Linus Pauling Institute

Dashwood RH.  2007.  Frontiers in polyphenols and cancer prevention.. J Nutr. 137(1 Suppl):267S-269S.

Ellinwood DC, El-Mansy MF, Plagmann LS, Stevens JF, Maier CS, Gombart AF, Blakemore PR.  2017.  Total synthesis of [ C] -, [ C] -, and [ C] -isotopomers of xanthohumol, the principal prenylflavonoid from hops.. J Labelled Comp Radiopharm. 60(14):639-648.

Higdon JV, Frei B.  2003.  Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions.. Crit Rev Food Sci Nutr. 43(1):89-143.

Ivanov V, Carr AC, Frei B.  2001.  Red wine antioxidants bind to human lipoproteins and protect them from metal ion-dependent and -independent oxidation.. J Agric Food Chem. 49(9):4442-9.

Jamieson PE, Smart EB, Bouranis JA, Choi J, Danczak RE, Wong CP, Paraiso IL, Maier CS, Ho E, Sharpton TJ et al..  2024.  Gut enterotype-dependent modulation of gut microbiota and their metabolism in response to xanthohumol supplementation in healthy adults.. Gut Microbes. 16(1):2315633.

Kesinger NG, Stevens JF.  2009.  Covalent interaction of ascorbic acid with natural products.. Phytochemistry. 70(17-18):1930-9.

Kirkwood JS, Legette LCL, Miranda CL, Jiang Y, Stevens JF.  2013.  A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.. J Biol Chem. 288(26):19000-13.

Kirkwood JS, Maier C, Stevens JF.  2013.  Simultaneous, untargeted metabolic profiling of polar and nonpolar metabolites by LC-Q-TOF mass spectrometry.. Curr Protoc Toxicol. Chapter 4:Unit4.39.

Langley BO, Ryan JJoan, Phipps J, Buttolph L, Bray B, Aslan JE, Metz TO, Stevens JF, Bradley R.  2022.  Xanthohumol microbiome and signature in adults with Crohn's disease (the XMaS trial): a protocol for a phase II triple-masked, placebo-controlled clinical trial.. Trials. 23(1):885.

Larsen CA, Bisson WH, Dashwood RH.  2009.  Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.. J Med Chem. 52(21):6543-5.

Legette LC, Karnpracha C, Reed RL, Choi J, Bobe G, J Christensen M, Rodriguez-Proteau R, Purnell JQ, Stevens JF.  2014.  Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops.. Mol Nutr Food Res. 58(2):248-55.

Legette LC, Ma L, Reed RL, Miranda CL, Christensen JMark, Rodriguez-Proteau R, Stevens JF.  2012.  Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.. Mol Nutr Food Res. 56(3):466-74.

Legette LCL, Luna AYMoreno, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF.  2013.  Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.. Phytochemistry. 91:236-41.

Logan IE, Shulzhenko N, Sharpton TJ, Bobe G, Liu K, Nuss S, Jones ML, Miranda CL, Vasquez-Perez S, Pennington JM et al..  2021.  Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice.. Mol Nutr Food Res. 65(21):e2100389.

Lotito SB, Frei B.  2006.  Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism.. J Biol Chem. 281(48):37102-10.

Lotito SB, Frei B.  2006.  Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med. 41(12):1727-46.

Lotito SB, Zhang W-J, Yang CS, Crozier A, Frei B.  2011.  Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties.. Free Radic Biol Med. 51(2):454-63.

Lotito SB, Frei B.  2004.  The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids.. Free Radic Biol Med. 37(2):251-8.

Lotito SB, Frei B.  2004.  Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects.. Free Radic Biol Med. 36(2):201-11.

Miranda CL, Stevens JF, Ivanov V, McCall M, Frei B, Deinzer ML, Buhler DR.  2000.  Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro.. J Agric Food Chem. 48(9):3876-84.

Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF.  2016.  Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.. Arch Biochem Biophys. 599:22-30.

Peluso MR, Miranda CL, Hobbs DJ, Proteau RR, Stevens JFrederik.  2010.  Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2).. Planta Med. 76(14):1536-43.

Rajendran P, Williams DE, Ho E, Dashwood RH.  2011.  Metabolism as a key to histone deacetylase inhibition.. Crit Rev Biochem Mol Biol. 46(3):181-99.

Stevens JF, Page JE.  2004.  Xanthohumol and related prenylflavonoids from hops and beer: to your good health!. Phytochemistry. 65(10):1317-30.

Yang L, Broderick D, Campbell Y, Gombart AF, Stevens JF, Jiang Y, Hsu VL, Bisson WH, Maier CS.  2016.  Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies.. Biochim Biophys Acta. 1864(12):1667-1677.