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Traber, Maret G
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Cross-Over Studies
Bruno RS
,
Leonard SW
,
Atkinson J
,
Montine TJ
,
Ramakrishnan R
,
Bray TM
,
Traber MG
. 2006.
Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation.
.
Free Radic Biol Med. 40(4):689-97.
Traber MG
,
Leonard SW
,
Ebenuwa I
,
Violet P-C
,
Wang Y
,
Niyyati M
,
Padayatty S
,
Tu H
,
Courville A
,
Bernstein S
et al.
. 2019.
Vitamin E absorption and kinetics in healthy women, as modulated by food and by fat, studied using 2 deuterium-labeled α-tocopherols in a 3-phase crossover design.
.
Am J Clin Nutr. 110(5):1148-1167.
Bobe G
,
Cobb TJ
,
Leonard SW
,
Aponso S
,
Bahro CB
,
Koley D
,
Mah E
,
Bruno RS
,
Traber MG
. 2017.
Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome.
.
Redox Biol. 12:121-128.
Traber MG
,
Mah E
,
Leonard SW
,
Bobe G
,
Bruno RS
. 2017.
Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial.
.
Am J Clin Nutr. 105(3):571-579.
Cytochrome P-450 CYP2B1
Mustacich DJ
,
Leonard SW
,
Patel NK
,
Traber MG
. 2010.
Alpha-tocopherol beta-oxidation localized to rat liver mitochondria.
.
Free Radic Biol Med. 48(1):73-81.
Cytochrome P-450 CYP3A
Traber MG
,
Siddens LK
,
Leonard SW
,
Schock B
,
Gohil K
,
Krueger SK
,
Cross CE
,
Williams DE
. 2005.
Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.
.
Free Radic Biol Med. 38(6):773-85.
Traber MG
. 2010.
Regulation of xenobiotic metabolism, the only signaling function of alpha-tocopherol?
Mol Nutr Food Res. 54(5):661-8.
Cytochrome P-450 Enzyme System
Mustacich DJ
,
Leonard SW
,
Devereaux MW
,
Sokol RJ
,
Traber MG
. 2006.
Alpha-tocopherol regulation of hepatic cytochrome P450s and ABC transporters in rats.
.
Free Radic Biol Med. 41(7):1069-78.
Farley SM
,
Leonard SW
,
Taylor AW
,
Birringer M
,
Edson KZ
,
Rettie AE
,
Traber MG
. 2013.
ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol.
.
Mol Nutr Food Res. 57(10):1785-93.
Mustacich DJ
,
Vo AT
,
Elias VD
,
Payne K
,
Sullivan L
,
Leonard SW
,
Traber MG
. 2007.
Regulatory mechanisms to control tissue alpha-tocopherol.
.
Free Radic Biol Med. 43(4):610-8.
Traber MG
,
Labut EM
,
Leonard SW
,
Lebold KM
. 2011.
α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes.
.
Free Radic Biol Med. 51(11):2031-40.
Traber MG
. 2010.
Regulation of xenobiotic metabolism, the only signaling function of alpha-tocopherol?
Mol Nutr Food Res. 54(5):661-8.
Traber MG
,
Mustacich DJ
,
Sullivan LC
,
Leonard SW
,
Ahern-Rindell A
,
Kerkvliet N
. 2010.
Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice.
.
J Nutr Biochem. 21(12):1193-9.
Athinarayanan S
,
Wei R
,
Zhang M
,
Bai S
,
Traber MG
,
Yates K
,
Cummings OW
,
Molleston J
,
Liu W
,
Chalasani N
. 2014.
Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological response in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials.
.
PLoS One. 9(4):e95366.
Cytochrome P450 Family 4
Farley SM
,
Leonard SW
,
Taylor AW
,
Birringer M
,
Edson KZ
,
Rettie AE
,
Traber MG
. 2013.
ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol.
.
Mol Nutr Food Res. 57(10):1785-93.
Traber MG
. 2010.
Regulation of xenobiotic metabolism, the only signaling function of alpha-tocopherol?
Mol Nutr Food Res. 54(5):661-8.
Athinarayanan S
,
Wei R
,
Zhang M
,
Bai S
,
Traber MG
,
Yates K
,
Cummings OW
,
Molleston J
,
Liu W
,
Chalasani N
. 2014.
Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological response in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials.
.
PLoS One. 9(4):e95366.
Cytokines
Traber MG
,
Atkinson J
. 2007.
Vitamin E, antioxidant and nothing more.
.
Free Radic Biol Med. 43(1):4-15.
Traber MG
. 2006.
Relationship of vitamin E metabolism and oxidation in exercising human subjects.
.
Br J Nutr. 96 Suppl 1:S34-7.
Cytoprotection
Traber MG
,
Stevens JF
. 2011.
Vitamins C and E: beneficial effects from a mechanistic perspective.
.
Free Radic Biol Med. 51(5):1000-13.
Deuterium
Leonard SW
,
Terasawa Y
,
Farese RV
,
Traber MG
. 2002.
Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice.
.
Am J Clin Nutr. 75(3):555-60.
Traber MG
,
Leonard SW
,
Ebenuwa I
,
Violet P-C
,
Wang Y
,
Niyyati M
,
Padayatty S
,
Tu H
,
Courville A
,
Bernstein S
et al.
. 2019.
Vitamin E absorption and kinetics in healthy women, as modulated by food and by fat, studied using 2 deuterium-labeled α-tocopherols in a 3-phase crossover design.
.
Am J Clin Nutr. 110(5):1148-1167.
Farley SM
,
Leonard SW
,
Stevens JF
,
Traber MG
. 2014.
Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion.
.
Mol Nutr Food Res. 58(8):1610-9.
Mah E
,
Sapper TN
,
Chitchumroonchokchai C
,
Failla ML
,
Schill KE
,
Clinton SK
,
Bobe G
,
Traber MG
,
Bruno RS
. 2015.
α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial.
.
Am J Clin Nutr. 102(5):1070-80.
Leonard SW
,
Bruno RS
,
Ramakrishnan R
,
Bray T
,
Traber MG
. 2004.
Cigarette smoking increases human vitamin E requirements as estimated by plasma deuterium-labeled CEHC.
.
Ann N Y Acad Sci. 1031:357-60.
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