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Faculty and Staff
Our Research
Micronutrient Information
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Stevens, Jan F
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Plasma
Sowell J
,
Frei B
,
Stevens JF
. 2004.
Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma.
.
Proc Natl Acad Sci U S A. 101(52):17964-9.
Platelet Aggregation Inhibitors
Zheng TJ
,
Kohs TCL
,
Mueller PA
,
Pang J
,
Reitsma SE
,
Parra-Izquierdo I
,
Melrose AR
,
Yang L
,
Choi J
,
Zientek KD
et al.
. 2023.
Effect of antiplatelet agents and tyrosine kinase inhibitors on oxLDL-mediated procoagulant platelet activity.
.
Blood Adv. 7(8):1366-1378.
Polycyclic Aromatic Hydrocarbons
Elie MR
,
Choi J
,
Nkrumah-Elie YM
,
Gonnerman GD
,
Stevens JF
,
Tanguay RL
. 2015.
Metabolomic analysis to define and compare the effects of PAHs and oxygenated PAHs in developing zebrafish.
.
Environ Res. 140:502-10.
Polyphenols
Kesinger NG
,
Stevens JF
. 2009.
Covalent interaction of ascorbic acid with natural products.
.
Phytochemistry. 70(17-18):1930-9.
Prebiotics
Jamieson PE
,
Smart EB
,
Bouranis JA
,
Choi J
,
Danczak RE
,
Wong CP
,
Paraiso IL
,
Maier CS
,
Ho E
,
Sharpton TJ
et al.
. 2024.
Gut enterotype-dependent modulation of gut microbiota and their metabolism in response to xanthohumol supplementation in healthy adults.
.
Gut Microbes. 16(1):2315633.
Propiophenones
Yang L
,
Broderick D
,
Campbell Y
,
Gombart AF
,
Stevens JF
,
Jiang Y
,
Hsu VL
,
Bisson WH
,
Maier CS
. 2016.
Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies.
.
Biochim Biophys Acta. 1864(12):1667-1677.
Kirkwood JS
,
Maier C
,
Stevens JF
. 2013.
Simultaneous, untargeted metabolic profiling of polar and nonpolar metabolites by LC-Q-TOF mass spectrometry.
.
Curr Protoc Toxicol. Chapter 4:Unit4.39.
Stevens JF
,
Page JE
. 2004.
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
.
Phytochemistry. 65(10):1317-30.
Miranda CL
,
Elias VD
,
Hay JJ
,
Choi J
,
Reed RL
,
Stevens JF
. 2016.
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
.
Arch Biochem Biophys. 599:22-30.
Logan IE
,
Shulzhenko N
,
Sharpton TJ
,
Bobe G
,
Liu K
,
Nuss S
,
Jones ML
,
Miranda CL
,
Vasquez-Perez S
,
Pennington JM
et al.
. 2021.
Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice.
.
Mol Nutr Food Res. 65(21):e2100389.
Ellinwood DC
,
El-Mansy MF
,
Plagmann LS
,
Stevens JF
,
Maier CS
,
Gombart AF
,
Blakemore PR
. 2017.
Total synthesis of [ C] -, [ C] -, and [ C] -isotopomers of xanthohumol, the principal prenylflavonoid from hops.
.
J Labelled Comp Radiopharm. 60(14):639-648.
Legette LCL
,
Luna AYMoreno
,
Reed RL
,
Miranda CL
,
Bobe G
,
Proteau RR
,
Stevens JF
. 2013.
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
.
Phytochemistry. 91:236-41.
Kirkwood JS
,
Legette LCL
,
Miranda CL
,
Jiang Y
,
Stevens JF
. 2013.
A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.
.
J Biol Chem. 288(26):19000-13.
Legette LC
,
Karnpracha C
,
Reed RL
,
Choi J
,
Bobe G
,
J Christensen M
,
Rodriguez-Proteau R
,
Purnell JQ
,
Stevens JF
. 2014.
Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops.
.
Mol Nutr Food Res. 58(2):248-55.
Legette LC
,
Ma L
,
Reed RL
,
Miranda CL
,
Christensen JMark
,
Rodriguez-Proteau R
,
Stevens JF
. 2012.
Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.
.
Mol Nutr Food Res. 56(3):466-74.
Lela L
,
Ponticelli M
,
Carlucci V
,
Stevens JF
,
Faraone I
,
Tzvetkov NT
,
Milella L
. 2024.
Insight into the Interaction of L. Specialized Metabolites and Gastrointestinal Bitter Taste Receptors: Study in STC-1 Cells and Molecular Docking.
.
J Nat Prod. 87(8):2021-2033.
Jamieson PE
,
Smart EB
,
Bouranis JA
,
Choi J
,
Danczak RE
,
Wong CP
,
Paraiso IL
,
Maier CS
,
Ho E
,
Sharpton TJ
et al.
. 2024.
Gut enterotype-dependent modulation of gut microbiota and their metabolism in response to xanthohumol supplementation in healthy adults.
.
Gut Microbes. 16(1):2315633.
Proprotein Convertase 9
Miranda CL
,
Elias VD
,
Hay JJ
,
Choi J
,
Reed RL
,
Stevens JF
. 2016.
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
.
Arch Biochem Biophys. 599:22-30.
Protein Carbonylation
Miranda CL
,
Reed RL
,
Kuiper HC
,
Alber S
,
Stevens JF
. 2009.
Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells.
.
Chem Res Toxicol. 22(5):863-74.
Protein Conformation
Yang L
,
Broderick D
,
Campbell Y
,
Gombart AF
,
Stevens JF
,
Jiang Y
,
Hsu VL
,
Bisson WH
,
Maier CS
. 2016.
Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies.
.
Biochim Biophys Acta. 1864(12):1667-1677.
Sowell J
,
Frei B
,
Stevens JF
. 2004.
Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma.
.
Proc Natl Acad Sci U S A. 101(52):17964-9.
Protein Hydrolysates
Wattanasiritham L
,
Theerakulkait C
,
Wickramasekara S
,
Maier CS
,
Stevens JF
. 2016.
Isolation and identification of antioxidant peptides from enzymatically hydrolyzed rice bran protein.
.
Food Chem. 192:156-62.
Protein Structure, Tertiary
Sowell J
,
Frei B
,
Stevens JF
. 2004.
Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma.
.
Proc Natl Acad Sci U S A. 101(52):17964-9.
Purine Nucleotides
Kirkwood JS
,
Lebold KM
,
Miranda CL
,
Wright CL
,
Miller GW
,
Tanguay RL
,
Barton CL
,
Traber MG
,
Stevens JF
. 2012.
Vitamin C deficiency activates the purine nucleotide cycle in zebrafish.
.
J Biol Chem. 287(6):3833-41.
Quinic Acid
Gray NE
,
Morré J
,
Kelley J
,
Maier CS
,
Stevens JF
,
Quinn JF
,
Soumyanath A
. 2014.
Caffeoylquinic acids in Centella asiatica protect against amyloid-β toxicity.
.
J Alzheimers Dis. 40(2):359-73.
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