.. Ann N Y Acad Sci. 1203:151-9.
Shay KPetersen, Hagen TM.  2009.  Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.. Biogerontology. 10(4):443-56.
Suh JH, Moreau R, Heath S-HD, Hagen TM.  2005.  Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.. Redox Rep. 10(1):52-60.
Smith EJ, Shay KP, Thomas NO, Butler JA, Finlay LF, Hagen TM.  2015.  Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a.. Free Radic Biol Med. 89:1184-91.
Gómez LA, Hagen TM.  2012.  Age-related decline in mitochondrial bioenergetics: does supercomplex destabilization determine lower oxidative capacity and higher superoxide production? Semin Cell Dev Biol. 23(7):758-67.

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