Found 610 results
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Humans
Palomera-Sanchez Z, Watson GW, Wong CP, Beaver LM, Williams DE, Dashwood RH, Ho E.  2017.  The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells.. J Nutr Biochem. 47:113-119.
Williams DE.  2018.  Association Is Not Causation.. Toxicol Sci. 164(1):3.
Maier MLVermilli, Siddens LK, Pennington JM, Uesugi SL, Labut EM, Vertel EA, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ et al..  2023.  Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing.. Chem Biol Interact. 382:110608.
Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, E Houseman A, Williams DE, Dashwood RH, Ho E.  2014.  Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.. PLoS One. 9(1):e86787.
Watson GW, Wickramasekara S, Fang Y, Palomera-Sanchez Z, Maier CS, Williams DE, Dashwood RH, Perez VI, Ho E.  2015.  Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells.. Mol Nutr Food Res. 59(10):1954-61.
Rajendran P, Williams DE, Ho E, Dashwood RH.  2011.  Metabolism as a key to histone deacetylase inhibition.. Crit Rev Biochem Mol Biol. 46(3):181-99.
Krueger SK, Williams DE, Yueh M-F, Martin SR, Hines RN, Raucy JL, Dolphin CT, Shephard EA, Phillips IR.  2002.  Genetic polymorphisms of flavin-containing monooxygenase (FMO).. Drug Metab Rev. 34(3):523-32.
Maier MLVermilli, Siddens LK, Pennington JM, Uesugi SL, Anderson KA, Tidwell LG, Tilton SC, Ognibene TJ, Turteltaub KW, Smith JN et al..  2022.  Benzo[a]pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with [C]-BaP.. Environ Int. 159:107045.
Hummel JM, Madeen EP, Siddens LK, Uesugi SL, McQuistan T, Anderson KA, Turteltaub KW, Ognibene TJ, Bench G, Krueger SK et al..  2018.  Pharmacokinetics of [C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction.. Food Chem Toxicol. 115:136-147.
Krueger SK, Martin SR, Yueh M-F, Pereira CB, Williams DE.  2002.  Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein.. Drug Metab Dispos. 30(1):34-41.
Chimploy K, G Díaz D, Li Q, Carter O, Dashwood W-M, Mathews CK, Williams DE, Bailey GS, Dashwood RH.  2009.  E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.. Int J Cancer. 125(9):2086-94.
Henderson MC, Krueger SK, Stevens JF, Williams DE.  2004.  Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione.. Chem Res Toxicol. 17(5):633-40.
Parasramka MA, Ho E, Williams DE, Dashwood RH.  2012.  MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals.. Mol Carcinog. 51(3):213-30.
Ho E, Beaver LM, Williams DE, Dashwood RH.  2011.  Dietary factors and epigenetic regulation for prostate cancer prevention.. Adv Nutr. 2(6):497-510.
Higdon JV, Delage B, Williams DE, Dashwood RH.  2007.  Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.. Pharmacol Res. 55(3):224-36.
Wang R, Kang Y, Löhr CV, Fischer KA, C Bradford S, Johnson G, Dashwood WMohaiza, Williams DE, Ho E, Dashwood RH.  2016.  Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.. Cancer Lett. 381(2):341-8.
Beaver LM, Kuintzle R, Buchanan A, Wiley MW, Glasser ST, Wong CP, Johnson GS, Chang JH, Löhr CV, Williams DE et al..  2017.  Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer.. J Nutr Biochem. 42:72-83.
Traber MG, Siddens LK, Leonard SW, Schock B, Gohil K, Krueger SK, Cross CE, Williams DE.  2005.  Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.. Free Radic Biol Med. 38(6):773-85.
Johnson GS, Li J, Beaver LM, W Dashwood M, Sun D, Rajendran P, Williams DE, Ho E, Dashwood RH.  2017.  A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells.. Mol Nutr Food Res. 61(4)
Harper TA, Morré J, Lauer FT, McQuistan TJ, Hummel JM, Burchiel SW, Williams DE.  2015.  Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS.. Mutat Res Genet Toxicol Environ Mutagen. 782:51-6.
Bouranis JA, Beaver LM, Jiang D, Choi J, Wong CP, Davis EW, Williams DE, Sharpton TJ, Stevens JF, Ho E.  2022.  Interplay between Cruciferous Vegetables and the Gut Microbiome: A Multi-Omic Approach.. Nutrients. 15(1)
Krueger SK, VanDyke JE, Williams DE, Hines RN.  2006.  The role of flavin-containing monooxygenase (FMO) in the metabolism of tamoxifen and other tertiary amines.. Drug Metab Rev. 38(1-2):139-47.
Maier MLVermilli, Siddens LK, Pennington JM, Uesugi SL, Tilton SC, Vertel EA, Anderson KA, Tidwell LG, Ognibene TJ, Turteltaub KW et al..  2023.  Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts.. Toxicol Appl Pharmacol. 460:116377.
Bailey GS, Reddy AP, Pereira CB, Harttig U, Baird W, Spitsbergen JM, Hendricks JD, Orner GA, Williams DE, Swenberg JA.  2009.  Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study.. Chem Res Toxicol. 22(7):1264-76.
Madeen EP, Löhr CV, You H, Siddens LK, Krueger SK, Dashwood RH, Gonzalez FJ, Baird WM, Ho E, Bramer L et al..  2017.  Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.. Mol Carcinog. 56(1):163-171.

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