Found 324 results
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Survival Analysis
Hilton JB, Mercer SW, Lim NKH, Faux NG, Buncic G, Beckman JS, Roberts BR, Donnelly PS, White AR, Crouch PJ.  2017.  Cu(atsm) improves the neurological phenotype and survival of SOD1 mice and selectively increases enzymatically active SOD1 in the spinal cord.. Sci Rep. 7:42292.
Superoxides
Robinson KM, Janes MS, Beckman JS.  2008.  The selective detection of mitochondrial superoxide by live cell imaging.. Nat Protoc. 3(6):941-7.
Robinson KM, Janes MS, Pehar M, Monette JS, Ross MF, Hagen TM, Murphy MP, Beckman JS.  2006.  Selective fluorescent imaging of superoxide in vivo using ethidium-based probes.. Proc Natl Acad Sci U S A. 103(41):15038-43.
Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ et al..  2014.  The 'mitoflash' probe cpYFP does not respond to superoxide.. Nature. 514(7523):E12-4.
Beckman JS.  2002.  Protein tyrosine nitration and peroxynitrite.. FASEB J. 16(9):1144.
Beckman JS.  2009.  Understanding peroxynitrite biochemistry and its potential for treating human diseases.. Arch Biochem Biophys. 484(2):114-6.
Superoxide Dismutase-1
Kovacs M, Trias E, Varela V, Ibarburu S, Beckman JS, Moura IC, Hermine O, King PH, Si Y, Kwon Y et al..  2019.  CD34 Identifies a Subset of Proliferating Microglial Cells Associated with Degenerating Motor Neurons in ALS.. Int J Mol Sci. 20(16)
Liddell JR, Hilton JBW, Kysenius K, Billings JL, Nikseresht S, McInnes LE, Hare DJ, Paul B, Mercer SW, Belaidi AA et al..  2024.  Microglial ferroptotic stress causes non-cell autonomous neuronal death.. Mol Neurodegener. 19(1):14.
Hilton JBW, Kysenius K, Liddell JR, Mercer SW, Paul B, Beckman JS, McLean CA, White AR, Donnelly PS, Bush AI et al..  2024.  Evidence for disrupted copper availability in human spinal cord supports Cu(atsm) as a treatment option for sporadic cases of ALS.. Sci Rep. 14(1):5929.
Superoxide Dismutase
Wei H, Frei B, Beckman JS, Zhang W-J.  2011.  Copper chelation by tetrathiomolybdate inhibits lipopolysaccharide-induced inflammatory responses in vivo.. Am J Physiol Heart Circ Physiol. 301(3):H712-20.
Leinweber B, Barofsky E, Barofsky DF, Ermilov V, Nylin K, Beckman JS.  2004.  Aggregation of ALS mutant superoxide dismutase expressed in Escherichia coli.. Free Radic Biol Med. 36(7):911-8.
Hilton JBW, Kysenius K, Liddell JR, Mercer SW, Paul B, Beckman JS, McLean CA, White AR, Donnelly PS, Bush AI et al..  2024.  Evidence for disrupted copper availability in human spinal cord supports Cu(atsm) as a treatment option for sporadic cases of ALS.. Sci Rep. 14(1):5929.
Trumbull KA, Beckman JS.  2009.  A role for copper in the toxicity of zinc-deficient superoxide dismutase to motor neurons in amyotrophic lateral sclerosis.. Antioxid Redox Signal. 11(7):1627-39.
Beckman JS.  2009.  Understanding peroxynitrite biochemistry and its potential for treating human diseases.. Arch Biochem Biophys. 484(2):114-6.
Williams JR, Trias E, Beilby PR, Lopez NI, Labut EM, C Bradford S, Roberts BR, McAllum EJ, Crouch PJ, Rhoads TW et al..  2016.  Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD.. Neurobiol Dis. 89:1-9.
Trias E, Ibarburu S, Barreto-Núñez R, Babdor J, Maciel TT, Guillo M, Gros L, Dubreuil P, Díaz-Amarilla P, Cassina P et al..  2016.  Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis.. J Neuroinflammation. 13(1):177.
Ermilova IP, Ermilov VB, Levy M, Ho E, Pereira C, Beckman JS.  2005.  Protection by dietary zinc in ALS mutant G93A SOD transgenic mice.. Neurosci Lett. 379(1):42-6.
Beckman JS, Esétvez AG, Barbeito L, Crow JP.  2002.  CCS knockout mice establish an alternative source of copper for SOD in ALS.. Free Radic Biol Med. 33(10):1433-5.
Robinson KM, Janes MS, Beckman JS.  2008.  The selective detection of mitochondrial superoxide by live cell imaging.. Nat Protoc. 3(6):941-7.
Hilton JB, Mercer SW, Lim NKH, Faux NG, Buncic G, Beckman JS, Roberts BR, Donnelly PS, White AR, Crouch PJ.  2017.  Cu(atsm) improves the neurological phenotype and survival of SOD1 mice and selectively increases enzymatically active SOD1 in the spinal cord.. Sci Rep. 7:42292.
Trumbull KA, McAllister D, Gandelman MM, Fung WY, Lew T, Brennan L, Lopez N, Morré J, Kalyanaraman B, Beckman JS.  2012.  Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice.. Neurobiol Dis. 45(1):137-44.
Substance P
Fort KL, Cramer CN, Voinov VG, Vasil'ev YV, Lopez NI, Beckman JS, Heck AJR.  2018.  Exploring ECD on a Benchtop Q Exactive Orbitrap Mass Spectrometer.. J Proteome Res. 17(2):926-933.
Spinal Cord
Kovacs M, Trias E, Varela V, Ibarburu S, Beckman JS, Moura IC, Hermine O, King PH, Si Y, Kwon Y et al..  2019.  CD34 Identifies a Subset of Proliferating Microglial Cells Associated with Degenerating Motor Neurons in ALS.. Int J Mol Sci. 20(16)
Hilton JBW, Kysenius K, Liddell JR, Mercer SW, Paul B, Beckman JS, McLean CA, White AR, Donnelly PS, Bush AI et al..  2024.  Evidence for disrupted copper availability in human spinal cord supports Cu(atsm) as a treatment option for sporadic cases of ALS.. Sci Rep. 14(1):5929.
Williams JR, Trias E, Beilby PR, Lopez NI, Labut EM, C Bradford S, Roberts BR, McAllum EJ, Crouch PJ, Rhoads TW et al..  2016.  Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD.. Neurobiol Dis. 89:1-9.

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