Linus Pauling Institute

Carr AC, Hawkins CL, Thomas SR, Stocker R, Frei B.  2001.  Relative reactivities of N-chloramines and hypochlorous acid with human plasma constituents.. Free Radic Biol Med. 30(5):526-36.

Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN.  2002.  Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.. Proc Natl Acad Sci U S A. 99(4):1870-5.

Miranda CL, Reed RL, Kuiper HC, Alber S, Stevens JF.  2009.  Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells.. Chem Res Toxicol. 22(5):863-74.

Harakeh S, Niedzwiecki A, Jariwalla RJ.  1994.  Mechanistic aspects of ascorbate inhibition of human immunodeficiency virus.. Chem Biol Interact. 91(2-3):207-15.

Carr AC, Frei B.  2002.  Human neutrophils oxidize low-density lipoprotein by a hypochlorous acid-dependent mechanism: the role of vitamin C.. Biol Chem. 383(3-4):627-36.

Michels AJ, Frei B.  2013.  Myths, artifacts, and fatal flaws: identifying limitations and opportunities in vitamin C research.. Nutrients. 5(12):5161-92.

Roomi MW, House D, Tsao CS.  1998.  Cytotoxic effect of substitution at 2-, 6-, and 2,6-positions in ascorbic acid on malignant cell line.. Cancer Biochem Biophys. 16(4):295-300.

Bruno RS, Leonard SW, Atkinson J, Montine TJ, Ramakrishnan R, Bray TM, Traber MG.  2006.  Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation.. Free Radic Biol Med. 40(4):689-97.

Kesinger NG, Stevens JF.  2009.  Covalent interaction of ascorbic acid with natural products.. Phytochemistry. 70(17-18):1930-9.

Sowell J, Frei B, Stevens JF.  2004.  Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma.. Proc Natl Acad Sci U S A. 101(52):17964-9.

Netke SP, Roomi MW, Tsao C, Niedzwiecki A.  1997.  Ascorbic acid protects guinea pigs from acute aflatoxin toxicity.. Toxicol Appl Pharmacol. 143(2):429-35.

Roomi MW, Ogg M, Tsao CS, Gibson GG.  1997.  Ascorbic acid deficiency decreases the expression of CYP4A1 in liver microsomes of guinea pigs.. Res Commun Mol Pathol Pharmacol. 95(1):3-10.

Mastaloudis A, Leonard SW, Traber MG.  2001.  Oxidative stress in athletes during extreme endurance exercise.. Free Radic Biol Med. 31(7):911-22.

Traber MG.  2007.  Heart disease and single-vitamin supplementation.. Am J Clin Nutr. 85(1):293S-299S.

Roomi MW.  1997.  Association between hyperlipidemia and hepatic cytochrome P-450 in guinea pigs.. Res Commun Mol Pathol Pharmacol. 97(2):139-50.

Frei B, Birlouez-Aragon I, Lykkesfeldt J.  2012.  Authors' perspective: What is the optimum intake of vitamin C in humans? Crit Rev Food Sci Nutr. 52(9):815-29.

Harakeh S, Jariwalla RJ.  1997.  NF-kappa B-independent suppression of HIV expression by ascorbic acid.. AIDS Res Hum Retroviruses. 13(3):235-9.

Frei B, Lawson S.  2008.  Vitamin C and cancer revisited.. Proc Natl Acad Sci U S A. 105(32):11037-8.

Zhu B-Z, Antholine WE, Frei B.  2002.  Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex.. Free Radic Biol Med. 32(12):1333-8.

Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, Hagen TM.  2001.  Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid.. FASEB J. 15(3):700-6.

Carr A, Frei B.  1999.  Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J. 13(9):1007-24.

Michels AJ, Hagen TM, Frei B.  2013.  Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.. Annu Rev Nutr. 33:45-70.

Carr AC.  2001.  Hypochlorous acid-modified low-density lipoprotein inactivates the lysosomal protease cathepsin B: protection by ascorbic and lipoic acids.. Redox Rep. 6(6):343-9.

Carr AC, Frei B.  1999.  Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans.. Am J Clin Nutr. 69(6):1086-107.

Frei B.  1999.  On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction.. Proc Soc Exp Biol Med. 222(3):196-204.