Linus Pauling Institute

Legette LC, Karnpracha C, Reed RL, Choi J, Bobe G, J Christensen M, Rodriguez-Proteau R, Purnell JQ, Stevens JF.  2014.  Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops.. Mol Nutr Food Res. 58(2):248-55.

Ellinwood DC, El-Mansy MF, Plagmann LS, Stevens JF, Maier CS, Gombart AF, Blakemore PR.  2017.  Total synthesis of [ C] -, [ C] -, and [ C] -isotopomers of xanthohumol, the principal prenylflavonoid from hops.. J Labelled Comp Radiopharm. 60(14):639-648.

Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF.  2016.  Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.. Arch Biochem Biophys. 599:22-30.

Rajendran P, Williams DE, Ho E, Dashwood RH.  2011.  Metabolism as a key to histone deacetylase inhibition.. Crit Rev Biochem Mol Biol. 46(3):181-99.

Lotito SB, Frei B.  2004.  The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids.. Free Radic Biol Med. 37(2):251-8.

Yang L, Broderick D, Campbell Y, Gombart AF, Stevens JF, Jiang Y, Hsu VL, Bisson WH, Maier CS.  2016.  Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies.. Biochim Biophys Acta. 1864(12):1667-1677.

Ivanov V, Carr AC, Frei B.  2001.  Red wine antioxidants bind to human lipoproteins and protect them from metal ion-dependent and -independent oxidation.. J Agric Food Chem. 49(9):4442-9.

Zamzow DR, Elias V, Legette LCL, Choi J, J Stevens F, Magnusson KR.  2014.  Xanthohumol improved cognitive flexibility in young mice.. Behav Brain Res. 275:1-10.

Lela L, Ponticelli M, Carlucci V, Stevens JF, Faraone I, Tzvetkov NT, Milella L.  2024.  Insight into the Interaction of L. Specialized Metabolites and Gastrointestinal Bitter Taste Receptors: Study in STC-1 Cells and Molecular Docking.. J Nat Prod. 87(8):2021-2033.

Legette LC, Ma L, Reed RL, Miranda CL, Christensen JMark, Rodriguez-Proteau R, Stevens JF.  2012.  Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.. Mol Nutr Food Res. 56(3):466-74.

Logan IE, Shulzhenko N, Sharpton TJ, Bobe G, Liu K, Nuss S, Jones ML, Miranda CL, Vasquez-Perez S, Pennington JM et al..  2021.  Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice.. Mol Nutr Food Res. 65(21):e2100389.

Peluso MR, Miranda CL, Hobbs DJ, Proteau RR, Stevens JFrederik.  2010.  Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2).. Planta Med. 76(14):1536-43.

Legette LCL, Luna AYMoreno, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF.  2013.  Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.. Phytochemistry. 91:236-41.

Lotito SB, Frei B.  2006.  Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med. 41(12):1727-46.

Kirkwood JS, Maier C, Stevens JF.  2013.  Simultaneous, untargeted metabolic profiling of polar and nonpolar metabolites by LC-Q-TOF mass spectrometry.. Curr Protoc Toxicol. Chapter 4:Unit4.39.

Larsen CA, Bisson WH, Dashwood RH.  2009.  Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.. J Med Chem. 52(21):6543-5.

Stevens JF, Page JE.  2004.  Xanthohumol and related prenylflavonoids from hops and beer: to your good health!. Phytochemistry. 65(10):1317-30.

Lotito SB, Zhang W-J, Yang CS, Crozier A, Frei B.  2011.  Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties.. Free Radic Biol Med. 51(2):454-63.

Jamieson PE, Smart EB, Bouranis JA, Choi J, Danczak RE, Wong CP, Paraiso IL, Maier CS, Ho E, Sharpton TJ et al..  2024.  Gut enterotype-dependent modulation of gut microbiota and their metabolism in response to xanthohumol supplementation in healthy adults.. Gut Microbes. 16(1):2315633.

Kirkwood JS, Legette LCL, Miranda CL, Jiang Y, Stevens JF.  2013.  A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.. J Biol Chem. 288(26):19000-13.

Kesinger NG, Stevens JF.  2009.  Covalent interaction of ascorbic acid with natural products.. Phytochemistry. 70(17-18):1930-9.

Lotito SB, Frei B.  2004.  Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects.. Free Radic Biol Med. 36(2):201-11.

Zheljazkov VD, Semerdjieva IB, Borisova D, Yankova-Tsvetkova E, Koleva-Valkova LH, Petrova G, Dincheva I, Stevens F, Wu W, Astatkie T et al..  2023.  Phytochemical and biological investigations on Centranthus kellereri (Stoj., Stef. & T. Georgiev) Stoj. & Stef. and C. ruber (L.) DC. and their potential as new medicinal and ornamental plants.. PLoS One. 18(11):e0293877.

Lotito SB, Frei B.  2006.  Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism.. J Biol Chem. 281(48):37102-10.

Higdon JV, Frei B.  2003.  Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions.. Crit Rev Food Sci Nutr. 43(1):89-143.