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Faculty and Staff
Our Research
Micronutrient Information
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Leonard, Scott W
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gamma-Tocopherol
Traber MG
,
Leonard SW
,
Vasu VT
,
Morrissey BM
,
Lei HJohn
,
Atkinson J
,
Cross CE
. 2022.
α-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration.
.
Nutrients. 14(18)
Gastrointestinal Microbiome
Logan IE
,
Shulzhenko N
,
Sharpton TJ
,
Bobe G
,
Liu K
,
Nuss S
,
Jones ML
,
Miranda CL
,
Vasquez-Perez S
,
Pennington JM
et al.
. 2021.
Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice.
.
Mol Nutr Food Res. 65(21):e2100389.
Gene Expression Regulation
Bella DL
,
Schock BC
,
Lim Y
,
Leonard SW
,
Berry C
,
Cross CE
,
Traber MG
. 2006.
Regulation of the alpha-tocopherol transfer protein in mice: lack of response to dietary vitamin E or oxidative stress.
.
Lipids. 41(2):105-12.
Genotype
Traber MG
,
Siddens LK
,
Leonard SW
,
Schock B
,
Gohil K
,
Krueger SK
,
Cross CE
,
Williams DE
. 2005.
Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.
.
Free Radic Biol Med. 38(6):773-85.
Glucose
Logan IE
,
Shulzhenko N
,
Sharpton TJ
,
Bobe G
,
Liu K
,
Nuss S
,
Jones ML
,
Miranda CL
,
Vasquez-Perez S
,
Pennington JM
et al.
. 2021.
Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice.
.
Mol Nutr Food Res. 65(21):e2100389.
Hepatocytes
Traber MG
,
Labut EM
,
Leonard SW
,
Lebold KM
. 2011.
α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes.
.
Free Radic Biol Med. 51(11):2031-40.
Humans
Leonard SW
,
Good CK
,
Gugger ET
,
Traber MG
. 2004.
Vitamin E bioavailability from fortified breakfast cereal is greater than that from encapsulated supplements.
.
Am J Clin Nutr. 79(1):86-92.
Leonard SW
,
Bruno RS
,
Paterson E
,
Schock BC
,
Atkinson J
,
Bray TM
,
Cross CE
,
Traber MG
. 2003.
5-nitro-gamma-tocopherol increases in human plasma exposed to cigarette smoke in vitro and in vivo.
.
Free Radic Biol Med. 35(12):1560-7.
Matsumoto S
,
Traber MG
,
Leonard SW
,
Choi J
,
Fang X
,
Maishan M
,
Wick KD
,
Jones KD
,
Calfee CS
,
Gotts JE
et al.
. 2022.
Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages.
.
Am J Physiol Lung Cell Mol Physiol. 322(6):L771-L783.
Bobe G
,
Cobb TJ
,
Leonard SW
,
Aponso S
,
Bahro CB
,
Koley D
,
Mah E
,
Bruno RS
,
Traber MG
. 2017.
Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome.
.
Redox Biol. 12:121-128.
Pei R
,
Mah E
,
Leonard SW
,
Traber MG
,
Bruno RS
. 2015.
α-Tocopherol supplementation reduces 5-nitro-γ-tocopherol accumulation by decreasing γ-tocopherol in young adult smokers.
.
Free Radic Res. 49(9):1114-1121.
Traber MG
,
Leonard SW
,
Vasu VT
,
Morrissey BM
,
Lei HJohn
,
Atkinson J
,
Cross CE
. 2022.
α-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration.
.
Nutrients. 14(18)
Leonard SW
,
Traber MG
. 2006.
Measurement of the vitamin E metabolites, carboxyethyl hydroxychromans (CEHCs), in biological samples.
.
Curr Protoc Toxicol. Chapter 7:Unit7.8.
Traber MG
,
Siddens LK
,
Leonard SW
,
Schock B
,
Gohil K
,
Krueger SK
,
Cross CE
,
Williams DE
. 2005.
Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.
.
Free Radic Biol Med. 38(6):773-85.
Farley SM
,
Leonard SW
,
Taylor AW
,
Birringer M
,
Edson KZ
,
Rettie AE
,
Traber MG
. 2013.
ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol.
.
Mol Nutr Food Res. 57(10):1785-93.
Bruno RS
,
Leonard SW
,
Li J
,
Bray TM
,
Traber MG
. 2005.
Lower plasma alpha-carboxyethyl-hydroxychroman after deuterium-labeled alpha-tocopherol supplementation suggests decreased vitamin E metabolism in smokers.
.
Am J Clin Nutr. 81(5):1052-9.
Traber MG
,
Leonard SW
,
Ebenuwa I
,
Violet P-C
,
Wang Y
,
Niyyati M
,
Padayatty S
,
Tu H
,
Courville A
,
Bernstein S
et al.
. 2019.
Vitamin E absorption and kinetics in healthy women, as modulated by food and by fat, studied using 2 deuterium-labeled α-tocopherols in a 3-phase crossover design.
.
Am J Clin Nutr. 110(5):1148-1167.
Traber MG
,
Leonard SW
,
Bobe G
,
Fu X
,
Saltzman E
,
Grusak MA
,
Booth SL
. 2015.
α-Tocopherol disappearance rates from plasma depend on lipid concentrations: studies using deuterium-labeled collard greens in younger and older adults.
.
Am J Clin Nutr. 101(4):752-9.
Leonard SW
,
Bruno RS
,
Ramakrishnan R
,
Bray T
,
Traber MG
. 2004.
Cigarette smoking increases human vitamin E requirements as estimated by plasma deuterium-labeled CEHC.
.
Ann N Y Acad Sci. 1031:357-60.
Traber MG
,
Leonard SW
,
Traber DL
,
Traber LD
,
Gallagher J
,
Bobe G
,
Jeschke MG
,
Finnerty CC
,
Herndon D
. 2010.
α-Tocopherol adipose tissue stores are depleted after burn injury in pediatric patients.
.
Am J Clin Nutr. 92(6):1378-84.
Traber MG
,
Mah E
,
Leonard SW
,
Bobe G
,
Bruno RS
. 2017.
Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial.
.
Am J Clin Nutr. 105(3):571-579.
Tennant KG
,
Leonard SW
,
Wong CP
,
Iwaniec UT
,
Turner RT
,
Traber MG
. 2017.
High-Dietary Alpha-Tocopherol or Mixed Tocotrienols Have No Effect on Bone Mass, Density, or Turnover in Male Rats During Skeletal Maturation.
.
J Med Food. 20(7):700-708.
Bruno RS
,
Leonard SW
,
Atkinson J
,
Montine TJ
,
Ramakrishnan R
,
Bray TM
,
Traber MG
. 2006.
Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation.
.
Free Radic Biol Med. 40(4):689-97.
Hydroxylation
Farley SM
,
Leonard SW
,
Taylor AW
,
Birringer M
,
Edson KZ
,
Rettie AE
,
Traber MG
. 2013.
ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol.
.
Mol Nutr Food Res. 57(10):1785-93.
Hyperlipidemias
Lebold KM
,
Grant KA
,
Freeman WM
,
Wiren KM
,
Miller GW
,
Kiley C
,
Leonard SW
,
Traber MG
. 2011.
Individual differences in hyperlipidemia and vitamin E status in response to chronic alcohol self-administration in cynomolgus monkeys.
.
Alcohol Clin Exp Res. 35(3):474-83.
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