Principal Investigator, Linus Pauling Institute
Professor of Medicinal Chemistry, Department of Pharmaceutical Sciences, College of Pharmacy
373 Linus Pauling Science Center
Cancer prevention by dietary antioxidants, and prostate cancer prevention by the carotenoid lycopene. Mass spectrometry-based pharmacological screening of natural products and combinatorial libraries for drug discovery, and high throughput screening to assess drug metabolism, toxicity, and bioavailability.
The van Breemen laboratory (this link opens a new window).
PubMed publication List (opens an external link)
Muchiri RN, van Breemen RB. Single laboratory validation of UHPLC-MS/MS assays for six milk thistle flavonolignans in human serum, J. AOAC Int. https://doi.org/10.1093/jaoacint/qsaa110
Muchiri RN, van Breemen RB. Affinity selection-mass spectrometry for the discovery of pharmacologically active compounds from combinatorial libraries and natural products. J. Mass Spectrom. 2020;e4647. https://doi.org/10.1002/jms.4647
Muchiri RN, van Breemen RB. Single Laboratory Validation of UHPLC-MS/MS Assays for red clover isoflavones in human serum and dietary supplements. J. AOAC Int. 2020; 103: 1160–1166. https://doi.org/10.1093/jaoacint/qsaa033
Nosal DG, Feinstein DL, Chen L, van Breemen RB. Separation and quantification of superwarfarin rodenticide diastereomers—bromadiolone, difenacoum, flocoumafen, brodifacoum, and difethialone—in human plasma. J. AOAC Int. 2020; 103: 770-778. https://doi.org/10.1093/jaoacint/qsaa007
Yu Y, Pauli GF, Huang L, Gan LS, van Breemen RB, Li D, McAlpine JB, Lankin DC, Chen SN. Classification of flavonoid metabolomes via data mining and quantification of hydroxyl NMR signals. Anal. Chem. 2020; 92: 4954–4962. https://doi.org/10.1021/acs.analchem.9b05084
van Breemen RB. Affinity selection-mass spectrometry: Defining the bioactive compounds in complex mixtures of natural products and combinatorial libraries. Curr. Trends Mass Spectrom. 2020; 18: 18-25. https://www.chromatographyonline.com/view/affinity-selection-mass-spectrometry-defining-bioactive-compounds-complex-mixtures-natural-products
van Breemen RB. Role of mass spectrometry in establishing safety and efficacy of botanical dietary supplements. Clin. Mass Spectrom. 2020; 15: 25-28. https://doi.org/10.1016/j.clinms.2019.12.001
Chen L, van Breemen RB. Validation of a sensitive UHPLC-MS/MS method for cytochrome P450 probe substrates caffeine, tolbutamide, dextromethorphan, and alprazolam in human serum reveals drug contamination of serum used for research. J Pharm Biomed Anal. 2019 Nov 10:112983. https://doi.org/10.1016/j.jpba.2019.112983
Feinstein DL, Nosal DG, Ramanathan S, Zhou J, Chen L, Hershow RC, van Breemen RB, Wright E, Hafner JW, Rubinstein I. Effects of vitamin K1 treatment on plasma concentrations of long-acting anticoagulant rodenticide enantiomers following inhalation of contaminated synthetic cannabinoids. Clin Toxicol (Phila). 2019 Nov 18:1-9. https://doi.org/10.1080/15563650.2019.1687903