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Hagen, Tory M
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Cell Line, Tumor
Shenvi SV
,
Smith EJ
,
Hagen TM
. 2009.
Transcriptional regulation of rat gamma-glutamate cysteine ligase catalytic subunit gene is mediated through a distal antioxidant response element.
.
Pharmacol Res. 60(4):229-36.
Cell Membrane
Smith AR
,
Visioli F
,
Hagen TM
. 2006.
Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age.
.
Arch Biochem Biophys. 454(1):100-5.
Cell Nucleus
Shay KPetersen
,
Michels AJ
,
Li W
,
Kong A-NTony
,
Hagen TM
. 2012.
Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response.
.
Biochim Biophys Acta. 1823(6):1102-9.
Shay KPetersen
,
Smith EJ
,
Hagen TM
. 2010.
Transcription factor Nrf2: examination of nuclear protein levels by immunoblotting and promoter response element binding by chromatin immunoprecipitation (ChIP).
.
Curr Protoc Toxicol. Chapter 17:Unit17.13.
Cell Survival
Shay KPetersen
,
Hagen TM
. 2009.
Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.
.
Biogerontology. 10(4):443-56.
Cells, Cultured
Smith AR
,
Visioli F
,
Hagen TM
. 2006.
Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age.
.
Arch Biochem Biophys. 454(1):100-5.
Smith EJ
,
Shay KP
,
Thomas NO
,
Butler JA
,
Finlay LF
,
Hagen TM
. 2015.
Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a.
.
Free Radic Biol Med. 89:1184-91.
Smith AR
,
Visioli F
,
Hagen TM
. 2002.
Vitamin C matters: increased oxidative stress in cultured human aortic endothelial cells without supplemental ascorbic acid.
.
FASEB J. 16(9):1102-4.
Shay KPetersen
,
Hagen TM
. 2009.
Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.
.
Biogerontology. 10(4):443-56.
Shay KPetersen
,
Smith EJ
,
Hagen TM
. 2010.
Transcription factor Nrf2: examination of nuclear protein levels by immunoblotting and promoter response element binding by chromatin immunoprecipitation (ChIP).
.
Curr Protoc Toxicol. Chapter 17:Unit17.13.
Robinson KM
,
Janes MS
,
Pehar M
,
Monette JS
,
Ross MF
,
Hagen TM
,
Murphy MP
,
Beckman JS
. 2006.
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes.
.
Proc Natl Acad Sci U S A. 103(41):15038-43.
Shenvi SV
,
Smith EJ
,
Hagen TM
. 2009.
Transcriptional regulation of rat gamma-glutamate cysteine ligase catalytic subunit gene is mediated through a distal antioxidant response element.
.
Pharmacol Res. 60(4):229-36.
Ceramides
Smith AR
,
Visioli F
,
Frei B
,
Hagen TM
. 2006.
Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.
.
Aging Cell. 5(5):391-400.
Cerebral Cortex
Suh JH
,
Moreau R
,
Heath S-HD
,
Hagen TM
. 2005.
Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.
.
Redox Rep. 10(1):52-60.
Cholesterol
Zhang W-J
,
Bird KE
,
McMillen TS
,
Leboeuf RC
,
Hagen TM
,
Frei B
. 2008.
Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice.
.
Circulation. 117(3):421-8.
Chromatin Immunoprecipitation
Shay KPetersen
,
Smith EJ
,
Hagen TM
. 2010.
Transcription factor Nrf2: examination of nuclear protein levels by immunoblotting and promoter response element binding by chromatin immunoprecipitation (ChIP).
.
Curr Protoc Toxicol. Chapter 17:Unit17.13.
Shenvi SV
,
Smith EJ
,
Hagen TM
. 2009.
Transcriptional regulation of rat gamma-glutamate cysteine ligase catalytic subunit gene is mediated through a distal antioxidant response element.
.
Pharmacol Res. 60(4):229-36.
Chromatography, High Pressure Liquid
Michels AJ
,
Joisher N
,
Hagen TM
. 2003.
Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes.
.
Arch Biochem Biophys. 410(1):112-20.
Robinson KM
,
Janes MS
,
Pehar M
,
Monette JS
,
Ross MF
,
Hagen TM
,
Murphy MP
,
Beckman JS
. 2006.
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes.
.
Proc Natl Acad Sci U S A. 103(41):15038-43.
Circadian Rhythm
Finlay LA
,
Michels AJ
,
Butler JA
,
Smith EJ
,
Monette JS
,
Moreau RF
,
Petersen SKate
,
Frei B
,
Hagen TM
. 2012.
R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.
.
Am J Physiol Regul Integr Comp Physiol. 302(5):R587-97.
Circadian Rhythm Signaling Peptides and Proteins
Finlay LA
,
Michels AJ
,
Butler JA
,
Smith EJ
,
Monette JS
,
Moreau RF
,
Petersen SKate
,
Frei B
,
Hagen TM
. 2012.
R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.
.
Am J Physiol Regul Integr Comp Physiol. 302(5):R587-97.
Citrate (si)-Synthase
Moreau R
,
Heath S-HD
,
Doneanu CE
,
Harris RA
,
Hagen TM
. 2004.
Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart.
.
Biochem Biophys Res Commun. 325(1):48-58.
Coenzyme A
Moreau R
,
Heath S-HD
,
Doneanu CE
,
Harris RA
,
Hagen TM
. 2004.
Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart.
.
Biochem Biophys Res Commun. 325(1):48-58.
Creatine Kinase
Moreau R
,
Heath S-HD
,
Doneanu CE
,
J Lindsay G
,
Hagen TM
. 2003.
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
.
Antioxid Redox Signal. 5(5):517-27.
Cross-Linking Reagents
Moreau R
,
Heath S-HD
,
Doneanu CE
,
J Lindsay G
,
Hagen TM
. 2003.
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
.
Antioxid Redox Signal. 5(5):517-27.
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