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Faculty and Staff
Our Research
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Biblio
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Dashwood, Roderick H
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Mastaloudis A
,
Yu T-W
,
O'Donnell RP
,
Frei B
,
Dashwood RH
,
Traber MG
. 2004.
Endurance exercise results in DNA damage as detected by the comet assay.
.
Free Radic Biol Med. 36(8):966-75.
Larsen CA
,
Dashwood RH
. 2010.
(-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells.
.
Arch Biochem Biophys. 501(1):52-7.
Wang R
,
Löhr CV
,
Fischer K
,
W Dashwood M
,
Greenwood JA
,
Ho E
,
Williams DE
,
Ashktorab H
,
Dashwood MR
,
Dashwood RH
. 2013.
Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.
.
Int J Cancer. 132(5):1004-12.
Atwell LL
,
Beaver LM
,
Shannon J
,
Williams DE
,
Dashwood RH
,
Ho E
. 2015.
Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention.
.
Curr Pharmacol Rep. 1(2):102-111.
F
Dashwood RH
. 2007.
Frontiers in polyphenols and cancer prevention.
.
J Nutr. 137(1 Suppl):267S-269S.
Johnson GS
,
Li J
,
Beaver LM
,
W Dashwood M
,
Sun D
,
Rajendran P
,
Williams DE
,
Ho E
,
Dashwood RH
. 2017.
A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells.
.
Mol Nutr Food Res. 61(4)
H
Rajendran P
,
Kidane AI
,
Yu T-W
,
Dashwood W-M
,
Bisson WH
,
Löhr CV
,
Ho E
,
Williams DE
,
Dashwood RH
. 2013.
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.
.
Epigenetics. 8(6):612-23.
Watson GW
,
Wickramasekara S
,
Fang Y
,
Maier CS
,
Williams DE
,
Dashwood RH
,
Perez VI
,
Ho E
. 2016.
HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells.
.
Exp Biol Med (Maywood). 241(11):1177-85.
Myzak MC
,
Dashwood RH
. 2006.
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane.
.
Curr Drug Targets. 7(4):443-52.
I
Dashwood W-M
,
Orner GA
,
Dashwood RH
. 2002.
Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations.
.
Biochem Biophys Res Commun. 296(3):584-8.
L
Beaver LM
,
Kuintzle R
,
Buchanan A
,
Wiley MW
,
Glasser ST
,
Wong CP
,
Johnson GS
,
Chang JH
,
Löhr CV
,
Williams DE
et al.
. 2017.
Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer.
.
J Nutr Biochem. 42:72-83.
Simonich MT
,
McQuistan T
,
Jubert C
,
Pereira C
,
Hendricks JD
,
Schimerlik M
,
Zhu B
,
Dashwood RH
,
Williams DE
,
Bailey GS
. 2008.
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout.
.
Food Chem Toxicol. 46(3):1014-24.
Dashwood W-M
,
Carter O
,
Al-Fageeh M
,
Li Q
,
Dashwood RH
. 2005.
Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate.
.
Mutat Res. 591(1-2):161-72.
M
Rajendran P
,
Williams DE
,
Ho E
,
Dashwood RH
. 2011.
Metabolism as a key to histone deacetylase inhibition.
.
Crit Rev Biochem Mol Biol. 46(3):181-99.
Parasramka MA
,
W Dashwood M
,
Wang R
,
Abdelli A
,
Bailey GS
,
Williams DE
,
Ho E
,
Dashwood RH
. 2012.
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.
.
Mol Nutr Food Res. 56(8):1259-69.
Parasramka MA
,
Ho E
,
Williams DE
,
Dashwood RH
. 2012.
MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals.
.
Mol Carcinog. 51(3):213-30.
Chen Y-S
,
Wang R
,
Dashwood W-M
,
Löhr CV
,
Williams DE
,
Ho E
,
Mertens-Talcott S
,
Dashwood RH
. 2017.
A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat.
.
Arch Toxicol. 91(10):3415-3425.
Dashwood RH
. 2002.
Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models.
.
Mutat Res. 511(2):89-112.
Nian H
,
Delage B
,
Ho E
,
Dashwood RH
. 2009.
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds.
.
Environ Mol Mutagen. 50(3):213-21.
Blum CA
,
Tanaka T
,
Zhong X
,
Li Q
,
Dashwood W-M
,
Pereira C
,
Xu M
,
Dashwood RH
. 2003.
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun.
.
Mol Carcinog. 36(4):195-203.
N
Wang R
,
Dashwood W-M
,
Nian H
,
Löhr CV
,
Fischer KA
,
Tsuchiya N
,
Nakagama H
,
Ashktorab H
,
Dashwood RH
. 2011.
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
.
Int J Cancer. 128(11):2581-90.
Simonich MT
,
Egner PA
,
Roebuck BD
,
Orner GA
,
Jubert C
,
Pereira C
,
Groopman JD
,
Kensler TW
,
Dashwood RH
,
Williams DE
et al.
. 2007.
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat.
.
Carcinogenesis. 28(6):1294-302.
Myzak MC
,
P Karplus A
,
Chung F-L
,
Dashwood RH
. 2004.
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.
.
Cancer Res. 64(16):5767-74.
Rajendran P
,
Dashwood W-M
,
Li L
,
Kang Y
,
Kim E
,
Johnson G
,
Fischer KA
,
Löhr CV
,
Williams DE
,
Ho E
et al.
. 2015.
Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.
.
Clin Epigenetics. 7:102.
P
Al-Fageeh M
,
Li Q
,
W Dashwood M
,
Myzak MC
,
Dashwood RH
. 2004.
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.
.
Oncogene. 23(28):4839-46.
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