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Faculty and Staff
Our Research
Micronutrient Information
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Biblio
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Dashwood, Roderick H
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Histone Deacetylases
Rajendran P
,
Kidane AI
,
Yu T-W
,
Dashwood W-M
,
Bisson WH
,
Löhr CV
,
Ho E
,
Williams DE
,
Dashwood RH
. 2013.
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.
.
Epigenetics. 8(6):612-23.
Watson GW
,
Wickramasekara S
,
Fang Y
,
Maier CS
,
Williams DE
,
Dashwood RH
,
Perez VI
,
Ho E
. 2016.
HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells.
.
Exp Biol Med (Maywood). 241(11):1177-85.
Myzak MC
,
P Karplus A
,
Chung F-L
,
Dashwood RH
. 2004.
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.
.
Cancer Res. 64(16):5767-74.
Histone Deacetylase Inhibitors
Myzak MC
,
Dashwood RH
. 2006.
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane.
.
Curr Drug Targets. 7(4):443-52.
Myzak MC
,
Hardin K
,
Wang R
,
Dashwood RH
,
Ho E
. 2006.
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells.
.
Carcinogenesis. 27(4):811-9.
Myzak MC
,
Ho E
,
Dashwood RH
. 2006.
Dietary agents as histone deacetylase inhibitors.
.
Mol Carcinog. 45(6):443-6.
Rajendran P
,
Williams DE
,
Ho E
,
Dashwood RH
. 2011.
Metabolism as a key to histone deacetylase inhibition.
.
Crit Rev Biochem Mol Biol. 46(3):181-99.
Myzak MC
,
W Dashwood M
,
Orner GA
,
Ho E
,
Dashwood RH
. 2006.
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice.
.
FASEB J. 20(3):506-8.
Dashwood RH
,
Ho E
. 2008.
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates.
.
Nutr Rev. 66 Suppl 1:S36-8.
Nian H
,
Delage B
,
Ho E
,
Dashwood RH
. 2009.
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds.
.
Environ Mol Mutagen. 50(3):213-21.
Myzak MC
,
P Karplus A
,
Chung F-L
,
Dashwood RH
. 2004.
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.
.
Cancer Res. 64(16):5767-74.
Dashwood RH
. 2006.
Xenobiotic metabolism relevance to cancer.
.
J Nutr. 136(10):2681S-2S.
Nian H
,
Delage B
,
Pinto JT
,
Dashwood RH
. 2008.
Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter.
.
Carcinogenesis. 29(9):1816-24.
Rajendran P
,
Kidane AI
,
Yu T-W
,
Dashwood W-M
,
Bisson WH
,
Löhr CV
,
Ho E
,
Williams DE
,
Dashwood RH
. 2013.
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.
.
Epigenetics. 8(6):612-23.
Beaver LM
,
Yu T-W
,
Sokolowski EI
,
Williams DE
,
Dashwood RH
,
Ho E
. 2012.
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells.
.
Toxicol Appl Pharmacol. 263(3):345-51.
Myzak MC
,
Tong P
,
Dashwood W-M
,
Dashwood RH
,
Ho E
. 2007.
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.
.
Exp Biol Med (Maywood). 232(2):227-34.
Histone Deacetylase 6
Watson GW
,
Wickramasekara S
,
Fang Y
,
Maier CS
,
Williams DE
,
Dashwood RH
,
Perez VI
,
Ho E
. 2016.
HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells.
.
Exp Biol Med (Maywood). 241(11):1177-85.
Histone Deacetylase 2
Beaver LM
,
Yu T-W
,
Sokolowski EI
,
Williams DE
,
Dashwood RH
,
Ho E
. 2012.
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells.
.
Toxicol Appl Pharmacol. 263(3):345-51.
Histone Deacetylase 1
Myzak MC
,
P Karplus A
,
Chung F-L
,
Dashwood RH
. 2004.
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.
.
Cancer Res. 64(16):5767-74.
Nian H
,
Delage B
,
Pinto JT
,
Dashwood RH
. 2008.
Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter.
.
Carcinogenesis. 29(9):1816-24.
Heterocyclic Compounds
Dashwood RH
. 2002.
Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models.
.
Mutat Res. 511(2):89-112.
Dashwood RH
. 2003.
Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis.
.
J Biochem Mol Biol. 36(1):35-42.
Hepatocyte Growth Factor
Larsen CA
,
Dashwood RH
. 2010.
(-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells.
.
Arch Biochem Biophys. 501(1):52-7.
Health
Dashwood RH
. 2007.
Frontiers in polyphenols and cancer prevention.
.
J Nutr. 137(1 Suppl):267S-269S.
HCT116 Cells
Myzak MC
,
P Karplus A
,
Chung F-L
,
Dashwood RH
. 2004.
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.
.
Cancer Res. 64(16):5767-74.
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