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About the LPI
Faculty and Staff
Our Research
Micronutrient Information
Publications
Contact Information
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Biblio
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Glutathione
Visioli F
,
Smith A
,
Zhang W
,
Keaney JF
,
Hagen T
,
Frei B
. 2002.
Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status.
.
Redox Rep. 7(4):223-7.
Li C
,
Zhang W-J
,
Choi J
,
Frei B
. 2016.
Quercetin affects glutathione levels and redox ratio in human aortic endothelial cells not through oxidation but formation and cellular export of quercetin-glutathione conjugates and upregulation of glutamate-cysteine ligase.
.
Redox Biol. 9:220-228.
Sowell J
,
Frei B
,
Stevens JF
. 2004.
Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma.
.
Proc Natl Acad Sci U S A. 101(52):17964-9.
Glycoside Hydrolase Inhibitors
Yilmazer-Musa M
,
Griffith AM
,
Michels AJ
,
Schneider E
,
Frei B
. 2012.
Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity.
.
J Agric Food Chem. 60(36):8924-9.
Health
Higdon JV
,
Frei B
. 2006.
Coffee and health: a review of recent human research.
.
Crit Rev Food Sci Nutr. 46(2):101-23.
Health Promotion
Frei B
,
Birlouez-Aragon I
,
Lykkesfeldt J
. 2012.
Authors' perspective: What is the optimum intake of vitamin C in humans?
Crit Rev Food Sci Nutr. 52(9):815-29.
Higdon JV
,
Frei B
. 2006.
Coffee and health: a review of recent human research.
.
Crit Rev Food Sci Nutr. 46(2):101-23.
Heme
Li L
,
Frei B
. 2009.
Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamine.
.
Arterioscler Thromb Vasc Biol. 29(5):732-8.
Heme Oxygenase-1
Li C
,
Zhang W-J
,
Frei B
. 2016.
Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction.
.
Redox Biol. 9:104-113.
Hepatitis
Finlay LA
,
Michels AJ
,
Butler JA
,
Smith EJ
,
Monette JS
,
Moreau RF
,
Petersen SKate
,
Frei B
,
Hagen TM
. 2012.
R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.
.
Am J Physiol Regul Integr Comp Physiol. 302(5):R587-97.
Hepatocytes
Lotito SB
,
Frei B
. 2006.
Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism.
.
J Biol Chem. 281(48):37102-10.
Hip Fractures
Higdon JV
,
Frei B
. 2006.
Coffee and health: a review of recent human research.
.
Crit Rev Food Sci Nutr. 46(2):101-23.
Histidine
Zhu B-Z
,
Antholine WE
,
Frei B
. 2002.
Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex.
.
Free Radic Biol Med. 32(12):1333-8.
Homeostasis
Michels AJ
,
Hagen TM
,
Frei B
. 2013.
Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.
.
Annu Rev Nutr. 33:45-70.
Humans
Blumberg JB
,
Frei B
,
Fulgoni VL
,
Weaver CM
,
Zeisel SH
. 2017.
Contribution of Dietary Supplements to Nutritional Adequacy in Race/Ethnic Population Subgroups in the United States.
.
Nutrients. 9(12)
Carr AC
,
Frei B
. 2002.
Human neutrophils oxidize low-density lipoprotein by a hypochlorous acid-dependent mechanism: the role of vitamin C.
.
Biol Chem. 383(3-4):627-36.
Lotito SB
,
Frei B
. 2004.
The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids.
.
Free Radic Biol Med. 37(2):251-8.
Frei B
,
Lawson S
. 2008.
Vitamin C and cancer revisited.
.
Proc Natl Acad Sci U S A. 105(32):11037-8.
Blumberg JB
,
Frei B
,
Fulgoni VL
,
Weaver CM
,
Zeisel SH
. 2017.
Contribution of Dietary Supplements to Nutritional Adequacy by Socioeconomic Subgroups in Adults of the United States.
.
Nutrients. 10(1)
Yilmazer-Musa M
,
Griffith AM
,
Michels AJ
,
Schneider E
,
Frei B
. 2012.
Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity.
.
J Agric Food Chem. 60(36):8924-9.
Kerr DCR
,
Zava DT
,
Piper WT
,
Saturn SR
,
Frei B
,
Gombart AF
. 2015.
Associations between vitamin D levels and depressive symptoms in healthy young adult women.
.
Psychiatry Res. 227(1):46-51.
Michels AJ
,
Hagen TM
,
Frei B
. 2013.
Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.
.
Annu Rev Nutr. 33:45-70.
Frei B
,
Birlouez-Aragon I
,
Lykkesfeldt J
. 2012.
Authors' perspective: What is the optimum intake of vitamin C in humans?
Crit Rev Food Sci Nutr. 52(9):815-29.
Zhang WJian
,
Frei B
. 2003.
Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells.
.
Free Radic Biol Med. 34(6):674-82.
Sowell J
,
Frei B
,
Stevens JF
. 2004.
Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma.
.
Proc Natl Acad Sci U S A. 101(52):17964-9.
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