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Faculty and Staff
Our Research
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Biblio
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Siddens, Lisbeth K
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T
Madeen E
,
Siddens LK
,
Uesugi S
,
McQuistan T
,
Corley RA
,
Smith J
,
Waters KM
,
Tilton SC
,
Anderson KA
,
Ognibene T
et al.
. 2019.
Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing.
.
Toxicol Appl Pharmacol. 364:97-105.
P
Hummel JM
,
Madeen EP
,
Siddens LK
,
Uesugi SL
,
McQuistan T
,
Anderson KA
,
Turteltaub KW
,
Ognibene TJ
,
Bench G
,
Krueger SK
et al.
. 2018.
Pharmacokinetics of [C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction.
.
Food Chem Toxicol. 115:136-147.
M
Siddens LK
,
Krueger SK
,
Henderson MC
,
Williams DE
. 2014.
Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide.
.
Biochem Pharmacol. 89(1):141-7.
I
Maier MLVermilli
,
Siddens LK
,
Pennington JM
,
Uesugi SL
,
Labut EM
,
Vertel EA
,
Anderson KA
,
Tidwell LG
,
Tilton SC
,
Ognibene TJ
et al.
. 2023.
Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing.
.
Chem Biol Interact. 382:110608.
F
Henderson MC
,
Siddens LK
,
Krueger SK
,
J Stevens F
,
Kedzie K
,
Fang WK
,
Heidelbaugh T
,
Nguyen P
,
Chow K
,
Garst M
et al.
. 2014.
Flavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones.
.
Toxicol Appl Pharmacol. 278(2):91-9.
D
Madeen EP
,
Löhr CV
,
You H
,
Siddens LK
,
Krueger SK
,
Dashwood RH
,
Gonzalez FJ
,
Baird WM
,
Ho E
,
Bramer L
et al.
. 2017.
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.
.
Mol Carcinog. 56(1):163-171.
C
Siddens LK
,
Bunde KL
,
Harper TA
,
McQuistan TJ
,
Löhr CV
,
Bramer LM
,
Waters KM
,
Tilton SC
,
Krueger SK
,
Williams DE
et al.
. 2015.
Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse.
.
Toxicol Appl Pharmacol. 287(2):149-160.
Chang Y
,
Huynh CThanh Thu
,
Bastin KM
,
Rivera BN
,
Siddens LK
,
Tilton SC
. 2020.
Classifying polycyclic aromatic hydrocarbons by carcinogenic potency using in vitro biosignatures.
.
Toxicol In Vitro. 69:104991.
Krueger SK
,
Henderson MC
,
Siddens LK
,
VanDyke JE
,
Benninghoff AD
,
P Karplus A
,
Furnes B
,
Schlenk D
,
Williams DE
. 2009.
Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.
.
Drug Metab Dispos. 37(8):1785-91.
Siddens LK
,
Henderson MC
,
VanDyke JE
,
Williams DE
,
Krueger SK
. 2008.
Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms.
.
Biochem Pharmacol. 75(2):570-9.
B
Maier MLVermilli
,
Siddens LK
,
Pennington JM
,
Uesugi SL
,
Tilton SC
,
Vertel EA
,
Anderson KA
,
Tidwell LG
,
Ognibene TJ
,
Turteltaub KW
et al.
. 2023.
Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts.
.
Toxicol Appl Pharmacol. 460:116377.
Maier MLVermilli
,
Siddens LK
,
Pennington JM
,
Uesugi SL
,
Anderson KA
,
Tidwell LG
,
Tilton SC
,
Ognibene TJ
,
Turteltaub KW
,
Smith JN
et al.
. 2022.
Benzo[a]pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with [C]-BaP.
.
Environ Int. 159:107045.
A
Traber MG
,
Siddens LK
,
Leonard SW
,
Schock B
,
Gohil K
,
Krueger SK
,
Cross CE
,
Williams DE
. 2005.
Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.
.
Free Radic Biol Med. 38(6):773-85.
3
Maier MLVermilli
,
Siddens LK
,
Uesugi SL
,
Choi J
,
Leonard SW
,
Pennington JM
,
Tilton SC
,
Smith JN
,
Ho E
,
Chow HHSherry
et al.
. 2021.
3,3′-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans
.
Drug Metab Dispos.
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