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Faculty and Staff
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Biblio
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Williams, David E
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Beaver LM
,
Yu T-W
,
Sokolowski EI
,
Williams DE
,
Dashwood RH
,
Ho E
. 2012.
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells.
.
Toxicol Appl Pharmacol. 263(3):345-51.
Maier MLVermilli
,
Siddens LK
,
Uesugi SL
,
Choi J
,
Leonard SW
,
Pennington JM
,
Tilton SC
,
Smith JN
,
Ho E
,
Chow HHSherry
et al.
. 2021.
3,3′-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans
.
Drug Metab Dispos.
A
Traber MG
,
Siddens LK
,
Leonard SW
,
Schock B
,
Gohil K
,
Krueger SK
,
Cross CE
,
Williams DE
. 2005.
Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.
.
Free Radic Biol Med. 38(6):773-85.
Watson GW
,
Wickramasekara S
,
Fang Y
,
Palomera-Sanchez Z
,
Maier CS
,
Williams DE
,
Dashwood RH
,
Perez VI
,
Ho E
. 2015.
Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells.
.
Mol Nutr Food Res. 59(10):1954-61.
Harper TA
,
Morré J
,
Lauer FT
,
McQuistan TJ
,
Hummel JM
,
Burchiel SW
,
Williams DE
. 2015.
Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS.
.
Mutat Res Genet Toxicol Environ Mutagen. 782:51-6.
Watson GW
,
Wickramasekara S
,
Maier CS
,
Williams DE
,
Dashwood RH
,
Ho E
. 2015.
Assessment of global proteome in LNCaP cells by 2D-RP/RP LC-MS/MS following sulforaphane exposure.
.
EuPA Open Proteom. 9:34-40.
Williams DE
. 2018.
Association Is Not Causation.
.
Toxicol Sci. 164(1):3.
B
Maier MLVermilli
,
Siddens LK
,
Pennington JM
,
Uesugi SL
,
Anderson KA
,
Tidwell LG
,
Tilton SC
,
Ognibene TJ
,
Turteltaub KW
,
Smith JN
et al.
. 2022.
Benzo[a]pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with [C]-BaP.
.
Environ Int. 159:107045.
Maier MLVermilli
,
Siddens LK
,
Pennington JM
,
Uesugi SL
,
Tilton SC
,
Vertel EA
,
Anderson KA
,
Tidwell LG
,
Ognibene TJ
,
Turteltaub KW
et al.
. 2023.
Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts.
.
Toxicol Appl Pharmacol. 460:116377.
Wang R
,
W Dashwood M
,
Löhr CV
,
Fischer KA
,
Nakagama H
,
Williams DE
,
Dashwood RH
. 2008.
beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet.
.
Cancer Sci. 99(9):1754-9.
Beaver LM
,
Lӧhr CV
,
Clarke JD
,
Glasser ST
,
Watson GW
,
Wong CP
,
Zhang Z
,
Williams DE
,
Dashwood RH
,
Shannon J
et al.
. 2018.
Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.
.
Curr Dev Nutr. 2(3):nzy002.
C
McQuistan TJ
,
Simonich MT
,
M Pratt M
,
Pereira CB
,
Hendricks JD
,
Dashwood RH
,
Williams DE
,
Bailey GS
. 2012.
Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study.
.
Food Chem Toxicol. 50(2):341-52.
Siddens LK
,
Henderson MC
,
VanDyke JE
,
Williams DE
,
Krueger SK
. 2008.
Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms.
.
Biochem Pharmacol. 75(2):570-9.
Krueger SK
,
Henderson MC
,
Siddens LK
,
VanDyke JE
,
Benninghoff AD
,
P Karplus A
,
Furnes B
,
Schlenk D
,
Williams DE
. 2009.
Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.
.
Drug Metab Dispos. 37(8):1785-91.
Higdon JV
,
Delage B
,
Williams DE
,
Dashwood RH
. 2007.
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.
.
Pharmacol Res. 55(3):224-36.
Siddens LK
,
Bunde KL
,
Harper TA
,
McQuistan TJ
,
Löhr CV
,
Bramer LM
,
Waters KM
,
Tilton SC
,
Krueger SK
,
Williams DE
et al.
. 2015.
Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse.
.
Toxicol Appl Pharmacol. 287(2):149-160.
D
Larkin A
,
Williams DE
,
Kile ML
,
Baird WM
. 2015.
Developing a smartphone software package for predicting atmospheric pollutant concentrations at mobile locations.
.
Comput J. 58(6):1431-1442.
Larsen-Su SA
,
Krueger SK
,
Yueh MFei
,
Pereira CB
,
Williams DE
. 2002.
Developmental regulation of flavin-containing monooxygenase form 1 in the liver and kidney of fetal and neonatal rabbits.
.
Biochem Pharmacol. 63(7):1353-9.
Madeen EP
,
Löhr CV
,
You H
,
Siddens LK
,
Krueger SK
,
Dashwood RH
,
Gonzalez FJ
,
Baird WM
,
Ho E
,
Bramer L
et al.
. 2017.
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.
.
Mol Carcinog. 56(1):163-171.
Ho E
,
Beaver LM
,
Williams DE
,
Dashwood RH
. 2011.
Dietary factors and epigenetic regulation for prostate cancer prevention.
.
Adv Nutr. 2(6):497-510.
Rajendran P
,
Ho E
,
Williams DE
,
Dashwood RH
. 2011.
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.
.
Clin Epigenetics. 3(1):4.
Wang R
,
Chen Y-S
,
Dashwood W-M
,
Li Q
,
Löhr CV
,
Fischer K
,
Ho E
,
Williams DE
,
Dashwood RH
. 2017.
Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors.
.
Mol Carcinog. 56(7):1733-1742.
E
Chimploy K
,
G Díaz D
,
Li Q
,
Carter O
,
Dashwood W-M
,
Mathews CK
,
Williams DE
,
Bailey GS
,
Dashwood RH
. 2009.
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.
.
Int J Cancer. 125(9):2086-94.
Wong CP
,
Hsu A
,
Buchanan A
,
Palomera-Sanchez Z
,
Beaver LM
,
E Houseman A
,
Williams DE
,
Dashwood RH
,
Ho E
. 2014.
Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.
.
PLoS One. 9(1):e86787.
Wang R
,
Löhr CV
,
Fischer K
,
W Dashwood M
,
Greenwood JA
,
Ho E
,
Williams DE
,
Ashktorab H
,
Dashwood MR
,
Dashwood RH
. 2013.
Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.
.
Int J Cancer. 132(5):1004-12.
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