Linus Pauling Institute

Michels AJ, Frei B.  2013.  Myths, artifacts, and fatal flaws: identifying limitations and opportunities in vitamin C research.. Nutrients. 5(12):5161-92.

Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SKate, Frei B, Hagen TM.  2012.  R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.. Am J Physiol Regul Integr Comp Physiol. 302(5):R587-97.

Wei H, Frei B, Beckman JS, Zhang W-J.  2011.  Copper chelation by tetrathiomolybdate inhibits lipopolysaccharide-induced inflammatory responses in vivo.. Am J Physiol Heart Circ Physiol. 301(3):H712-20.

Li L, Frei B.  2006.  Iron chelation inhibits NF-kappaB-mediated adhesion molecule expression by inhibiting p22(phox) protein expression and NADPH oxidase activity.. Arterioscler Thromb Vasc Biol. 26(12):2638-43.

Zhang W-J, Wei H, Tien Y-T, Frei B.  2011.  Genetic ablation of phagocytic NADPH oxidase in mice limits TNFα-induced inflammation in the lungs but not other tissues.. Free Radic Biol Med. 50(11):1517-25.

Zhang W-J, Wei H, Frei B.  2009.  Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo.. Free Radic Biol Med. 46(6):791-8.

Smith AR, Visioli F, Frei B, Hagen TM.  2006.  Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.. Aging Cell. 5(5):391-400.

Frei B, Lawson S.  2008.  Vitamin C and cancer revisited.. Proc Natl Acad Sci U S A. 105(32):11037-8.

Michels AJ, Hagen TM, Frei B.  2013.  Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.. Annu Rev Nutr. 33:45-70.

Frei B, Birlouez-Aragon I, Lykkesfeldt J.  2012.  Authors' perspective: What is the optimum intake of vitamin C in humans? Crit Rev Food Sci Nutr. 52(9):815-29.

Zhu B-Z, Antholine WE, Frei B.  2002.  Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex.. Free Radic Biol Med. 32(12):1333-8.

Zhang W-J, Bird KE, McMillen TS, Leboeuf RC, Hagen TM, Frei B.  2008.  Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice.. Circulation. 117(3):421-8.

Wei H, Zhang W-J, McMillen TS, Leboeuf RC, Frei B.  2012.  Copper chelation by tetrathiomolybdate inhibits vascular inflammation and atherosclerotic lesion development in apolipoprotein E-deficient mice.. Atherosclerosis. 223(2):306-13.

Zhang W-J, Wei H, Frei B.  2010.  The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice.. Exp Biol Med (Maywood). 235(5):633-41.

Zhang W-J, Frei B.  2015.  Astragaloside IV inhibits NF- κ B activation and inflammatory gene expression in LPS-treated mice.. Mediators Inflamm. 2015:274314.

Higdon JV, Frei B.  2003.  Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions.. Crit Rev Food Sci Nutr. 43(1):89-143.

Zhang W-J, Wei H, Hagen T, Frei B.  2007.  Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway.. Proc Natl Acad Sci U S A. 104(10):4077-82.

Li L, Smith A, Hagen TM, Frei B.  2010.  Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.. Ann N Y Acad Sci. 1203:151-9.

Wei H, Frei B, Beckman JS, Zhang W-J.  2011.  Copper chelation by tetrathiomolybdate inhibits lipopolysaccharide-induced inflammatory responses in vivo.. Am J Physiol Heart Circ Physiol. 301(3):H712-20.

Lotito SB, Frei B.  2004.  Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects.. Free Radic Biol Med. 36(2):201-11.

Mastaloudis A, Yu T-W, O'Donnell RP, Frei B, Dashwood RH, Traber MG.  2004.  Endurance exercise results in DNA damage as detected by the comet assay.. Free Radic Biol Med. 36(8):966-75.

Yilmazer-Musa M, Griffith AM, Michels AJ, Schneider E, Frei B.  2012.  Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity.. J Agric Food Chem. 60(36):8924-9.

Yilmazer-Musa M, Griffith AM, Michels AJ, Schneider E, Frei B.  2012.  Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity.. J Agric Food Chem. 60(36):8924-9.

Zhu B-Z, Carr AC, Frei B.  2002.  Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damage.. FEBS Lett. 532(1-2):80-4.

Zhu B-Z, Carr AC, Frei B.  2002.  Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damage.. FEBS Lett. 532(1-2):80-4.