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Faculty and Staff
Our Research
Micronutrient Information
Publications
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Biblio
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Hagen, Tory M
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Mitochondria
Moreau R
,
Heath S-HD
,
Doneanu CE
,
Harris RA
,
Hagen TM
. 2004.
Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart.
.
Biochem Biophys Res Commun. 325(1):48-58.
Hagen TM
,
Moreau R
,
Suh JH
,
Visioli F
. 2002.
Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.
.
Ann N Y Acad Sci. 959:491-507.
Gómez LA
,
Heath S-HD
,
Hagen TM
. 2012.
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.
.
Mech Ageing Dev. 133(2-3):99-106.
Mitochondria, Heart
Suh JH
,
Heath S-H
,
Hagen TM
. 2003.
Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress.
.
Free Radic Biol Med. 35(9):1064-72.
Moreau R
,
Nguyen BT
,
Doneanu CE
,
Hagen TM
. 2005.
Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats.
.
Biochem Pharmacol. 69(1):29-40.
Monette JS
,
Gómez LA
,
Moreau RF
,
Bemer BA
,
Taylor AW
,
Hagen TM
. 2010.
Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations.
.
Biochem Biophys Res Commun. 398(2):272-7.
Gómez LA
,
Heath S-HD
,
Hagen TM
. 2012.
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.
.
Mech Ageing Dev. 133(2-3):99-106.
Moreau R
,
Heath S-HD
,
Doneanu CE
,
J Lindsay G
,
Hagen TM
. 2003.
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
.
Antioxid Redox Signal. 5(5):517-27.
Mitophagy
Visioli F
,
Ingram A
,
Beckman JS
,
Magnusson KR
,
Hagen TM
. 2022.
Strategies to protect against age-related mitochondrial decay: Do natural products and their derivatives help?
Free Radic Biol Med. 178:330-346.
Models, Animal
Finlay LA
,
Michels AJ
,
Butler JA
,
Smith EJ
,
Monette JS
,
Moreau RF
,
Petersen SKate
,
Frei B
,
Hagen TM
. 2012.
R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.
.
Am J Physiol Regul Integr Comp Physiol. 302(5):R587-97.
Models, Biological
Shay KPetersen
,
Moreau RF
,
Smith EJ
,
Smith AR
,
Hagen TM
. 2009.
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
.
Biochim Biophys Acta. 1790(10):1149-60.
Gómez LA
,
Heath S-HD
,
Hagen TM
. 2012.
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.
.
Mech Ageing Dev. 133(2-3):99-106.
Smith AR
,
Visioli F
,
Hagen TM
. 2002.
Vitamin C matters: increased oxidative stress in cultured human aortic endothelial cells without supplemental ascorbic acid.
.
FASEB J. 16(9):1102-4.
Models, Chemical
Shay KPetersen
,
Moreau RF
,
Smith EJ
,
Hagen TM
. 2008.
Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.
IUBMB Life. 60(6):362-7.
Molecular Sequence Data
Moreau R
,
Nguyen BT
,
Doneanu CE
,
Hagen TM
. 2005.
Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats.
.
Biochem Pharmacol. 69(1):29-40.
Moreau R
,
Heath S-HD
,
Doneanu CE
,
J Lindsay G
,
Hagen TM
. 2003.
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
.
Antioxid Redox Signal. 5(5):517-27.
Moreau R
,
Heath S-HD
,
Doneanu CE
,
Harris RA
,
Hagen TM
. 2004.
Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart.
.
Biochem Biophys Res Commun. 325(1):48-58.
Shenvi SV
,
Smith EJ
,
Hagen TM
. 2009.
Transcriptional regulation of rat gamma-glutamate cysteine ligase catalytic subunit gene is mediated through a distal antioxidant response element.
.
Pharmacol Res. 60(4):229-36.
Molecular Structure
Shay KPetersen
,
Moreau RF
,
Smith EJ
,
Smith AR
,
Hagen TM
. 2009.
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
.
Biochim Biophys Acta. 1790(10):1149-60.
Molecular Weight
Suh JH
,
Heath S-H
,
Hagen TM
. 2003.
Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress.
.
Free Radic Biol Med. 35(9):1064-72.
Myocardium
Gómez LA
,
Heath S-HD
,
Hagen TM
. 2012.
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.
.
Mech Ageing Dev. 133(2-3):99-106.
Hagen TM
,
Moreau R
,
Suh JH
,
Visioli F
. 2002.
Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.
.
Ann N Y Acad Sci. 959:491-507.
Moreau R
,
Heath S-HD
,
Doneanu CE
,
J Lindsay G
,
Hagen TM
. 2003.
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
.
Antioxid Redox Signal. 5(5):517-27.
Moreau R
,
Heath S-HD
,
Doneanu CE
,
Harris RA
,
Hagen TM
. 2004.
Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart.
.
Biochem Biophys Res Commun. 325(1):48-58.
Suh JH
,
Heath S-H
,
Hagen TM
. 2003.
Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress.
.
Free Radic Biol Med. 35(9):1064-72.
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