Linus Pauling Institute

Gómez LA, Hagen TM.  2012.  Age-related decline in mitochondrial bioenergetics: does supercomplex destabilization determine lower oxidative capacity and higher superoxide production? Semin Cell Dev Biol. 23(7):758-67.

Suh JH, Moreau R, Heath S-HD, Hagen TM.  2005.  Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.. Redox Rep. 10(1):52-60.

Wong CP, Rinaldi NA, Ho E.  2015.  Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation.. Mol Nutr Food Res. 59(5):991-9.

Shay KPetersen, Hagen TM.  2009.  Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.. Biogerontology. 10(4):443-56.

Zamzow DR, Elias V, Legette LCL, Choi J, J Stevens F, Magnusson KR.  2014.  Xanthohumol improved cognitive flexibility in young mice.. Behav Brain Res. 275:1-10.

Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, Hagen TM.  2001.  Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid.. FASEB J. 15(3):700-6.

Smith AR, Visioli F, Frei B, Hagen TM.  2006.  Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.. Aging Cell. 5(5):391-400.

Smith AR, Visioli F, Frei B, Hagen TM.  2008.  Lipoic acid significantly restores, in rats, the age-related decline in vasomotion.. Br J Pharmacol. 153(8):1615-22.

Smith AR, Visioli F, Hagen TM.  2006.  Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age.. Arch Biochem Biophys. 454(1):100-5.

Moreau R, Heath S-HD, Doneanu CE, J Lindsay G, Hagen TM.  2003.  Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.. Antioxid Redox Signal. 5(5):517-27.

Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu R-M, Hagen TM.  2004.  Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.. Proc Natl Acad Sci U S A. 101(10):3381-6.

Thomas NO, Shay KP, Kelley AR, Butler JA, Hagen TM.  2016.  Glutathione maintenance mitigates age-related susceptibility to redox cycling agents.. Redox Biol. 10:45-52.

Suh JH, Heath S-H, Hagen TM.  2003.  Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress.. Free Radic Biol Med. 35(9):1064-72.

Fleming JE, Reveillaud I, Niedzwiecki A.  1992.  Role of oxidative stress in Drosophila aging.. Mutat Res. 275(3-6):267-79.

Hagen TM, Moreau R, Suh JH, Visioli F.  2002.  Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.. Ann N Y Acad Sci. 959:491-507.

Iwaniec UT, Turner RT, Smith BJ, Stoecker BJ, Rust A, Zhang B, Vasu VT, Gohil K, Cross CE, Traber MG.  2013.  Evaluation of long-term vitamin E insufficiency or excess on bone mass, density, and microarchitecture in rodents.. Free Radic Biol Med. 65:1209-1214.

Moreau R, Heath S-HD, Doneanu CE, Harris RA, Hagen TM.  2004.  Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart.. Biochem Biophys Res Commun. 325(1):48-58.

Michels AJ, Joisher N, Hagen TM.  2003.  Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes.. Arch Biochem Biophys. 410(1):112-20.

Niedzwiecki A, Reveillaud I, Fleming JE.  1992.  Changes in superoxide dismutase and catalase in aging heat-shocked Drosophila.. Free Radic Res Commun. 17(6):355-67.

Moreau R, Nguyen BT, Doneanu CE, Hagen TM.  2005.  Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats.. Biochem Pharmacol. 69(1):29-40.

Smith EJ, Shay KP, Thomas NO, Butler JA, Finlay LF, Hagen TM.  2015.  Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a.. Free Radic Biol Med. 89:1184-91.

Smith AR, Hagen TM.  2003.  Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid.. Biochem Soc Trans. 31(Pt 6):1447-9.

Wang R, Yu Z, Sunchu B, Shoaf J, Dang I, Zhao S, Caples K, Bradley L, Beaver LM, Ho E et al..  2017.  Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.. Aging Cell. 16(3):564-574.

Netke SP, Roomi MW, Tsao C, Niedzwiecki A.  1997.  Ascorbic acid protects guinea pigs from acute aflatoxin toxicity.. Toxicol Appl Pharmacol. 143(2):429-35.

Kubglomsong S, Theerakulkait C, Reed RL, Yang L, Maier CS, Stevens JF.  2018.  Isolation and Identification of Tyrosinase-Inhibitory and Copper-Chelating Peptides from Hydrolyzed Rice-Bran-Derived Albumin.. J Agric Food Chem. 66(31):8346-8354.