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About the LPI
Faculty and Staff
Our Research
Micronutrient Information
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Biblio
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Oxygen
Hagen TM
,
Moreau R
,
Suh JH
,
Visioli F
. 2002.
Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.
.
Ann N Y Acad Sci. 959:491-507.
Oxidoreductases, N-Demethylating
Traber MG
,
Siddens LK
,
Leonard SW
,
Schock B
,
Gohil K
,
Krueger SK
,
Cross CE
,
Williams DE
. 2005.
Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.
.
Free Radic Biol Med. 38(6):773-85.
Oxidoreductases
Michels AJ
,
Hagen TM
,
Frei B
. 2013.
Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.
.
Annu Rev Nutr. 33:45-70.
Yu T-W
,
Xu M
,
Dashwood RH
. 2004.
Antimutagenic activity of spearmint.
.
Environ Mol Mutagen. 44(5):387-93.
Carr A
,
Frei B
. 1999.
Does vitamin C act as a pro-oxidant under physiological conditions?
FASEB J. 13(9):1007-24.
Santana-Rios G
,
Orner GA
,
Amantana A
,
Provost C
,
Wu SY
,
Dashwood RH
. 2001.
Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay.
.
Mutat Res. 495(1-2):61-74.
Chagani S
,
Kyryachenko S
,
Yamamoto Y
,
Kato S
,
Ganguli-Indra G
,
Indra AK
. 2016.
In Vivo Role of Vitamin D Receptor Signaling in UVB-Induced DNA Damage and Melanocyte Homeostasis.
.
J Invest Dermatol. 136(10):2108-2111.
Oxides
Robinson KM
,
Beckman JS
. 2005.
Synthesis of peroxynitrite from nitrite and hydrogen peroxide.
.
Methods Enzymol. 396:207-14.
Oxidative Stress
Zhu B-Z
,
Antholine WE
,
Frei B
. 2002.
Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex.
.
Free Radic Biol Med. 32(12):1333-8.
Lebold KM
,
Löhr CV
,
Barton CL
,
Miller GW
,
Labut EM
,
Tanguay RL
,
Traber MG
. 2013.
Chronic vitamin E deficiency promotes vitamin C deficiency in zebrafish leading to degenerative myopathy and impaired swimming behavior.
.
Comp Biochem Physiol C Toxicol Pharmacol. 157(4):382-9.
Maciel-Barón LÁngel
,
Morales-Rosales SLizbeth
,
Silva-Palacios A
,
Rodríguez-Barrera RHaydee
,
García-Álvarez JAntonio
,
Luna-López A
,
Pérez VIsabel
,
Torres C
,
Königsberg M
. 2018.
The secretory phenotype of senescent astrocytes isolated from Wistar newborn rats changes with anti-inflammatory drugs, but does not have a short-term effect on neuronal mitochondrial potential.
.
Biogerontology. 19(5):415-433.
Traber MG
,
Atkinson J
. 2007.
Vitamin E, antioxidant and nothing more.
.
Free Radic Biol Med. 43(1):4-15.
Pei R
,
Mah E
,
Leonard SW
,
Traber MG
,
Bruno RS
. 2015.
α-Tocopherol supplementation reduces 5-nitro-γ-tocopherol accumulation by decreasing γ-tocopherol in young adult smokers.
.
Free Radic Res. 49(9):1114-1121.
Mah E
,
Pei R
,
Guo Y
,
Ballard KD
,
Barker T
,
Rogers VE
,
Parker BA
,
Taylor AW
,
Traber MG
,
Volek JS
et al.
. 2013.
γ-Tocopherol-rich supplementation additively improves vascular endothelial function during smoking cessation.
.
Free Radic Biol Med. 65:1291-1299.
McCall MR
,
Frei B
. 1999.
Can antioxidant vitamins materially reduce oxidative damage in humans?
Free Radic Biol Med. 26(7-8):1034-53.
Shay KPetersen
,
Hagen TM
. 2009.
Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.
.
Biogerontology. 10(4):443-56.
Hagen TM
,
Moreau R
,
Suh JH
,
Visioli F
. 2002.
Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.
.
Ann N Y Acad Sci. 959:491-507.
Pride H
,
Yu Z
,
Sunchu B
,
Mochnick J
,
Coles A
,
Zhang Y
,
Buffenstein R
,
Hornsby PJ
,
Austad SN
,
Perez VI
. 2015.
Long-lived species have improved proteostasis compared to phylogenetically-related shorter-lived species.
.
Biochem Biophys Res Commun. 457(4):669-75.
Ivanov V
,
Carr AC
,
Frei B
. 2001.
Red wine antioxidants bind to human lipoproteins and protect them from metal ion-dependent and -independent oxidation.
.
J Agric Food Chem. 49(9):4442-9.
Yang L
,
Choi J
,
Maier CS
,
Stevens JF
. 2024.
Profiling of Oxylipins as Markers of Oxidative Stress in Biological Samples.
.
Curr Protoc. 4(3):e992.
Matsumoto S
,
Traber MG
,
Leonard SW
,
Choi J
,
Fang X
,
Maishan M
,
Wick KD
,
Jones KD
,
Calfee CS
,
Gotts JE
et al.
. 2022.
Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages.
.
Am J Physiol Lung Cell Mol Physiol. 322(6):L771-L783.
Shay KPetersen
,
Moreau RF
,
Smith EJ
,
Hagen TM
. 2008.
Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.
IUBMB Life. 60(6):362-7.
Traber MG
,
Buettner GR
,
Bruno RS
. 2019.
The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome.
.
Redox Biol. 21:101091.
Traber MG
. 2007.
Heart disease and single-vitamin supplementation.
.
Am J Clin Nutr. 85(1):293S-299S.
Suh JH
,
Shigeno ET
,
Morrow JD
,
Cox B
,
Rocha AE
,
Frei B
,
Hagen TM
. 2001.
Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid.
.
FASEB J. 15(3):700-6.
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