OREGON STATE UNIVERSITY
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Principal Investigator, Linus Pauling Institute
Director, Nutrition Graduate Program, College of Public Health and Human Sciences
Professor, School of Biological and Population Health Sciences
Contact Information
107A Milam Hall
541-737-4007 / 541-737-6914
[email protected]
My colleagues and I, in the Molecular Nutrition and Diabetes Research lab, investigate the molecular and metabolic basis of complications associated with obesity and diabetes. Our current focus is on the role diet plays in the onset and progression of nonalcoholic fatty liver disease (NAFLD), a major global health problem.
The central theme of our research is that dietary fat plays a central role in the control of transcriptional regulatory networks regulating carbohydrate, lipid and protein metabolism. Consumption of high fat diets or diets with insufficient polyunsaturated fats (omega 6 and omega 3 fats) contribute to the complications associated with obesity and type 2 diabetes. Such changes in dietary fat content disrupts regulatory networks controlling cell function. These events lead to complications of diabetes, such as hyperglycemia, dyslipidemia, cardiovascular disease and fatty liver disease.
Our experimental approach employs a preclinical mouse model to assess the impact of specific dietary factors on the onset, progression and remission of NAFLD. Our goal is to develop a nutritional strategy to attenuate disease progression and promote disease remission.
The National Institutes of Health supports our research (DK112360).
Jump DB, Depner CM, Tripathy S & Lytle, KA. (2016). Impact of dietary fat on the development of non-alcoholic fatty liver disease (NAFLD) in Ldlr-/-mice. Proceedings of the Nutrition Society 75: 1-9.
Lytle KA & Jump DB. (2016). Is western diet-induced nonalcoholic steatohepatitis in Ldlr-/- mice reversible? PLoS One 11(1): e0146942.
Jump DB. (2016). Chronic fatty liver disease. ASBMB Today-Lipid News 15 (4), 6 & 8.
Lytle KA, Depner CM, Wong CP & Jump DB. (2015). Docosahexaenoic acid attenuates western diet-induced hepatic fibrosis in Ldlr-/- mice by targeting the TGFb-Smad3 pathway. Journal of Lipid Research 56: 1936-1946.
Jump DB, Depner CM, Tripathy S & Lytle KA. (2015). Potential for Dietary w3 fatty acids to prevent nonalcoholic fatty liver disease and reduce the risk of primary liver cancer. Advances in Nutrition 6: 694-702.
Tripathy S, Lytle KA, Stevens RD, Bain JR, Newgard CB, Greenberg AS, Huang LS, Jump DB. (2014) Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obease C57BL/6J mice. J Lipid Res 55:1448-1464.
Lebold KM, Kirkwood JS, Taylor AW, Choi J, Barton CL, Miller GW, Du JL, Jump DB, Stevens JF, Tanguay RL, Traber MG. (2013) Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos. Redox Biol 2:105-113.
Depner CM, Traber MG, Bobe G, Kensicki E, Bohren KM, Milne G, Jump DB. (2013) A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR-/- mice. PLoS One 8:e83756.
Jump DB, Tripathy S, Depner CM. (2013) Fatty Acid-regulated transcription factors in the liver. Ann Rev of Nutr 33:249-269.
Depner CM, Philbrick KA, Jump DB. (2013) Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr-/- mouse model of western diet-induced nonalcoholic steatohepatitis. J Nutr 143:315-323.
Tripathy S, Jump DB. (2013) Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice. J Lipid Res 54:71-84.
Jump DB, Depner CM, Tripathy S. (2012) Omega-3 fatty acid supplementation and cardiovascular disease. J Lipid Res 53:2525-2545.
Depner CM, Torres-Gonzalez M, Tripathy S, Milne G, Jump DB. (2012) Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/- mice. J Nutr 142:1495-1503.
Lebold KM, Jump DB, Miller GW, Wright CL, Labut EM, Barton CL, Tanguay RL, Traber MG. (2011) Vitamin E deficiency decreases long-chain PUFA in zebrafish(Danio rerio). J Nutr 141:2113-2118.
Jump DB, Torres-Gonzalez M, Olson LK. (2011) Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. Biochem Pharmacol 81:649-660.
Jump DB. (2011) Fatty acid regulation of hepatic lipid metabolism. Curr Opin Clin Nutr Metab Care 14:115-120.