Principal Investigator, Linus Pauling Institute
Endowed Director, Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health
Professor, College of Public Health and Human Sciences
214 Milam Hall
541-737-9559 / 541-737-6914 (fax)
My research interests are in the area of antioxidants and gene expression and dietary chemoprevention strategies.
I am currently interested in understanding the role of the antioxidant nutrients such as zinc in maintaining DNA integrity and cancer development. Specifically, I am concerned with the effects of zinc status on DNA damage, DNA repair and stress-response signal pathways. We are also becoming interested in the effects of zinc on the immune system, especially as we age. A large proportion of thepopulation does not eat enough zinc, especially the elderly, and hence may be at increased risk for cancer and other disorders.
Another major focus in the lab is dietary approaches for prostate cancer prevention. We are investigating the molecular mechanisms by which some foods such as soy, tea, and cruciferous vegetables may protect against prostate cancer. We are especially focused on the mechanisms of action for the isothiocyanate, sulforaphane.
Conley MN, Wong CP, Duyck KM, Hord N, Ho E, Sharpton TJ. (2016). Aging and serum MCP-1 are associated with gut microbiome composition in a murine model. PeerJ 4:e1854.
Abbas A, Hall JA, Patterson WL 3rd, Ho E, Hsu A, Al-Mulla F, Georgel PT. (2016). Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines. Biochem Cell Biol 94:71-81.
Watson GW, Wickramasekara S, Fang Y, Maier CS, Williams DE, Dashwood RH, Perez VI, Ho E. (2016). HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells. Exp Biol Med (Maywood) 241:1177-1185.
Thomson CA, Ho E, Strom MB. (2016). Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies. Nutr Rev 74:432-443.
Madeen EP, Löhr CV, You H, Siddens LK, Krueger SK, Dashwood RH, Gonzalez FJ, Baird WM, Ho E, Bramer L, Waters KM, Williams DE. (2016). Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. Mol Carcinog. 56:163-171.