Linus Pauling Institute

Li L, Smith A, Hagen TM, Frei B.  2010.  Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.. Ann N Y Acad Sci. 1203:151-9.

Zhang W-J, Wei H, Frei B.  2009.  Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo.. Free Radic Biol Med. 46(6):791-8.

Li L, Frei B.  2009.  Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamine.. Arterioscler Thromb Vasc Biol. 29(5):732-8.

Zhang W-J, Bird KE, McMillen TS, Leboeuf RC, Hagen TM, Frei B.  2008.  Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice.. Circulation. 117(3):421-8.

Frei B, Lawson S.  2008.  Vitamin C and cancer revisited.. Proc Natl Acad Sci U S A. 105(32):11037-8.

Traber MG, Frei B, Beckman JS.  2008.  Vitamin E revisited: do new data validate benefits for chronic disease prevention? Curr Opin Lipidol. 19(1):30-8.

Zhang W-J, Wei H, Hagen T, Frei B.  2007.  Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway.. Proc Natl Acad Sci U S A. 104(10):4077-82.

Smith AR, Visioli F, Frei B, Hagen TM.  2006.  Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.. Aging Cell. 5(5):391-400.

Taylor AW, Bruno RS, Frei B, Traber MG.  2006.  Benefits of prolonged gradient separation for high-performance liquid chromatography-tandem mass spectrometry quantitation of plasma total 15-series F-isoprostanes.. Anal Biochem. 350(1):41-51.

Higdon JV, Frei B.  2006.  Coffee and health: a review of recent human research.. Crit Rev Food Sci Nutr. 46(2):101-23.

Lotito SB, Frei B.  2006.  Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med. 41(12):1727-46.

Lotito SB, Frei B.  2006.  Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism.. J Biol Chem. 281(48):37102-10.

Li L, Frei B.  2006.  Iron chelation inhibits NF-kappaB-mediated adhesion molecule expression by inhibiting p22(phox) protein expression and NADPH oxidase activity.. Arterioscler Thromb Vasc Biol. 26(12):2638-43.

Higdon JV, Frei B.  2005.  Is there a gender difference in the effect of antioxidants on cancer risk? Br J Nutr. 94(2):139-40.

Mastaloudis A, Yu T-W, O'Donnell RP, Frei B, Dashwood RH, Traber MG.  2004.  Endurance exercise results in DNA damage as detected by the comet assay.. Free Radic Biol Med. 36(8):966-75.

Lotito SB, Frei B.  2004.  The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids.. Free Radic Biol Med. 37(2):251-8.

Lotito SB, Frei B.  2004.  Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects.. Free Radic Biol Med. 36(2):201-11.

Sowell J, Frei B, Stevens JF.  2004.  Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma.. Proc Natl Acad Sci U S A. 101(52):17964-9.

Zhang WJian, Frei B.  2003.  Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells.. Free Radic Biol Med. 34(6):674-82.

Higdon JV, Frei B.  2003.  Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions.. Crit Rev Food Sci Nutr. 43(1):89-143.

Zhang W-J, Frei B.  2002.  Albumin selectively inhibits TNF alpha-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells.. Cardiovasc Res. 55(4):820-9.

Carr AC, Frei B.  2002.  Human neutrophils oxidize low-density lipoprotein by a hypochlorous acid-dependent mechanism: the role of vitamin C.. Biol Chem. 383(3-4):627-36.

Zhang WJian, Stocker R, McCall MR, Forte TM, Frei B.  2002.  Lack of inhibitory effect of HDL on TNFalpha-induced adhesion molecule expression in human aortic endothelial cells.. Atherosclerosis. 165(2):241-9.

Visioli F, Smith A, Zhang W, Keaney JF, Hagen T, Frei B.  2002.  Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status.. Redox Rep. 7(4):223-7.

Zhu B-Z, Zhao H-T, Kalyanaraman B, Frei B.  2002.  Metal-independent production of hydroxyl radicals by halogenated quinones and hydrogen peroxide: an ESR spin trapping study.. Free Radic Biol Med. 32(5):465-73.