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Found 582 results
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Williams, David E
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Oxygenases
Krueger SK
,
Martin SR
,
Yueh M-F
,
Pereira CB
,
Williams DE
. 2002.
Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein.
.
Drug Metab Dispos. 30(1):34-41.
Henderson MC
,
Siddens LK
,
Krueger SK
,
J Stevens F
,
Kedzie K
,
Fang WK
,
Heidelbaugh T
,
Nguyen P
,
Chow K
,
Garst M
et al.
. 2014.
Flavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones.
.
Toxicol Appl Pharmacol. 278(2):91-9.
Henderson MC
,
Krueger SK
,
Stevens JF
,
Williams DE
. 2004.
Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione.
.
Chem Res Toxicol. 17(5):633-40.
Siddens LK
,
Henderson MC
,
VanDyke JE
,
Williams DE
,
Krueger SK
. 2008.
Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms.
.
Biochem Pharmacol. 75(2):570-9.
Krueger SK
,
Henderson MC
,
Siddens LK
,
VanDyke JE
,
Benninghoff AD
,
P Karplus A
,
Furnes B
,
Schlenk D
,
Williams DE
. 2009.
Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.
.
Drug Metab Dispos. 37(8):1785-91.
Oxygen
Traber MG
,
Siddens LK
,
Leonard SW
,
Schock B
,
Gohil K
,
Krueger SK
,
Cross CE
,
Williams DE
. 2005.
Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.
.
Free Radic Biol Med. 38(6):773-85.
Oxidoreductases, N-Demethylating
Traber MG
,
Siddens LK
,
Leonard SW
,
Schock B
,
Gohil K
,
Krueger SK
,
Cross CE
,
Williams DE
. 2005.
Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.
.
Free Radic Biol Med. 38(6):773-85.
Oxidation-Reduction
Henderson MC
,
Krueger SK
,
Stevens JF
,
Williams DE
. 2004.
Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione.
.
Chem Res Toxicol. 17(5):633-40.
Krueger SK
,
Henderson MC
,
Siddens LK
,
VanDyke JE
,
Benninghoff AD
,
P Karplus A
,
Furnes B
,
Schlenk D
,
Williams DE
. 2009.
Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.
.
Drug Metab Dispos. 37(8):1785-91.
Henderson MC
,
Siddens LK
,
Krueger SK
,
J Stevens F
,
Kedzie K
,
Fang WK
,
Heidelbaugh T
,
Nguyen P
,
Chow K
,
Garst M
et al.
. 2014.
Flavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones.
.
Toxicol Appl Pharmacol. 278(2):91-9.
Organoselenium Compounds
Rajendran P
,
Williams DE
,
Ho E
,
Dashwood RH
. 2011.
Metabolism as a key to histone deacetylase inhibition.
.
Crit Rev Biochem Mol Biol. 46(3):181-99.
Oncorhynchus mykiss
Simonich MT
,
McQuistan T
,
Jubert C
,
Pereira C
,
Hendricks JD
,
Schimerlik M
,
Zhu B
,
Dashwood RH
,
Williams DE
,
Bailey GS
. 2008.
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout.
.
Food Chem Toxicol. 46(3):1014-24.
Tilton SC
,
Givan SA
,
Pereira CB
,
Bailey GS
,
Williams DE
. 2006.
Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout.
.
Toxicol Sci. 90(1):61-72.
McQuistan TJ
,
Simonich MT
,
M Pratt M
,
Pereira CB
,
Hendricks JD
,
Dashwood RH
,
Williams DE
,
Bailey GS
. 2012.
Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study.
.
Food Chem Toxicol. 50(2):341-52.
Williams DE
. 2012.
The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention.
.
Comp Biochem Physiol C Toxicol Pharmacol. 155(1):121-7.
Oligonucleotide Array Sequence Analysis
Tilton SC
,
Givan SA
,
Pereira CB
,
Bailey GS
,
Williams DE
. 2006.
Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout.
.
Toxicol Sci. 90(1):61-72.
Nutrigenomics
Parasramka MA
,
Ho E
,
Williams DE
,
Dashwood RH
. 2012.
MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals.
.
Mol Carcinog. 51(3):213-30.
Nuclear Proteins
Rajendran P
,
Kidane AI
,
Yu T-W
,
Dashwood W-M
,
Bisson WH
,
Löhr CV
,
Ho E
,
Williams DE
,
Dashwood RH
. 2013.
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.
.
Epigenetics. 8(6):612-23.
NF-E2-Related Factor 2
Johnson GS
,
Li J
,
Beaver LM
,
W Dashwood M
,
Sun D
,
Rajendran P
,
Williams DE
,
Ho E
,
Dashwood RH
. 2017.
A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells.
.
Mol Nutr Food Res. 61(4)
Neurons
Leibelt DA
,
Hedstrom OR
,
Fischer KA
,
Pereira CB
,
Williams DE
. 2003.
Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3'-diindolylmethane in sprague-dawley rats.
.
Toxicol Sci. 74(1):10-21.
Neoplasms, Multiple Primary
Simonich MT
,
McQuistan T
,
Jubert C
,
Pereira C
,
Hendricks JD
,
Schimerlik M
,
Zhu B
,
Dashwood RH
,
Williams DE
,
Bailey GS
. 2008.
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout.
.
Food Chem Toxicol. 46(3):1014-24.
Neoplasms, Experimental
Bailey GS
,
Reddy AP
,
Pereira CB
,
Harttig U
,
Baird W
,
Spitsbergen JM
,
Hendricks JD
,
Orner GA
,
Williams DE
,
Swenberg JA
. 2009.
Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study.
.
Chem Res Toxicol. 22(7):1264-76.
Wang R
,
W Dashwood M
,
Bailey GS
,
Williams DE
,
Dashwood RH
. 2006.
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.
.
Mutat Res. 601(1-2):11-8.
Neoplasms
McQuistan TJ
,
Simonich MT
,
M Pratt M
,
Pereira CB
,
Hendricks JD
,
Dashwood RH
,
Williams DE
,
Bailey GS
. 2012.
Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study.
.
Food Chem Toxicol. 50(2):341-52.
Chen Y-S
,
Wang R
,
Dashwood W-M
,
Löhr CV
,
Williams DE
,
Ho E
,
Mertens-Talcott S
,
Dashwood RH
. 2017.
A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat.
.
Arch Toxicol. 91(10):3415-3425.
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