Donald B. Jump, Ph.D.

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Dr. Donald B. Jump
 

Principal Investigator, Linus Pauling Institute

Professor, Nutrition Program, College of Health


Contact:

107A Milam Hall
541-737-4007
[email protected]

Research Interests

My 40-year research career, first at Michigan State University and now at Oregon State University, has focused on defining how fatty acids (omega-3 polyunsaturated fatty acids [PUFA]) and glucose regulate hepatic gene expression. Over the years this research has shifted to examine the molecular basis for dietary fat as a control of hepatic health. As such, my colleagues and I, in the Molecular Nutrition and Diabetes Research Lab at OSU, investigate the molecular and metabolic basis of complications associated with obesity and diabetes. Specifically, our current focus is on the role diet plays in the onset and progression of nonalcoholic fatty liver disease (NAFLD), a major global health problem.

The central theme of our research is that dietary fat plays a major role in the control of transcriptional regulatory networks affecting carbohydrate, lipid, and protein metabolism. Consumption of high-fat diets or diets with insufficient PUFA (omega-3 and omega-6 PUFA) contribute to the complications associated with obesity and type 2 diabetes. Such changes in dietary PUFA content disrupt regulatory networks controlling cell function. These events lead to complications of diabetes, such as hyperglycemia, dyslipidemia, cardiovascular disease, and fatty liver disease.

Our experimental approach employs a preclinical mouse model to assess the impact of specific dietary factors on the onset, progression, and remission of NAFLD. Our goal is to develop a nutritional strategy to attenuate disease progression and promote disease remission.

Education

  • B.S., Biology, Delaware State College (University)
  • M.S., Biology, Rutgers University
  • Ph.D., Biochemistry, Georgetown University
  • Postdoctoral Fellowship and Research Assistant Professor of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, University of Minnesota

Research Support

The National Institutes of Health (DK112360m, DK094600)

The US Department of Agriculture (2009-65200-05846)

Featured Publications

Spooner MH, Jump DB. (2023) Nonalcoholic fatty liver disease and omega-3 fatty acids: mechanisms and clinical use. Annu Rev Nutr. 43:199-223. doi: 10.1146/annurev-nutr-061021-030223.

Padiadpu J, Garcia-Jaramillo M, Newman NK, Pederson JW, Rodrigues R, Li Z, Singh S, Monnier P, Trinchieri G, Brown K, Dzutsev AK, Shulzhenko N, Jump DB, Morgun A. (2023) Multi-omic network analysis identified betacellulin as a novel target of omega-3 fatty acid attenuation of western diet-induced nonalcoholic steatohepatitis. EMBO Mol Med. 5(11):e18367. doi: 10.15252/emmm.202318367.

Padiadpu J, Spooner MH, Li Z, Newman N, Löhr CV, Apperson KD, Dzutsev A, Trinchieri G, Shulzhenko N, Morgun A, Jump DB. (2023) Early transcriptome changes associated with western diet induced NASH in Ldlr-/- mice points to activation of hepatic macrophages and an acute phase responseFront Nutr. 10:1147602. doi: 10.3389/fnut.2023.1147602.

Spooner MH, Garcia-Jaramillo M, Apperson KD, Löhr CV, Jump DB. (2023) Time course of western diet (WD) induced nonalcoholic steatohepatitis (NASH) in female and male Ldlr-/- micePLoS One. 11;18(10):e0292432. doi: 10.1371/journal.pone.0292432.

García-Jaramillo M, Lytle KA, Spooner MH, Jump DB. (2019) A lipidomic analysis of docosahexaenoic acid (22:6, ω3) mediated attenuation of Western diet induced nonalcoholic steatohepatitis in male Ldlr -/- mice. Metabolites. 9(11):252. doi: 10.3390/metabo9110252.

Full Publication List from PubMed