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Faculty and Staff
Our Research
Micronutrient Information
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Biblio
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Gombart, Adrian F
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Gene Expression Regulation
Gombart AF
. 2009.
The vitamin D-antimicrobial peptide pathway and its role in protection against infection.
.
Future Microbiol. 4(9):1151-65.
Giant Cells
Jiang J
,
Chen S
,
Wang H
,
Carlson MA
,
Gombart AF
,
Xie J
. 2018.
CO-expanded nanofiber scaffolds maintain activity of encapsulated bioactive materials and promote cellular infiltration and positive host response.
.
Acta Biomater. 68:237-248.
Glucose
Logan IE
,
Shulzhenko N
,
Sharpton TJ
,
Bobe G
,
Liu K
,
Nuss S
,
Jones ML
,
Miranda CL
,
Vasquez-Perez S
,
Pennington JM
et al.
. 2021.
Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice.
.
Mol Nutr Food Res. 65(21):e2100389.
HEK293 Cells
Yang L
,
Broderick D
,
Campbell Y
,
Gombart AF
,
Stevens JF
,
Jiang Y
,
Hsu VL
,
Bisson WH
,
Maier CS
. 2016.
Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies.
.
Biochim Biophys Acta. 1864(12):1667-1677.
Histone Deacetylases
Campbell Y
,
Fantacone ML
,
Gombart AF
. 2012.
Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism.
.
Eur J Nutr. 51(8):899-907.
HT29 Cells
Guo C
,
Rosoha E
,
Lowry MB
,
Borregaard N
,
Gombart AF
. 2013.
Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway.
.
J Nutr Biochem. 24(5):754-9.
Human Umbilical Vein Endothelial Cells
Su Y
,
Sharma NShree
,
John JV
,
Ganguli-Indra G
,
Indra AK
,
Gombart AF
,
Xie J
. 2022.
Engineered Exosomes Containing Cathelicidin/LL-37 Exhibit Multiple Biological Functions.
.
Adv Healthc Mater. 11(20):e2200849.
Humans
Campbell Y
,
Fantacone ML
,
Gombart AF
. 2012.
Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism.
.
Eur J Nutr. 51(8):899-907.
Lowry MB
,
Guo C
,
Zhang Y
,
Fantacone ML
,
Logan IE
,
Campbell Y
,
Zhang W
,
Le M
,
Indra AK
,
Ganguli-Indra G
et al.
. 2020.
A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression.
.
J Steroid Biochem Mol Biol. 198:105552.
Yang L
,
Broderick D
,
Campbell Y
,
Gombart AF
,
Stevens JF
,
Jiang Y
,
Hsu VL
,
Bisson WH
,
Maier CS
. 2016.
Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies.
.
Biochim Biophys Acta. 1864(12):1667-1677.
Gombart AF
. 2009.
The vitamin D-antimicrobial peptide pathway and its role in protection against infection.
.
Future Microbiol. 4(9):1151-65.
Guo C
,
Rosoha E
,
Lowry MB
,
Borregaard N
,
Gombart AF
. 2013.
Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway.
.
J Nutr Biochem. 24(5):754-9.
Carr AC
,
Gombart AF
. 2022.
Multi-Level Immune Support by Vitamins C and D during the SARS-CoV-2 Pandemic.
.
Nutrients. 14(3)
Chen S
,
Liu B
,
Carlson MA
,
Gombart AF
,
Reilly DA
,
Xie J
. 2017.
Recent advances in electrospun nanofibers for wound healing.
.
Nanomedicine (Lond). 12(11):1335-1352.
Calder PC
,
Carr AC
,
Gombart AF
,
Eggersdorfer M
. 2020.
Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections.
.
Nutrients. 12(4)
Guo C
,
Sinnott B
,
Niu B
,
Lowry MB
,
Fantacone ML
,
Gombart AF
. 2014.
Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids.
.
Mol Nutr Food Res. 58(3):528-536.
Su Y
,
Sharma NShree
,
John JV
,
Ganguli-Indra G
,
Indra AK
,
Gombart AF
,
Xie J
. 2022.
Engineered Exosomes Containing Cathelicidin/LL-37 Exhibit Multiple Biological Functions.
.
Adv Healthc Mater. 11(20):e2200849.
Nakamura Y
,
Kulkarni NN
,
Takahashi T
,
Alimohamadi H
,
Dokoshi T
,
Liu E
,
Shia M
,
Numata T
,
Luo EWc
,
Gombart AF
et al.
. 2024.
Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis.
.
J Clin Invest. 134(5)
Gombart AF
,
Saito T
,
H Koeffler P
. 2009.
Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.
.
BMC Genomics. 10:321.
Dhawan P
,
Wei R
,
Sun C
,
Gombart AF
,
H Koeffler P
,
Diamond G
,
Christakos S
. 2015.
C/EBPα and the Vitamin D Receptor Cooperate in the Regulation of Cathelicidin in Lung Epithelial Cells.
.
J Cell Physiol. 230(2):464-72.
Lowry MB
,
Guo C
,
Borregaard N
,
Gombart AF
. 2014.
Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells.
.
J Steroid Biochem Mol Biol. 143:183-91.
Eggersdorfer M
,
Berger MM
,
Calder PC
,
Gombart AF
,
Ho E
,
Laviano A
,
Meydani SN
. 2022.
Perspective: Role of Micronutrients and Omega-3 Long-Chain Polyunsaturated Fatty Acids for Immune Outcomes of Relevance to Infections in Older Adults-A Narrative Review and Call for Action.
.
Adv Nutr. 13(5):1415-1430.
Aloul KM
,
Nielsen JEilsø
,
Defensor EB
,
Lin JS
,
Fortkort JA
,
Shamloo M
,
Cirillo JD
,
Gombart AF
,
Barron AE
. 2022.
Upregulating Human Cathelicidin Antimicrobial Peptide LL-37 Expression May Prevent Severe COVID-19 Inflammatory Responses and Reduce Microthrombosis.
.
Front Immunol. 13:880961.
Kerr DCR
,
Zava DT
,
Piper WT
,
Saturn SR
,
Frei B
,
Gombart AF
. 2015.
Associations between vitamin D levels and depressive symptoms in healthy young adult women.
.
Psychiatry Res. 227(1):46-51.
Gombart AF
,
Michels AJ
,
Eggersdorfer M
. 2023.
There is no evidence that vitamin D supplementation drives the progression of Alzheimer's disease.
.
Aging Cell. 22(1):e13758.
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