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Faculty and Staff
Our Research
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Leonard, Scott W
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Maier MLVermilli
,
Siddens LK
,
Uesugi SL
,
Choi J
,
Leonard SW
,
Pennington JM
,
Tilton SC
,
Smith JN
,
Ho E
,
Chow HHSherry
et al.
. 2021.
3,3′-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans
.
Drug Metab Dispos.
5
Leonard SW
,
Bruno RS
,
Paterson E
,
Schock BC
,
Atkinson J
,
Bray TM
,
Cross CE
,
Traber MG
. 2003.
5-nitro-gamma-tocopherol increases in human plasma exposed to cigarette smoke in vitro and in vivo.
.
Free Radic Biol Med. 35(12):1560-7.
A
Matsumoto S
,
Traber MG
,
Leonard SW
,
Choi J
,
Fang X
,
Maishan M
,
Wick KD
,
Jones KD
,
Calfee CS
,
Gotts JE
et al.
. 2022.
Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages.
.
Am J Physiol Lung Cell Mol Physiol. 322(6):L771-L783.
Mustacich DJ
,
Leonard SW
,
Patel NK
,
Traber MG
. 2010.
Alpha-tocopherol beta-oxidation localized to rat liver mitochondria.
.
Free Radic Biol Med. 48(1):73-81.
Traber MG
,
Siddens LK
,
Leonard SW
,
Schock B
,
Gohil K
,
Krueger SK
,
Cross CE
,
Williams DE
. 2005.
Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.
.
Free Radic Biol Med. 38(6):773-85.
Mustacich DJ
,
Leonard SW
,
Devereaux MW
,
Sokol RJ
,
Traber MG
. 2006.
Alpha-tocopherol regulation of hepatic cytochrome P450s and ABC transporters in rats.
.
Free Radic Biol Med. 41(7):1069-78.
C
Henderson TD
,
Choi J
,
Leonard SW
,
Head B
,
Tanguay RL
,
Barton CL
,
Traber MG
. 2023.
Chronic Vitamin E Deficiency Dysregulates Purine, Phospholipid, and Amino Acid Metabolism in Aging Zebrafish Skeletal Muscle.
.
Antioxidants (Basel). 12(6)
Leonard SW
,
Bruno RS
,
Ramakrishnan R
,
Bray T
,
Traber MG
. 2004.
Cigarette smoking increases human vitamin E requirements as estimated by plasma deuterium-labeled CEHC.
.
Ann N Y Acad Sci. 1031:357-60.
D
Michels AJ
,
Leonard SW
,
Uesugi SL
,
Bobe G
,
Frei B
,
Traber MG
. 2018.
Daily Consumption of Oregon Hazelnuts Affects α-Tocopherol Status in Healthy Older Adults: A Pre-Post Intervention Study.
.
J Nutr. 148(12):1924-1930.
Farley SM
,
Leonard SW
,
Stevens JF
,
Traber MG
. 2014.
Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion.
.
Mol Nutr Food Res. 58(8):1610-9.
E
Fantacone ML
,
Lowry MB
,
Uesugi SL
,
Michels AJ
,
Choi J
,
Leonard SW
,
Gombart SK
,
Gombart JS
,
Bobe G
,
Gombart AF
. 2020.
The Effect of a Multivitamin and Mineral Supplement on Immune Function in Healthy Older Adults: A Double-Blind, Randomized, Controlled Trial.
.
Nutrients. 12(8)
F
Bruno RS
,
Leonard SW
,
Atkinson J
,
Montine TJ
,
Ramakrishnan R
,
Bray TM
,
Traber MG
. 2006.
Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation.
.
Free Radic Biol Med. 40(4):689-97.
G
Watt AT
,
Head B
,
Leonard SW
,
Tanguay RL
,
Traber MG
. 2021.
Gene Expression of CRAL_TRIO Family Proteins modulated by Vitamin E Deficiency in Zebrafish (Danio Rerio).
.
J Nutr Biochem. :108801.
Lim Y
,
Schock BC
,
Gohil K
,
Leonard SW
,
Packer L
,
Cross CE
,
Traber MG
. 2004.
Gene-nutrient interactions exemplified by the alpha-tocopherol content of tissues from alpha-tocopherol transfer protein-null mice fed different dietary vitamin E concentrations.
.
Ann N Y Acad Sci. 1031:328-9.
H
Tennant KG
,
Leonard SW
,
Wong CP
,
Iwaniec UT
,
Turner RT
,
Traber MG
. 2017.
High-Dietary Alpha-Tocopherol or Mixed Tocotrienols Have No Effect on Bone Mass, Density, or Turnover in Male Rats During Skeletal Maturation.
.
J Med Food. 20(7):700-708.
I
Leonard SW
,
Terasawa Y
,
Farese RV
,
Traber MG
. 2002.
Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice.
.
Am J Clin Nutr. 75(3):555-60.
Bobe G
,
Cobb TJ
,
Leonard SW
,
Aponso S
,
Bahro CB
,
Koley D
,
Mah E
,
Bruno RS
,
Traber MG
. 2017.
Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome.
.
Redox Biol. 12:121-128.
Lebold KM
,
Grant KA
,
Freeman WM
,
Wiren KM
,
Miller GW
,
Kiley C
,
Leonard SW
,
Traber MG
. 2011.
Individual differences in hyperlipidemia and vitamin E status in response to chronic alcohol self-administration in cynomolgus monkeys.
.
Alcohol Clin Exp Res. 35(3):474-83.
L
Bruno RS
,
Leonard SW
,
Li J
,
Bray TM
,
Traber MG
. 2005.
Lower plasma alpha-carboxyethyl-hydroxychroman after deuterium-labeled alpha-tocopherol supplementation suggests decreased vitamin E metabolism in smokers.
.
Am J Clin Nutr. 81(5):1052-9.
M
Leonard SW
,
Traber MG
. 2006.
Measurement of the vitamin E metabolites, carboxyethyl hydroxychromans (CEHCs), in biological samples.
.
Curr Protoc Toxicol. Chapter 7:Unit7.8.
Traber MG
,
Mah E
,
Leonard SW
,
Bobe G
,
Bruno RS
. 2017.
Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial.
.
Am J Clin Nutr. 105(3):571-579.
N
Chen L
,
Choi J
,
Leonard SW
,
Banuvar S
,
Barengolts E
,
Viana M
,
Chen S-N
,
Pauli GF
,
Bolton JL
,
van Breemen RB
. 2020.
No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women.
.
J Agric Food Chem. 68(47):13929-13939.
Choi J
,
Leonard SW
,
Kasper K
,
McDougall M
,
Stevens JF
,
Tanguay RL
,
Traber MG
. 2015.
Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics.
.
J Lipid Res. 56(6):1182-90.
Q
Leonard SW
,
Gumpricht E
,
Devereaux MW
,
Sokol RJ
,
Traber MG
. 2005.
Quantitation of rat liver vitamin E metabolites by LC-MS during high-dose vitamin E administration.
.
J Lipid Res. 46(5):1068-75.
R
Bella DL
,
Schock BC
,
Lim Y
,
Leonard SW
,
Berry C
,
Cross CE
,
Traber MG
. 2006.
Regulation of the alpha-tocopherol transfer protein in mice: lack of response to dietary vitamin E or oxidative stress.
.
Lipids. 41(2):105-12.
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