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Faculty and Staff
Our Research
Micronutrient Information
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Stevens, Jan F
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Blood Glucose
Legette LCL
,
Luna AYMoreno
,
Reed RL
,
Miranda CL
,
Bobe G
,
Proteau RR
,
Stevens JF
. 2013.
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
.
Phytochemistry. 91:236-41.
Miranda CL
,
Elias VD
,
Hay JJ
,
Choi J
,
Reed RL
,
Stevens JF
. 2016.
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
.
Arch Biochem Biophys. 599:22-30.
Body Weight
Johnson LA
,
Torres ERuth S
,
Impey S
,
Stevens JF
,
Raber J
. 2017.
Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome.
.
Sci Rep. 7:43701.
Brain
Choi J
,
Leonard SW
,
Kasper K
,
McDougall M
,
Stevens JF
,
Tanguay RL
,
Traber MG
. 2015.
Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics.
.
J Lipid Res. 56(6):1182-90.
Farley SM
,
Leonard SW
,
Stevens JF
,
Traber MG
. 2014.
Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion.
.
Mol Nutr Food Res. 58(8):1610-9.
Khorani M
,
Bobe G
,
Matthews DG
,
Magana AAlcazar
,
Caruso M
,
Gray NE
,
Quinn JF
,
Stevens JF
,
Soumyanath A
,
Maier CS
. 2022.
The Impact of the hAPP695SW Transgene and Associated Amyloid-β Accumulation on Murine Hippocampal Biochemical Pathways.
.
J Alzheimers Dis. 85(4):1601-1619.
Choi J
,
Yin T
,
Shinozaki K
,
Lampe JW
,
Stevens JF
,
Becker LB
,
Kim J
. 2018.
Comprehensive analysis of phospholipids in the brain, heart, kidney, and liver: brain phospholipids are least enriched with polyunsaturated fatty acids.
.
Mol Cell Biochem. 442(1-2):187-201.
Brassica
Bouranis JA
,
Beaver LM
,
Choi J
,
Wong CP
,
Jiang D
,
Sharpton TJ
,
Stevens JF
,
Ho E
. 2021.
Composition of the Gut Microbiome Influences Production of Sulforaphane-Nitrile and Iberin-Nitrile from Glucosinolates in Broccoli Sprouts.
.
Nutrients. 13(9)
Bouranis JA
,
Beaver LM
,
Jiang D
,
Choi J
,
Wong CP
,
Davis EW
,
Williams DE
,
Sharpton TJ
,
Stevens JF
,
Ho E
. 2022.
Interplay between Cruciferous Vegetables and the Gut Microbiome: A Multi-Omic Approach.
.
Nutrients. 15(1)
Bouranis JA
,
Beaver LM
,
Wong CP
,
Choi J
,
Hamer S
,
Davis EW
,
Brown KS
,
Jiang D
,
Sharpton TJ
,
Stevens JF
et al.
. 2024.
Sulforaphane and Sulforaphane-Nitrile Metabolism in Humans Following Broccoli Sprout Consumption: Inter-individual Variation, Association with Gut Microbiome Composition, and Differential Bioactivity.
.
Mol Nutr Food Res. 68(4):e2300286.
Buprenorphine
DenHerder JM
,
Reed RL
,
Sargent JL
,
Bobe G
,
Stevens JF
,
Diggs HE
. 2017.
Effects of Time and Storage Conditions on the Chemical and Microbiologic Stability of Diluted Buprenorphine for Injection.
.
J Am Assoc Lab Anim Sci. 56(4):457-461.
Calibration
Sowell J
,
Frei B
,
Stevens JF
. 2004.
Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma.
.
Proc Natl Acad Sci U S A. 101(52):17964-9.
Kuiper HC
,
Stevens JF
. 2011.
LC-MS/MS quantitation of mercapturic acid conjugates of lipid peroxidation products as markers of oxidative stress.
.
Curr Protoc Toxicol. Chapter 17:Unit17.14.2.
Carbohydrate Metabolism
Miranda CL
,
Elias VD
,
Hay JJ
,
Choi J
,
Reed RL
,
Stevens JF
. 2016.
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
.
Arch Biochem Biophys. 599:22-30.
Carbon Isotopes
Ellinwood DC
,
El-Mansy MF
,
Plagmann LS
,
Stevens JF
,
Maier CS
,
Gombart AF
,
Blakemore PR
. 2017.
Total synthesis of [ C] -, [ C] -, and [ C] -isotopomers of xanthohumol, the principal prenylflavonoid from hops.
.
J Labelled Comp Radiopharm. 60(14):639-648.
Han B
,
Stevens JF
,
Maier CS
. 2007.
Design, synthesis, and application of a hydrazide-functionalized isotope-coded affinity tag for the quantification of oxylipid-protein conjugates.
.
Anal Chem. 79(9):3342-54.
Carbon Tetrachloride
Kuiper HC
,
Miranda CL
,
Sowell JD
,
Stevens JF
. 2008.
Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress.
.
J Biol Chem. 283(25):17131-8.
Caspase 3
Miranda CL
,
Reed RL
,
Kuiper HC
,
Alber S
,
Stevens JF
. 2009.
Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells.
.
Chem Res Toxicol. 22(5):863-74.
Cell Death
Gray NE
,
Morré J
,
Kelley J
,
Maier CS
,
Stevens JF
,
Quinn JF
,
Soumyanath A
. 2014.
Caffeoylquinic acids in Centella asiatica protect against amyloid-β toxicity.
.
J Alzheimers Dis. 40(2):359-73.
Cell Differentiation
Kirkwood JS
,
Miranda CL
,
Bobe G
,
Maier CS
,
Stevens JF
. 2016.
18O-Tracer Metabolomics Reveals Protein Turnover and CDP-Choline Cycle Activity in Differentiating 3T3-L1 Pre-Adipocytes.
.
PLoS One. 11(6):e0157118.
Cell Line
Kirkwood JS
,
Legette LCL
,
Miranda CL
,
Jiang Y
,
Stevens JF
. 2013.
A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.
.
J Biol Chem. 288(26):19000-13.
Lela L
,
Ponticelli M
,
Carlucci V
,
Stevens JF
,
Faraone I
,
Tzvetkov NT
,
Milella L
. 2024.
Insight into the Interaction of L. Specialized Metabolites and Gastrointestinal Bitter Taste Receptors: Study in STC-1 Cells and Molecular Docking.
.
J Nat Prod. 87(8):2021-2033.
Axton ER
,
Hardardt EA
,
Stevens JF
. 2016.
Stable isotope-assisted LC-MS/MS monitoring of glyceryl trinitrate bioactivation in a cell culture model of nitrate tolerance.
.
J Chromatogr B Analyt Technol Biomed Life Sci. 1019:156-63.
Kesinger NG
,
Langsdorf BL
,
Yokochi AF
,
Miranda CL
,
Stevens JF
. 2010.
Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal.
.
Chem Res Toxicol. 23(4):836-44.
Cell Line, Transformed
Gray NE
,
Morré J
,
Kelley J
,
Maier CS
,
Stevens JF
,
Quinn JF
,
Soumyanath A
. 2014.
Caffeoylquinic acids in Centella asiatica protect against amyloid-β toxicity.
.
J Alzheimers Dis. 40(2):359-73.
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