Linus Pauling Institute

A Tribute to Balz Frei

Dietary Components and the Micrbiome

Lipid Metabolism

Update on Vitamin E

Bioactives and Cancer Prevention

Metabolism of Bioactives (Polyphenols)

Nutrition and Brain Health

Lightning Talks

Mechanisms of Vitamin C in Cancer

IV Vitamin C Therapy in Cancer

IV Vitamin C Therapy in Sepsis

Bioactives

Poster Abstract 1
Design and development of a reporter plasmid for high-throughput screening of botanical extracts and small molecule libraries to discover prenylated flavonoid ligands of FXR
Isabelle Logan, Linus Pauling Institute, Oregon State University

Poster Abstract 2
Effects of nitrate and nitrite exposure on zebrafish behavior and brain metabolic phenotyping
Manuel Garcia-Jaramillo, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 3
Metabolism of xanthohumol and 8-prenylnaringenin by intestinal microbiota
Ines Paraiso, Linus Pauling Institute, Oregon State University

Poster Abstract 4
Characterization and quantification of phytochemical constituents in the medicinal herb Centella asiatica by high-resolution mass spectrometry
Armando Alcazar Magana, Oregon State University

Poster Abstract 5
Profiling of specific metabolic signatures in deuterium labeled and unlabeled broccoli sprouts with X13CMS
Jaewoo Choi, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 6
Diet–gut microbiota interactions mediated by hop-derived xanthohumols in a mouse obesity model
Johana Revel, Linus Pauling Institute, Oregon State University

Poster Abstract 7
A novel nutritional formulation containing the prebiotic human milk oligosaccharide 2’-fucosyllactose reduces gastrointestinal symptoms and beneficially alters the gut microbiome in adults with gastrointestinal dysfunction
Jennifer Ryan, ND, National University of Natural Medicine

Poster Abstract 8
Supplementation of mice fed a high fat diet with xanthohumol and its derivatives changes the composition of the fecal microbiota and is associated with observed metabolic improvements
Yang Zhang, Linus Pauling Institute, Oregon State University

Poster Abstract 9
Hepatic and gut microbial metabolism of the hop nutraceutical, xanthohumol, in humans
Lea-Sophie Ullrich, Linus Pauling Institute, Oregon State University

Poster Abstract 10
Green tea extract improves microbiota composition and intestinal barrier function to prevent dietary fat-induced obesity by limiting gut-derived endotoxin translocation and adipose TLR4/NFκB inflammation
Priyankar Dey, PhD, The Ohio State University

Poster Abstract 11
Green tea treatment in obese mice with nonalcoholic steatohepatitis lowers hepatic NFκB activation in association with altered relative abundance of phosphatidylcholine and bile acid metabolites
Geoffrey Sasaki, The Ohio State University

Poster Abstract 12
Effects of dietary resveratrol on the fecundity of a novel model, Nothobranchius guentheri
Andrew Drake, Linus Pauling Institute, Oregon State University

Poster Abstract 13
Antiviral activity of scorpion venom peptides
Victor Huerta, PrevenOx Orthomolecular Biomedical Research

Poster Abstract 14
To whom the side effect of licorice, pseudoaldosteronism, will occur: Case-control study
Tetsuhiro Yoshino, Linus Pauling Institute, Oregon State University

Healthy Diets

Poster Abstract 20
Optimizing gut flora for optimum health and disease prevention
Anyanwu Chukwudi, University of Nigeria

Poster Abstract 21
Eat more plants! A community-based approach to early nutrition education
Megan Kuntz, Western University of Health Sciences, COMP-Northwest

Poster Abstract 22
Rural kid’s cooking camp emphasizing a plant-based diet survey study
Leah Nelson, Western University of the Health Sciences, COMP-Northwest

Poster Abstract 23
Assessment of gut microbiome role in diet-related changes in cognition
Kathy Magnusson, DVM, PhD Linus Pauling Institute, Oregon State University

Poster Abstract 24
The cathelicidin antimicrobial peptide gene alters the gut microbiota of mice
Miles Rouches, Oregon State University

Poster Abstract 25
Dairy milk, regardless of fat content, protects against postprandial hyperglycemia-mediated oxidative stress, dysregulated arginine metabolism and increases in endothelin-1 in prediabetic adults
Joshua McDonald, The Ohio State University

HealthSPAN and Aging

Poster Abstract 30
Age-related loss of hepatic Nrf2 protein homeostasis is attributed to heightened expression of miR-146a
Nicholas Thomas, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 31
The role of proteostasis in protein aggregation in long-lived species
Bharath Sunchu, Linus Pauling Institute, Oregon State University

Poster Abstract 32
Dietary restriction improves cognitive performance and maintains hepatic Sirt7 levels in Nothobranchius guentheri, a short-lived model of aging
Kate Petersen Shay, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 33
Long-term supplementation with a novel nutrient blend mimics calorie restriction transcriptomics in multiple tissues of old mice
Angela Mastaloudis, PhD, Nu Skin Enterprises

Poster Abstract 34
Rapamycin inhibits the secretory phenotype of senescent cells by an Nrf2-independent mechanism
Rong Wang, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 35
Safe and proven daily actions to improve your healthspan
Alfred “Roc” Ordman, PhD, Beloit College

Poster Abstract 36
Cellular Senescence Contributes to Hepatic “Inflamm-aging”
Amanda Kelley, Linus Pauling Institute, Oregon State University

Vitamins and Minerals

Poster Abstract 40
Adverse effects of arsenic exposure and zinc deficiency on pancreatic beta cells and insulin production
Annie Cao, Linus Pauling Institute, Oregon State University

Poster Abstract 41
Adverse consequences of zinc deficiency and arsenic exposure to zebrafish development
Laura Beaver, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 42
Interactions between arsenic exposure and zinc deficiency on zinc status, oxidative stress, and inflammatory response
Carmen Wong, PhD, Linus Pauling Institute, Oregon State University

Poster Abstract 43
Ascorbate deficiency and mitochondrial dysfunction in the APP/PSEN1 mouse models of Alzheimer’s disease
Shilpy Dixit, Vanderbilt University

Poster Abstract 44
Local sustained delivery of 1α,25(OH)2D3 by nanofiber wound dressings induces human cathelicidin antimicrobial peptide expression both in vitro and in vivo
Yang Zhang, Linus Pauling Institute, Oregon State University
Poster Abstract 45
Chronic vitamin E deficiency in adult zebrafish dysregulates brain lipids, energy metabolism, and cognitive function
Scott Leonard, MS, Linus Pauling Institute, Oregon State University

Cancer

Poster Abstract 50
Application of Quantitative Redox Biology to basic research on the use of pharmacological ascorbate in cancer therapy
Garry Buettner, PhD, The University of Iowa

Poster Abstract 51
4D quantitative image analysis of cancer cell invasion in a brain microenvironment using ImageJ software
John Gamble, Oregon State University

Poster Abstract 52
Primary T-cell lymphoblastic leukemia (T-ALL) xenotransplant in zebrafish as a model for chemoprevention
Youngjoo Lee, Linus Pauling Institute, Oregon State University

Poster Abstract 53
The aryl hydrocarbon receptor mediates growth-inhibitory effects of SU5416 in hepatoma cells
Hyo Sang Jang, Oregon State University

Poster Abstract 54
Targeting therapy resistant cancer through Bcl-2 functional conversion
Martin Pearce, Oregon State University

Poster Abstract 55
AhR-dependent induction of p27Kip1 by select AhR ligands
Veronica Puig-Sanvicens, PhD, Oregon State University

Poster Abstract 56
Grain legume consumption may provide chemo-preventive effects on incident and prevalent colorectal adenoma and colorectal cancer: A meta-analysis of human studies
Thushanthi Perera, Linus Pauling Institute, Oregon State University

Poster Abstract 57
Chemopreventive response markers to navy bean extract in a mouse model of inflammation-induced colorectal cancer
Gerd Bobe, PhD, Linus Pauling Institute, Oregon State University