Linus Pauling Institute

Keith DJ, Butler JA, Bemer B, Dixon B, Johnson S, Garrard M, Sudakin DL, J Christensen M, Pereira C, Hagen TM.  2012.  Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study.. Pharmacol Res. 66(3):199-206.

Shay KPetersen, Hagen TM.  2009.  Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.. Biogerontology. 10(4):443-56.

Shay KPetersen, Moreau RF, Smith EJ, Hagen TM.  2008.  Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life. 60(6):362-7.

Zhang W-J, Wei H, Hagen T, Frei B.  2007.  Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway.. Proc Natl Acad Sci U S A. 104(10):4077-82.

Traber MG, Cross CE.  2023.  Alpha-Tocopherol from People to Plants Is an Essential Cog in the Metabolic Machinery.. Antioxid Redox Signal. 38(10-12):775-791.

Traber MG, Siddens LK, Leonard SW, Schock B, Gohil K, Krueger SK, Cross CE, Williams DE.  2005.  Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.. Free Radic Biol Med. 38(6):773-85.

Miranda CL, Stevens JF, Ivanov V, McCall M, Frei B, Deinzer ML, Buhler DR.  2000.  Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro.. J Agric Food Chem. 48(9):3876-84.

Frei B, McCall MR.  2001.  Antioxidant vitamins: evidence from biomarkers in humans.. Bibl Nutr Dieta. (55):46-67.

Forman HJay, Traber M, Ursini F.  2014.  Antioxidants: GRABbing new headlines.. Free Radic Biol Med. 66:1-2.

Cadenas E, Packer L, Traber MG.  2016.  Antioxidants, oxidants, and redox impacts on cell function - A tribute to Helmut Sies.. Arch Biochem Biophys. 595:94-9.

Frei B, Birlouez-Aragon I, Lykkesfeldt J.  2012.  Authors' perspective: What is the optimum intake of vitamin C in humans? Crit Rev Food Sci Nutr. 52(9):815-29.

McCall MR, Frei B.  1999.  Can antioxidant vitamins materially reduce oxidative damage in humans? Free Radic Biol Med. 26(7-8):1034-53.

Lotito SB, Frei B.  2006.  Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med. 41(12):1727-46.

Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu R-M, Hagen TM.  2004.  Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.. Proc Natl Acad Sci U S A. 101(10):3381-6.

Lotito SB, Frei B.  2006.  Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism.. J Biol Chem. 281(48):37102-10.

Lee Y, Drake AC, Thomas NO, Ferguson LG, Chappell PE, Shay KPetersen.  2018.  Dietary resveratrol increases mid-life fecundity of female Nothobranchius guentheri.. Comp Biochem Physiol C Toxicol Pharmacol. 208:71-76.

Suh JH, Moreau R, Heath S-HD, Hagen TM.  2005.  Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.. Redox Rep. 10(1):52-60.

Song Y, Chung CS, Bruno RS, Traber MG, Brown KH, King JC, Ho E.  2009.  Dietary zinc restriction and repletion affects DNA integrity in healthy men.. Am J Clin Nutr. 90(2):321-8.

Carr A, Frei B.  1999.  Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J. 13(9):1007-24.

Traber MG.  2001.  Does vitamin E decrease heart attack risk? summary and implications with respect to dietary recommendations. J Nutr. 131(2):395S-7S.

Mastaloudis A, Yu T-W, O'Donnell RP, Frei B, Dashwood RH, Traber MG.  2004.  Endurance exercise results in DNA damage as detected by the comet assay.. Free Radic Biol Med. 36(8):966-75.

Bruno RS, Leonard SW, Atkinson J, Montine TJ, Ramakrishnan R, Bray TM, Traber MG.  2006.  Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation.. Free Radic Biol Med. 40(4):689-97.

Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN.  2002.  Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.. Proc Natl Acad Sci U S A. 99(4):1870-5.

Mah E, Pei R, Guo Y, Masterjohn C, Ballard KD, Taylor BA, Taylor AW, Traber MG, Volek JS, Bruno RS.  2015.  Greater γ-tocopherol status during acute smoking abstinence with nicotine replacement therapy improved vascular endothelial function by decreasing 8-iso-15(S)-prostaglandin F2α.. Exp Biol Med (Maywood). 240(4):527-33.

Traber MG.  2007.  Heart disease and single-vitamin supplementation.. Am J Clin Nutr. 85(1):293S-299S.