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Dashwood, Roderick H
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Amines
Dashwood RH
. 2002.
Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models.
.
Mutat Res. 511(2):89-112.
Chen Y-S
,
Wang R
,
Dashwood W-M
,
Löhr CV
,
Williams DE
,
Ho E
,
Mertens-Talcott S
,
Dashwood RH
. 2017.
A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat.
.
Arch Toxicol. 91(10):3415-3425.
Amino Acid Sequence
Li Q
,
Dixon BM
,
Al-Fageeh M
,
Blum CA
,
Dashwood RH
. 2002.
Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline.
.
Gene. 283(1-2):255-62.
Amino Acid Substitution
Al-Fageeh M
,
Li Q
,
W Dashwood M
,
Myzak MC
,
Dashwood RH
. 2004.
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.
.
Oncogene. 23(28):4839-46.
Analysis of Variance
Wong CP
,
Hsu A
,
Buchanan A
,
Palomera-Sanchez Z
,
Beaver LM
,
E Houseman A
,
Williams DE
,
Dashwood RH
,
Ho E
. 2014.
Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.
.
PLoS One. 9(1):e86787.
Androgen Receptor Antagonists
Palomera-Sanchez Z
,
Watson GW
,
Wong CP
,
Beaver LM
,
Williams DE
,
Dashwood RH
,
Ho E
. 2017.
The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells.
.
J Nutr Biochem. 47:113-119.
Androgens
Beaver LM
,
Yu T-W
,
Sokolowski EI
,
Williams DE
,
Dashwood RH
,
Ho E
. 2012.
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells.
.
Toxicol Appl Pharmacol. 263(3):345-51.
Myzak MC
,
Hardin K
,
Wang R
,
Dashwood RH
,
Ho E
. 2006.
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells.
.
Carcinogenesis. 27(4):811-9.
Animal Feed
McQuistan TJ
,
Simonich MT
,
M Pratt M
,
Pereira CB
,
Hendricks JD
,
Dashwood RH
,
Williams DE
,
Bailey GS
. 2012.
Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study.
.
Food Chem Toxicol. 50(2):341-52.
Animals
Myzak MC
,
Tong P
,
Dashwood W-M
,
Dashwood RH
,
Ho E
. 2007.
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.
.
Exp Biol Med (Maywood). 232(2):227-34.
Orner GA
,
Dashwood W-M
,
Blum CA
,
G Díaz D
,
Li Q
,
Al-Fageeh M
,
Tebbutt N
,
Heath JK
,
Ernst M
,
Dashwood RH
. 2002.
Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
.
Mutat Res. 506-507:121-7.
Larsen CA
,
Dashwood RH
,
Bisson WH
. 2010.
Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance.
.
Pharmacol Res. 62(6):457-64.
Dashwood RH
. 2002.
Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models.
.
Mutat Res. 511(2):89-112.
Blum CA
,
Tanaka T
,
Zhong X
,
Li Q
,
Dashwood W-M
,
Pereira C
,
Xu M
,
Dashwood RH
. 2003.
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun.
.
Mol Carcinog. 36(4):195-203.
Al-Fageeh M
,
Li Q
,
W Dashwood M
,
Myzak MC
,
Dashwood RH
. 2004.
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.
.
Oncogene. 23(28):4839-46.
Li Q
,
Löhr CV
,
Dashwood RH
. 2009.
Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse.
.
Cancer Lett. 283(1):36-42.
Wang R
,
Kang Y
,
Löhr CV
,
Fischer KA
,
C Bradford S
,
Johnson G
,
Dashwood WMohaiza
,
Williams DE
,
Ho E
,
Dashwood RH
. 2016.
Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.
.
Cancer Lett. 381(2):341-8.
Li Q
,
Dixon BM
,
Al-Fageeh M
,
Blum CA
,
Dashwood RH
. 2002.
Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline.
.
Gene. 283(1-2):255-62.
Dashwood RH
,
Ho E
. 2008.
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates.
.
Nutr Rev. 66 Suppl 1:S36-8.
Dashwood RH
. 2003.
Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis.
.
J Biochem Mol Biol. 36(1):35-42.
Simonich MT
,
McQuistan T
,
Jubert C
,
Pereira C
,
Hendricks JD
,
Schimerlik M
,
Zhu B
,
Dashwood RH
,
Williams DE
,
Bailey GS
. 2008.
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout.
.
Food Chem Toxicol. 46(3):1014-24.
Parasramka MA
,
Ho E
,
Williams DE
,
Dashwood RH
. 2012.
MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals.
.
Mol Carcinog. 51(3):213-30.
Blum CA
,
Xu M
,
Orner GA
,
G Díaz D
,
Li Q
,
Dashwood WMohaiza
,
Bailey GS
,
Dashwood RH
. 2003.
Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling.
.
Mutat Res. 523-524:217-23.
Wang R
,
Dashwood W-M
,
Nian H
,
Löhr CV
,
Fischer KA
,
Tsuchiya N
,
Nakagama H
,
Ashktorab H
,
Dashwood RH
. 2011.
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
.
Int J Cancer. 128(11):2581-90.
Orner GA
,
Dashwood W-M
,
Dashwood RH
. 2004.
Tumor-suppressing effects of antioxidants from tea.
.
J Nutr. 134(11):3177S-3178S.
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