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Biblio
Found 35 results
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Rats, Inbred F344
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2017
Chen Y-S
,
Wang R
,
Dashwood W-M
,
Löhr CV
,
Williams DE
,
Ho E
,
Mertens-Talcott S
,
Dashwood RH
. 2017.
A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat.
.
Arch Toxicol. 91(10):3415-3425.
2016
Thomas NO
,
Shay KP
,
Kelley AR
,
Butler JA
,
Hagen TM
. 2016.
Glutathione maintenance mitigates age-related susceptibility to redox cycling agents.
.
Redox Biol. 10:45-52.
Wang R
,
Kang Y
,
Löhr CV
,
Fischer KA
,
C Bradford S
,
Johnson G
,
Dashwood WMohaiza
,
Williams DE
,
Ho E
,
Dashwood RH
. 2016.
Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.
.
Cancer Lett. 381(2):341-8.
2015
Smith EJ
,
Shay KP
,
Thomas NO
,
Butler JA
,
Finlay LF
,
Hagen TM
. 2015.
Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a.
.
Free Radic Biol Med. 89:1184-91.
2012
Gómez LA
,
Heath S-HD
,
Hagen TM
. 2012.
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.
.
Mech Ageing Dev. 133(2-3):99-106.
Parasramka MA
,
W Dashwood M
,
Wang R
,
Abdelli A
,
Bailey GS
,
Williams DE
,
Ho E
,
Dashwood RH
. 2012.
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.
.
Mol Nutr Food Res. 56(8):1259-69.
Finlay LA
,
Michels AJ
,
Butler JA
,
Smith EJ
,
Monette JS
,
Moreau RF
,
Petersen SKate
,
Frei B
,
Hagen TM
. 2012.
R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.
.
Am J Physiol Regul Integr Comp Physiol. 302(5):R587-97.
2011
Wang R
,
Dashwood W-M
,
Nian H
,
Löhr CV
,
Fischer KA
,
Tsuchiya N
,
Nakagama H
,
Ashktorab H
,
Dashwood RH
. 2011.
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
.
Int J Cancer. 128(11):2581-90.
2010
Monette JS
,
Gómez LA
,
Moreau RF
,
Bemer BA
,
Taylor AW
,
Hagen TM
. 2010.
Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations.
.
Biochem Biophys Res Commun. 398(2):272-7.
Li L
,
Smith A
,
Hagen TM
,
Frei B
. 2010.
Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.
.
Ann N Y Acad Sci. 1203:151-9.
2009
Shay KPetersen
,
Hagen TM
. 2009.
Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.
.
Biogerontology. 10(4):443-56.
2008
Dixon BM
,
Heath S-HD
,
Kim R
,
Suh JH
,
Hagen TM
. 2008.
Assessment of endoplasmic reticulum glutathione redox status is confounded by extensive ex vivo oxidation.
.
Antioxid Redox Signal. 10(5):963-72.
Wang R
,
W Dashwood M
,
Löhr CV
,
Fischer KA
,
Nakagama H
,
Williams DE
,
Dashwood RH
. 2008.
beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet.
.
Cancer Sci. 99(9):1754-9.
Smith AR
,
Visioli F
,
Frei B
,
Hagen TM
. 2008.
Lipoic acid significantly restores, in rats, the age-related decline in vasomotion.
.
Br J Pharmacol. 153(8):1615-22.
Kuiper HC
,
Miranda CL
,
Sowell JD
,
Stevens JF
. 2008.
Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress.
.
J Biol Chem. 283(25):17131-8.
2007
Simonich MT
,
Egner PA
,
Roebuck BD
,
Orner GA
,
Jubert C
,
Pereira C
,
Groopman JD
,
Kensler TW
,
Dashwood RH
,
Williams DE
et al.
. 2007.
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat.
.
Carcinogenesis. 28(6):1294-302.
2006
Smith AR
,
Visioli F
,
Frei B
,
Hagen TM
. 2006.
Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.
.
Aging Cell. 5(5):391-400.
2005
Suh JH
,
Moreau R
,
Heath S-HD
,
Hagen TM
. 2005.
Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.
.
Redox Rep. 10(1):52-60.
Moreau R
,
Nguyen BT
,
Doneanu CE
,
Hagen TM
. 2005.
Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats.
.
Biochem Pharmacol. 69(1):29-40.
2004
Moreau R
,
Heath S-HD
,
Doneanu CE
,
Harris RA
,
Hagen TM
. 2004.
Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart.
.
Biochem Biophys Res Commun. 325(1):48-58.
Yu T-W
,
Xu M
,
Dashwood RH
. 2004.
Antimutagenic activity of spearmint.
.
Environ Mol Mutagen. 44(5):387-93.
Suh JH
,
Shenvi SV
,
Dixon BM
,
Liu H
,
Jaiswal AK
,
Liu R-M
,
Hagen TM
. 2004.
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.
.
Proc Natl Acad Sci U S A. 101(10):3381-6.
2003
Michels AJ
,
Joisher N
,
Hagen TM
. 2003.
Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes.
.
Arch Biochem Biophys. 410(1):112-20.
Moreau R
,
Heath S-HD
,
Doneanu CE
,
J Lindsay G
,
Hagen TM
. 2003.
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
.
Antioxid Redox Signal. 5(5):517-27.
Blum CA
,
Tanaka T
,
Zhong X
,
Li Q
,
Dashwood W-M
,
Pereira C
,
Xu M
,
Dashwood RH
. 2003.
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun.
.
Mol Carcinog. 36(4):195-203.
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