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About the LPI
Faculty and Staff
Our Research
Micronutrient Information
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Biblio
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Linoleic Acid
Jump DB
,
Torres-Gonzalez M
,
L Olson K
. 2011.
Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation.
.
Biochem Pharmacol. 81(5):649-60.
Lebold KM
,
Jump DB
,
Miller GW
,
Wright CL
,
Labut EM
,
Barton CL
,
Tanguay RL
,
Traber MG
. 2011.
Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio).
.
J Nutr. 141(12):2113-8.
Isoenzymes
Tripathy S
,
Torres-Gonzalez M
,
Jump DB
. 2010.
Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice.
.
J Lipid Res. 51(9):2642-54.
Interleukin 1 Receptor Antagonist Protein
Lytle KA
,
Wong CP
,
Jump DB
. 2017.
Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-/- mice.
.
PLoS One. 12(4):e0173376.
Insulin
Tripathy S
,
Torres-Gonzalez M
,
Jump DB
. 2010.
Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice.
.
J Lipid Res. 51(9):2642-54.
Inflammation
Depner CM
,
Torres-Gonzalez M
,
Tripathy S
,
Milne G
,
Jump DB
. 2012.
Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/- mice.
.
J Nutr. 142(8):1495-503.
Lytle KA
,
Jump DB
. 2016.
Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?
PLoS One. 11(1):e0146942.
Hyperglycemia
Tripathy S
,
Torres-Gonzalez M
,
Jump DB
. 2010.
Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice.
.
J Lipid Res. 51(9):2642-54.
Humans
Jump DB
,
Torres-Gonzalez M
,
L Olson K
. 2011.
Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation.
.
Biochem Pharmacol. 81(5):649-60.
Tripathy S
,
Torres-Gonzalez M
,
Jump DB
. 2010.
Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice.
.
J Lipid Res. 51(9):2642-54.
Jump DB
. 2008.
N-3 polyunsaturated fatty acid regulation of hepatic gene transcription.
.
Curr Opin Lipidol. 19(3):242-7.
Tripathy S
,
Lytle KA
,
Stevens RD
,
Bain JR
,
Newgard CB
,
Greenberg AS
,
Huang L-S
,
Jump DB
. 2014.
Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice.
.
J Lipid Res. 55(7):1448-64.
Jump DB
,
Tripathy S
,
Depner CM
. 2013.
Fatty acid-regulated transcription factors in the liver.
.
Annu Rev Nutr. 33:249-69.
Jump DB
,
Depner CM
,
Tripathy S
. 2012.
Omega-3 fatty acid supplementation and cardiovascular disease.
.
J Lipid Res. 53(12):2525-45.
Jump DB
,
Depner CM
,
Tripathy S
,
Lytle KA
. 2015.
Potential for dietary ω-3 fatty acids to prevent nonalcoholic fatty liver disease and reduce the risk of primary liver cancer.
.
Adv Nutr. 6(6):694-702.
Padiadpu J
,
Garcia-Jaramillo M
,
Newman NK
,
Pederson JW
,
Rodrigues R
,
Li Z
,
Singh S
,
Monnier P
,
Trinchieri G
,
Brown K
et al.
. 2023.
Multi-omic network analysis identified betacellulin as a novel target of omega-3 fatty acid attenuation of western diet-induced nonalcoholic steatohepatitis.
.
EMBO Mol Med. 15(11):e18367.
Jump DB
. 2011.
Fatty acid regulation of hepatic lipid metabolism.
.
Curr Opin Clin Nutr Metab Care. 14(2):115-20.
Hepatocytes
Tripathy S
,
Lytle KA
,
Stevens RD
,
Bain JR
,
Newgard CB
,
Greenberg AS
,
Huang L-S
,
Jump DB
. 2014.
Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice.
.
J Lipid Res. 55(7):1448-64.
Hepatitis
Jump DB
,
Depner CM
,
Tripathy S
,
Lytle KA
. 2015.
Potential for dietary ω-3 fatty acids to prevent nonalcoholic fatty liver disease and reduce the risk of primary liver cancer.
.
Adv Nutr. 6(6):694-702.
Hepatic Stellate Cells
Lytle KA
,
Depner CM
,
Wong CP
,
Jump DB
. 2015.
Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr-/- mice by targeting the TGFβ-Smad3 pathway.
.
J Lipid Res. 56(10):1936-46.
Hep G2 Cells
Tripathy S
,
Lytle KA
,
Stevens RD
,
Bain JR
,
Newgard CB
,
Greenberg AS
,
Huang L-S
,
Jump DB
. 2014.
Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice.
.
J Lipid Res. 55(7):1448-64.
Growth Differentiation Factor 15
Lytle KA
,
Wong CP
,
Jump DB
. 2017.
Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-/- mice.
.
PLoS One. 12(4):e0173376.
Glycolysis
Jump DB
. 2008.
N-3 polyunsaturated fatty acid regulation of hepatic gene transcription.
.
Curr Opin Lipidol. 19(3):242-7.
Glucose Tolerance Test
Tripathy S
,
Torres-Gonzalez M
,
Jump DB
. 2010.
Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice.
.
J Lipid Res. 51(9):2642-54.
Gluconeogenesis
Tripathy S
,
Torres-Gonzalez M
,
Jump DB
. 2010.
Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice.
.
J Lipid Res. 51(9):2642-54.
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