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Williams, David E
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Carcinogens
Wang R
,
Chen Y-S
,
Dashwood W-M
,
Li Q
,
Löhr CV
,
Fischer K
,
Ho E
,
Williams DE
,
Dashwood RH
. 2017.
Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors.
.
Mol Carcinog. 56(7):1733-1742.
Bailey GS
,
Reddy AP
,
Pereira CB
,
Harttig U
,
Baird W
,
Spitsbergen JM
,
Hendricks JD
,
Orner GA
,
Williams DE
,
Swenberg JA
. 2009.
Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study.
.
Chem Res Toxicol. 22(7):1264-76.
Tilton SC
,
Givan SA
,
Pereira CB
,
Bailey GS
,
Williams DE
. 2006.
Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout.
.
Toxicol Sci. 90(1):61-72.
Simonich MT
,
Egner PA
,
Roebuck BD
,
Orner GA
,
Jubert C
,
Pereira C
,
Groopman JD
,
Kensler TW
,
Dashwood RH
,
Williams DE
et al.
. 2007.
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat.
.
Carcinogenesis. 28(6):1294-302.
Parasramka MA
,
W Dashwood M
,
Wang R
,
Abdelli A
,
Bailey GS
,
Williams DE
,
Ho E
,
Dashwood RH
. 2012.
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.
.
Mol Nutr Food Res. 56(8):1259-69.
Wang R
,
W Dashwood M
,
Bailey GS
,
Williams DE
,
Dashwood RH
. 2006.
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.
.
Mutat Res. 601(1-2):11-8.
Wang R
,
W Dashwood M
,
Löhr CV
,
Fischer KA
,
Nakagama H
,
Williams DE
,
Dashwood RH
. 2008.
beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet.
.
Cancer Sci. 99(9):1754-9.
Wang R
,
W Dashwood M
,
Löhr CV
,
Fischer KA
,
Pereira CB
,
Louderback M
,
Nakagama H
,
Bailey GS
,
Williams DE
,
Dashwood RH
. 2008.
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.
.
Carcinogenesis. 29(4):834-9.
Hummel JM
,
Madeen EP
,
Siddens LK
,
Uesugi SL
,
McQuistan T
,
Anderson KA
,
Turteltaub KW
,
Ognibene TJ
,
Bench G
,
Krueger SK
et al.
. 2018.
Pharmacokinetics of [C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction.
.
Food Chem Toxicol. 115:136-147.
Siddens LK
,
Bunde KL
,
Harper TA
,
McQuistan TJ
,
Löhr CV
,
Bramer LM
,
Waters KM
,
Tilton SC
,
Krueger SK
,
Williams DE
et al.
. 2015.
Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse.
.
Toxicol Appl Pharmacol. 287(2):149-160.
Madeen EP
,
Löhr CV
,
You H
,
Siddens LK
,
Krueger SK
,
Dashwood RH
,
Gonzalez FJ
,
Baird WM
,
Ho E
,
Bramer L
et al.
. 2017.
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.
.
Mol Carcinog. 56(1):163-171.
Carcinoma, Squamous Cell
Wang R
,
Chen Y-S
,
Dashwood W-M
,
Li Q
,
Löhr CV
,
Fischer K
,
Ho E
,
Williams DE
,
Dashwood RH
. 2017.
Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors.
.
Mol Carcinog. 56(7):1733-1742.
Carrier Proteins
Rajendran P
,
Kidane AI
,
Yu T-W
,
Dashwood W-M
,
Bisson WH
,
Löhr CV
,
Ho E
,
Williams DE
,
Dashwood RH
. 2013.
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.
.
Epigenetics. 8(6):612-23.
Traber MG
,
Siddens LK
,
Leonard SW
,
Schock B
,
Gohil K
,
Krueger SK
,
Cross CE
,
Williams DE
. 2005.
Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.
.
Free Radic Biol Med. 38(6):773-85.
Caspases
Leibelt DA
,
Hedstrom OR
,
Fischer KA
,
Pereira CB
,
Williams DE
. 2003.
Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3'-diindolylmethane in sprague-dawley rats.
.
Toxicol Sci. 74(1):10-21.
Catechin
Wang R
,
W Dashwood M
,
Löhr CV
,
Fischer KA
,
Pereira CB
,
Louderback M
,
Nakagama H
,
Bailey GS
,
Williams DE
,
Dashwood RH
. 2008.
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.
.
Carcinogenesis. 29(4):834-9.
Catenins
Wang R
,
Chen Y-S
,
Dashwood W-M
,
Li Q
,
Löhr CV
,
Fischer K
,
Ho E
,
Williams DE
,
Dashwood RH
. 2017.
Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors.
.
Mol Carcinog. 56(7):1733-1742.
Cell Cycle Checkpoints
Rajendran P
,
Kidane AI
,
Yu T-W
,
Dashwood W-M
,
Bisson WH
,
Löhr CV
,
Ho E
,
Williams DE
,
Dashwood RH
. 2013.
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.
.
Epigenetics. 8(6):612-23.
Cell Death
Leibelt DA
,
Hedstrom OR
,
Fischer KA
,
Pereira CB
,
Williams DE
. 2003.
Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3'-diindolylmethane in sprague-dawley rats.
.
Toxicol Sci. 74(1):10-21.
Watson GW
,
Wickramasekara S
,
Fang Y
,
Palomera-Sanchez Z
,
Maier CS
,
Williams DE
,
Dashwood RH
,
Perez VI
,
Ho E
. 2015.
Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells.
.
Mol Nutr Food Res. 59(10):1954-61.
Cell Line
Henderson MC
,
Siddens LK
,
Krueger SK
,
J Stevens F
,
Kedzie K
,
Fang WK
,
Heidelbaugh T
,
Nguyen P
,
Chow K
,
Garst M
et al.
. 2014.
Flavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones.
.
Toxicol Appl Pharmacol. 278(2):91-9.
Krueger SK
,
Martin SR
,
Yueh M-F
,
Pereira CB
,
Williams DE
. 2002.
Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein.
.
Drug Metab Dispos. 30(1):34-41.
Rajendran P
,
Kidane AI
,
Yu T-W
,
Dashwood W-M
,
Bisson WH
,
Löhr CV
,
Ho E
,
Williams DE
,
Dashwood RH
. 2013.
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.
.
Epigenetics. 8(6):612-23.
Cell Line, Tumor
Chimploy K
,
G Díaz D
,
Li Q
,
Carter O
,
Dashwood W-M
,
Mathews CK
,
Williams DE
,
Bailey GS
,
Dashwood RH
. 2009.
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.
.
Int J Cancer. 125(9):2086-94.
Rajendran P
,
Kidane AI
,
Yu T-W
,
Dashwood W-M
,
Bisson WH
,
Löhr CV
,
Ho E
,
Williams DE
,
Dashwood RH
. 2013.
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.
.
Epigenetics. 8(6):612-23.
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