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Faculty and Staff
Our Research
Micronutrient Information
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Biblio
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Stevens, Jan F
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Kinetics
Yang L
,
Broderick D
,
Campbell Y
,
Gombart AF
,
Stevens JF
,
Jiang Y
,
Hsu VL
,
Bisson WH
,
Maier CS
. 2016.
Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies.
.
Biochim Biophys Acta. 1864(12):1667-1677.
Kidney
Farley SM
,
Leonard SW
,
Stevens JF
,
Traber MG
. 2014.
Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion.
.
Mol Nutr Food Res. 58(8):1610-9.
Isotope Labeling
Axton ER
,
Hardardt EA
,
Stevens JF
. 2016.
Stable isotope-assisted LC-MS/MS monitoring of glyceryl trinitrate bioactivation in a cell culture model of nitrate tolerance.
.
J Chromatogr B Analyt Technol Biomed Life Sci. 1019:156-63.
Kesinger NG
,
Langsdorf BL
,
Yokochi AF
,
Miranda CL
,
Stevens JF
. 2010.
Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal.
.
Chem Res Toxicol. 23(4):836-44.
Isothiocyanates
Bouranis JA
,
Beaver LM
,
Wong CP
,
Choi J
,
Hamer S
,
Davis EW
,
Brown KS
,
Jiang D
,
Sharpton TJ
,
Stevens JF
et al.
. 2024.
Sulforaphane and Sulforaphane-Nitrile Metabolism in Humans Following Broccoli Sprout Consumption: Inter-individual Variation, Association with Gut Microbiome Composition, and Differential Bioactivity.
.
Mol Nutr Food Res. 68(4):e2300286.
Bouranis JA
,
Beaver LM
,
Choi J
,
Wong CP
,
Jiang D
,
Sharpton TJ
,
Stevens JF
,
Ho E
. 2021.
Composition of the Gut Microbiome Influences Production of Sulforaphane-Nitrile and Iberin-Nitrile from Glucosinolates in Broccoli Sprouts.
.
Nutrients. 13(9)
Isomerism
Ellinwood DC
,
El-Mansy MF
,
Plagmann LS
,
Stevens JF
,
Maier CS
,
Gombart AF
,
Blakemore PR
. 2017.
Total synthesis of [ C] -, [ C] -, and [ C] -isotopomers of xanthohumol, the principal prenylflavonoid from hops.
.
J Labelled Comp Radiopharm. 60(14):639-648.
Isoflavones
Stevens JF
,
Page JE
. 2004.
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
.
Phytochemistry. 65(10):1317-30.
Ion Channels
Kirkwood JS
,
Legette LCL
,
Miranda CL
,
Jiang Y
,
Stevens JF
. 2013.
A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.
.
J Biol Chem. 288(26):19000-13.
Interleukin-6
Miranda CL
,
Elias VD
,
Hay JJ
,
Choi J
,
Reed RL
,
Stevens JF
. 2016.
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
.
Arch Biochem Biophys. 599:22-30.
Insulin Resistance
Johnson LA
,
Torres ERuth S
,
Impey S
,
Stevens JF
,
Raber J
. 2017.
Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome.
.
Sci Rep. 7:43701.
Insulin
Miranda CL
,
Elias VD
,
Hay JJ
,
Choi J
,
Reed RL
,
Stevens JF
. 2016.
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
.
Arch Biochem Biophys. 599:22-30.
Injections, Subcutaneous
Farley SM
,
Leonard SW
,
Stevens JF
,
Traber MG
. 2014.
Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion.
.
Mol Nutr Food Res. 58(8):1610-9.
Injections, Intravenous
Legette LC
,
Ma L
,
Reed RL
,
Miranda CL
,
Christensen JMark
,
Rodriguez-Proteau R
,
Stevens JF
. 2012.
Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.
.
Mol Nutr Food Res. 56(3):466-74.
Inflammation
Sowell J
,
Frei B
,
Stevens JF
. 2004.
Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma.
.
Proc Natl Acad Sci U S A. 101(52):17964-9.
Traber MG
,
Stevens JF
. 2011.
Vitamins C and E: beneficial effects from a mechanistic perspective.
.
Free Radic Biol Med. 51(5):1000-13.
Langley BO
,
Ryan JJoan
,
Phipps J
,
Buttolph L
,
Bray B
,
Aslan JE
,
Metz TO
,
Stevens JF
,
Bradley R
. 2022.
Xanthohumol microbiome and signature in adults with Crohn's disease (the XMaS trial): a protocol for a phase II triple-masked, placebo-controlled clinical trial.
.
Trials. 23(1):885.
Inactivation, Metabolic
Miranda CL
,
Reed RL
,
Kuiper HC
,
Alber S
,
Stevens JF
. 2009.
Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells.
.
Chem Res Toxicol. 22(5):863-74.
Hypoxia-Inducible Factor 1
Traber MG
,
Stevens JF
. 2011.
Vitamins C and E: beneficial effects from a mechanistic perspective.
.
Free Radic Biol Med. 51(5):1000-13.
Hypoglycemic Agents
Legette LC
,
Karnpracha C
,
Reed RL
,
Choi J
,
Bobe G
,
J Christensen M
,
Rodriguez-Proteau R
,
Purnell JQ
,
Stevens JF
. 2014.
Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops.
.
Mol Nutr Food Res. 58(2):248-55.
Hydrolysis
Kubglomsong S
,
Theerakulkait C
,
Reed RL
,
Yang L
,
Maier CS
,
Stevens JF
. 2018.
Isolation and Identification of Tyrosinase-Inhibitory and Copper-Chelating Peptides from Hydrolyzed Rice-Bran-Derived Albumin.
.
J Agric Food Chem. 66(31):8346-8354.
Wattanasiritham L
,
Theerakulkait C
,
Wickramasekara S
,
Maier CS
,
Stevens JF
. 2016.
Isolation and identification of antioxidant peptides from enzymatically hydrolyzed rice bran protein.
.
Food Chem. 192:156-62.
Hydrazines
Han B
,
Stevens JF
,
Maier CS
. 2007.
Design, synthesis, and application of a hydrazide-functionalized isotope-coded affinity tag for the quantification of oxylipid-protein conjugates.
.
Anal Chem. 79(9):3342-54.
Humulus
Lela L
,
Ponticelli M
,
Carlucci V
,
Stevens JF
,
Faraone I
,
Tzvetkov NT
,
Milella L
. 2024.
Insight into the Interaction of L. Specialized Metabolites and Gastrointestinal Bitter Taste Receptors: Study in STC-1 Cells and Molecular Docking.
.
J Nat Prod. 87(8):2021-2033.
Stevens JF
,
Page JE
. 2004.
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
.
Phytochemistry. 65(10):1317-30.
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