Found 467 results
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Filters: Author is Hagen, Tory M  [Clear All Filters]
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Antimycin A
Suh JH, Heath S-H, Hagen TM.  2003.  Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress.. Free Radic Biol Med. 35(9):1064-72.
Animals, Newborn
Robinson KM, Janes MS, Pehar M, Monette JS, Ross MF, Hagen TM, Murphy MP, Beckman JS.  2006.  Selective fluorescent imaging of superoxide in vivo using ethidium-based probes.. Proc Natl Acad Sci U S A. 103(41):15038-43.
Animals
Michels AJ, Hagen TM, Frei B.  2013.  Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.. Annu Rev Nutr. 33:45-70.
Shay KPetersen, Moreau RF, Smith EJ, Hagen TM.  2008.  Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life. 60(6):362-7.
Smith EJ, Shay KP, Thomas NO, Butler JA, Finlay LF, Hagen TM.  2015.  Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a.. Free Radic Biol Med. 89:1184-91.
Zhang W-J, Bird KE, McMillen TS, Leboeuf RC, Hagen TM, Frei B.  2008.  Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice.. Circulation. 117(3):421-8.
Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SKate, Frei B, Hagen TM.  2012.  R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.. Am J Physiol Regul Integr Comp Physiol. 302(5):R587-97.
Gómez LA, Hagen TM.  2012.  Age-related decline in mitochondrial bioenergetics: does supercomplex destabilization determine lower oxidative capacity and higher superoxide production? Semin Cell Dev Biol. 23(7):758-67.
Thomas NO, Shay KP, Kelley AR, Butler JA, Hagen TM.  2016.  Glutathione maintenance mitigates age-related susceptibility to redox cycling agents.. Redox Biol. 10:45-52.
Li L, Smith A, Hagen TM, Frei B.  2010.  Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.. Ann N Y Acad Sci. 1203:151-9.
Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN.  2002.  Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.. Proc Natl Acad Sci U S A. 99(4):1870-5.
Moreau R, Heath S-HD, Doneanu CE, Harris RA, Hagen TM.  2004.  Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart.. Biochem Biophys Res Commun. 325(1):48-58.
Monette JS, Gómez LA, Moreau RF, Bemer BA, Taylor AW, Hagen TM.  2010.  Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations.. Biochem Biophys Res Commun. 398(2):272-7.
Hagen TM, Moreau R, Suh JH, Visioli F.  2002.  Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.. Ann N Y Acad Sci. 959:491-507.
Dixon BM, Heath S-HD, Kim R, Suh JH, Hagen TM.  2008.  Assessment of endoplasmic reticulum glutathione redox status is confounded by extensive ex vivo oxidation.. Antioxid Redox Signal. 10(5):963-72.
Suh JH, Moreau R, Heath S-HD, Hagen TM.  2005.  Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.. Redox Rep. 10(1):52-60.
Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu R-M, Hagen TM.  2004.  Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.. Proc Natl Acad Sci U S A. 101(10):3381-6.
Gómez LA, Heath S-HD, Hagen TM.  2012.  Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.. Mech Ageing Dev. 133(2-3):99-106.
Visioli F, Ingram A, Beckman JS, Magnusson KR, Hagen TM.  2022.  Strategies to protect against age-related mitochondrial decay: Do natural products and their derivatives help? Free Radic Biol Med. 178:330-346.
Shenvi SV, Smith EJ, Hagen TM.  2009.  Transcriptional regulation of rat gamma-glutamate cysteine ligase catalytic subunit gene is mediated through a distal antioxidant response element.. Pharmacol Res. 60(4):229-36.
Smith AR, Visioli F, Hagen TM.  2006.  Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age.. Arch Biochem Biophys. 454(1):100-5.
Butler JA, Hagen TM, Moreau R.  2009.  Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion.. Arch Biochem Biophys. 485(1):63-71.
Moreau R, Heath S-HD, Doneanu CE, J Lindsay G, Hagen TM.  2003.  Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.. Antioxid Redox Signal. 5(5):517-27.
Robinson KM, Janes MS, Pehar M, Monette JS, Ross MF, Hagen TM, Murphy MP, Beckman JS.  2006.  Selective fluorescent imaging of superoxide in vivo using ethidium-based probes.. Proc Natl Acad Sci U S A. 103(41):15038-43.
Shay KPetersen, Moreau RF, Smith EJ, Smith AR, Hagen TM.  2009.  Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.. Biochim Biophys Acta. 1790(10):1149-60.

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