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Faculty and Staff
Our Research
Micronutrient Information
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Biblio
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Miranda, Cristobal L
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Chromatography, High Pressure Liquid
Kesinger NG
,
Langsdorf BL
,
Yokochi AF
,
Miranda CL
,
Stevens JF
. 2010.
Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal.
.
Chem Res Toxicol. 23(4):836-44.
Chromatography, Liquid
Kirkwood JS
,
Legette LCL
,
Miranda CL
,
Jiang Y
,
Stevens JF
. 2013.
A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.
.
J Biol Chem. 288(26):19000-13.
Kuiper HC
,
Miranda CL
,
Sowell JD
,
Stevens JF
. 2008.
Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress.
.
J Biol Chem. 283(25):17131-8.
Legette LC
,
Ma L
,
Reed RL
,
Miranda CL
,
Christensen JMark
,
Rodriguez-Proteau R
,
Stevens JF
. 2012.
Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.
.
Mol Nutr Food Res. 56(3):466-74.
Cognition
Kundu P
,
Paraiso IL
,
Choi J
,
Miranda CL
,
Kioussi C
,
Maier CS
,
Bobe G
,
Stevens JF
,
Raber J
. 2022.
Xanthohumol improves cognition in farnesoid X receptor-deficient mice on a high-fat diet.
.
Dis Model Mech. 15(11)
Cytidine Diphosphate Choline
Kirkwood JS
,
Miranda CL
,
Bobe G
,
Maier CS
,
Stevens JF
. 2016.
18O-Tracer Metabolomics Reveals Protein Turnover and CDP-Choline Cycle Activity in Differentiating 3T3-L1 Pre-Adipocytes.
.
PLoS One. 11(6):e0157118.
Diet, High-Fat
Kundu P
,
Paraiso IL
,
Choi J
,
Miranda CL
,
Kioussi C
,
Maier CS
,
Bobe G
,
Stevens JF
,
Raber J
. 2022.
Xanthohumol improves cognition in farnesoid X receptor-deficient mice on a high-fat diet.
.
Dis Model Mech. 15(11)
Logan IE
,
Shulzhenko N
,
Sharpton TJ
,
Bobe G
,
Liu K
,
Nuss S
,
Jones ML
,
Miranda CL
,
Vasquez-Perez S
,
Pennington JM
et al.
. 2021.
Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice.
.
Mol Nutr Food Res. 65(21):e2100389.
Dietary Fats
Miranda CL
,
Elias VD
,
Hay JJ
,
Choi J
,
Reed RL
,
Stevens JF
. 2016.
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
.
Arch Biochem Biophys. 599:22-30.
Diglycerides
Kundu P
,
Paraiso IL
,
Choi J
,
Miranda CL
,
Kioussi C
,
Maier CS
,
Bobe G
,
Stevens JF
,
Raber J
. 2022.
Xanthohumol improves cognition in farnesoid X receptor-deficient mice on a high-fat diet.
.
Dis Model Mech. 15(11)
Disease Models, Animal
Kirkwood JS
,
Legette LCL
,
Miranda CL
,
Jiang Y
,
Stevens JF
. 2013.
A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.
.
J Biol Chem. 288(26):19000-13.
Dose-Response Relationship, Drug
Legette LC
,
Ma L
,
Reed RL
,
Miranda CL
,
Christensen JMark
,
Rodriguez-Proteau R
,
Stevens JF
. 2012.
Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.
.
Mol Nutr Food Res. 56(3):466-74.
Legette LCL
,
Luna AYMoreno
,
Reed RL
,
Miranda CL
,
Bobe G
,
Proteau RR
,
Stevens JF
. 2013.
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
.
Phytochemistry. 91:236-41.
Dyslipidemias
Legette LC
,
Ma L
,
Reed RL
,
Miranda CL
,
Christensen JMark
,
Rodriguez-Proteau R
,
Stevens JF
. 2012.
Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.
.
Mol Nutr Food Res. 56(3):466-74.
Eating
Legette LCL
,
Luna AYMoreno
,
Reed RL
,
Miranda CL
,
Bobe G
,
Proteau RR
,
Stevens JF
. 2013.
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
.
Phytochemistry. 91:236-41.
Energy Metabolism
Kirkwood JS
,
Lebold KM
,
Miranda CL
,
Wright CL
,
Miller GW
,
Tanguay RL
,
Barton CL
,
Traber MG
,
Stevens JF
. 2012.
Vitamin C deficiency activates the purine nucleotide cycle in zebrafish.
.
J Biol Chem. 287(6):3833-41.
Fasting
Legette LCL
,
Luna AYMoreno
,
Reed RL
,
Miranda CL
,
Bobe G
,
Proteau RR
,
Stevens JF
. 2013.
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
.
Phytochemistry. 91:236-41.
Female
Kuiper HC
,
Langsdorf BL
,
Miranda CL
,
Joss J
,
Jubert C
,
Mata JE
,
Stevens JF
. 2010.
Quantitation of mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in a smoking cessation study.
.
Free Radic Biol Med. 48(1):65-72.
Kirkwood JS
,
Legette LCL
,
Miranda CL
,
Jiang Y
,
Stevens JF
. 2013.
A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.
.
J Biol Chem. 288(26):19000-13.
Legette LCL
,
Luna AYMoreno
,
Reed RL
,
Miranda CL
,
Bobe G
,
Proteau RR
,
Stevens JF
. 2013.
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
.
Phytochemistry. 91:236-41.
Flavonoids
Kirkwood JS
,
Legette LCL
,
Miranda CL
,
Jiang Y
,
Stevens JF
. 2013.
A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.
.
J Biol Chem. 288(26):19000-13.
Legette LC
,
Ma L
,
Reed RL
,
Miranda CL
,
Christensen JMark
,
Rodriguez-Proteau R
,
Stevens JF
. 2012.
Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.
.
Mol Nutr Food Res. 56(3):466-74.
Miranda CL
,
Elias VD
,
Hay JJ
,
Choi J
,
Reed RL
,
Stevens JF
. 2016.
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
.
Arch Biochem Biophys. 599:22-30.
Peluso MR
,
Miranda CL
,
Hobbs DJ
,
Proteau RR
,
Stevens JFrederik
. 2010.
Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2).
.
Planta Med. 76(14):1536-43.
Logan IE
,
Shulzhenko N
,
Sharpton TJ
,
Bobe G
,
Liu K
,
Nuss S
,
Jones ML
,
Miranda CL
,
Vasquez-Perez S
,
Pennington JM
et al.
. 2021.
Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice.
.
Mol Nutr Food Res. 65(21):e2100389.
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