Found 665 results
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Reactive Oxygen Species
Li L, Frei B.  2006.  Iron chelation inhibits NF-kappaB-mediated adhesion molecule expression by inhibiting p22(phox) protein expression and NADPH oxidase activity.. Arterioscler Thromb Vasc Biol. 26(12):2638-43.
Rats, Inbred F344
Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SKate, Frei B, Hagen TM.  2012.  R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.. Am J Physiol Regul Integr Comp Physiol. 302(5):R587-97.
Li L, Smith A, Hagen TM, Frei B.  2010.  Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.. Ann N Y Acad Sci. 1203:151-9.
Smith AR, Visioli F, Frei B, Hagen TM.  2006.  Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.. Aging Cell. 5(5):391-400.
Rats, Inbred BN
Smith AR, Visioli F, Frei B, Hagen TM.  2006.  Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.. Aging Cell. 5(5):391-400.
Rats
Smith AR, Visioli F, Frei B, Hagen TM.  2006.  Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.. Aging Cell. 5(5):391-400.
Li L, Smith A, Hagen TM, Frei B.  2010.  Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.. Ann N Y Acad Sci. 1203:151-9.
Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SKate, Frei B, Hagen TM.  2012.  R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.. Am J Physiol Regul Integr Comp Physiol. 302(5):R587-97.
Randomized Controlled Trials as Topic
Frei B, Birlouez-Aragon I, Lykkesfeldt J.  2012.  Authors' perspective: What is the optimum intake of vitamin C in humans? Crit Rev Food Sci Nutr. 52(9):815-29.
Michels AJ, Frei B.  2013.  Myths, artifacts, and fatal flaws: identifying limitations and opportunities in vitamin C research.. Nutrients. 5(12):5161-92.
Random Allocation
Mastaloudis A, Yu T-W, O'Donnell RP, Frei B, Dashwood RH, Traber MG.  2004.  Endurance exercise results in DNA damage as detected by the comet assay.. Free Radic Biol Med. 36(8):966-75.
Quercetin
Li C, Zhang W-J, Choi J, Frei B.  2016.  Quercetin affects glutathione levels and redox ratio in human aortic endothelial cells not through oxidation but formation and cellular export of quercetin-glutathione conjugates and upregulation of glutamate-cysteine ligase.. Redox Biol. 9:220-228.
Li C, Zhang W-J, Frei B.  2016.  Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction.. Redox Biol. 9:104-113.
Pyrrolidonecarboxylic Acid
Visioli F, Smith A, Zhang W, Keaney JF, Hagen T, Frei B.  2002.  Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status.. Redox Rep. 7(4):223-7.
Pyrrolidines
Zhu B-Z, Carr AC, Frei B.  2002.  Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damage.. FEBS Lett. 532(1-2):80-4.
Proto-Oncogene Proteins c-akt
Zhang W-J, Wei H, Hagen T, Frei B.  2007.  Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway.. Proc Natl Acad Sci U S A. 104(10):4077-82.
Protein Structure, Tertiary
Sowell J, Frei B, Stevens JF.  2004.  Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma.. Proc Natl Acad Sci U S A. 101(52):17964-9.
Protein Phosphatase 2
Smith AR, Visioli F, Frei B, Hagen TM.  2006.  Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.. Aging Cell. 5(5):391-400.
Protein Conformation
Sowell J, Frei B, Stevens JF.  2004.  Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma.. Proc Natl Acad Sci U S A. 101(52):17964-9.
Prodrugs
Frei B, Lawson S.  2008.  Vitamin C and cancer revisited.. Proc Natl Acad Sci U S A. 105(32):11037-8.
Primary Prevention
Traber MG, Frei B, Beckman JS.  2008.  Vitamin E revisited: do new data validate benefits for chronic disease prevention? Curr Opin Lipidol. 19(1):30-8.
Prevalence
Blumberg JB, Frei B, Fulgoni VL, Weaver CM, Zeisel SH.  2017.  Contribution of Dietary Supplements to Nutritional Adequacy by Socioeconomic Subgroups in Adults of the United States.. Nutrients. 10(1)
Pregnancy
Higdon JV, Frei B.  2006.  Coffee and health: a review of recent human research.. Crit Rev Food Sci Nutr. 46(2):101-23.
Poverty
Blumberg JB, Frei B, Fulgoni VL, Weaver CM, Zeisel SH.  2017.  Contribution of Dietary Supplements to Nutritional Adequacy by Socioeconomic Subgroups in Adults of the United States.. Nutrients. 10(1)
Polyphenols
Lotito SB, Frei B.  2004.  Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects.. Free Radic Biol Med. 36(2):201-11.

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