Richard B. van Breemen, PhDPrincipal Investigator, Linus Pauling Institute

Professor of Medicinal Chemistry, Department of Pharmaceutical Sciences, College of Pharmacy

Contact Information:
305 Linus Pauling Science Center
541-737-5078 / 541-737-5077 (fax)

Research Interests

Cancer prevention by dietary antioxidants, and prostate cancer prevention by the carotenoid lycopene. Mass spectrometry-based pharmacological screening of natural products and combinatorial libraries for drug discovery, and high throughput screening to asses drug metabolism, toxicity and bioavailibility.


Full Publications List (via PubMed)

Chen L, van Breemen RB. Validation of a sensitive UHPLC-MS/MS method for cytochrome P450 probe substrates caffeine, tolbutamide, dextromethorphan, and alprazolam in human serum reveals drug contamination of serum used for research. J Pharm Biomed Anal. 2019 Nov 10:112983. doi: 10.1016/j.jpba.2019.112983. PMID: 31744669

Feinstein DL, Nosal DG, Ramanathan S, Zhou J, Chen L, Hershow RC, van Breemen RB, Wright E, Hafner JW, Rubinstein I. Effects of vitamin K1 treatment on plasma concentrations of long-acting anticoagulant rodenticide enantiomers following inhalation of contaminated synthetic cannabinoids. Clin Toxicol (Phila). 2019 Nov 18:1-9. doi: 10.1080/15563650.2019.1687903. PMID: 31736367

Fang JB, Nikolić D, Lankin DC, Simmler C, Chen SN, Ramos Alvarenga RF, Liu Y, Pauli GF, van Breemen RB. Formation of (2R)- and (2S)-8-Prenylnaringenin Glucuronides by Human UDP-Glucuronosyltransferases. J Agric Food Chem. 2019 Oct 23;67(42):11650-11656. doi: 10.

Rasin A, Devgun JM, Nosal DG, Meehan TJ, van Breemen RB, Thompson TM. Coagulopathy After Synthetic Cannabinoid Use: A Case Report. Ann Intern Med. 2019 Aug 27. doi: 10.7326/L19-0321. PMID: 31450243

Rue EA, Glinski JA, Glinski VB, van Breemen RB. Ion mobility-mass spectrometry for the separation and analysis of procyanidins. J Mass Spectrom. 2019 May 30. doi: 10.1002/jms.4377.

Feinstein DL, Gierzal K, Iqbal A, Kalinin S, Ripper R, Lindeblad M, Zahkarov A, Lyubimov A, van Breemen R, Weinberg G, Rubinstein I. The relative toxicity of brodifacoum enantiomers. Toxicol Lett. 2019 May 15;306:61-65. doi: 10.1016/j.toxlet.2019.02.011. PMID: 30779948

Rubinstein I, van Breemen R, Nosal DG, Weinberg G, Hershow RC, Feinstein DL. Should Cytochrome P450 Inducers be Used to Accelerate Clearance of Brodifacoum from Poisoned Patients? Drugs R D. 2019 Mar;19(1):67-71. doi: 10.1007/s40268-019-0261-4. PMID: 30689138 Free PMC Article

Bolton JL, Dunlap TL, Hajirahimkhan A, Mbachu O, Chen SN, Chadwick L, Nikolic D, van Breemen RB, Pauli GF, Dietz BM. The Multiple Biological Targets of Hops and Bioactive Compounds. Chem Res Toxicol. 2019 Feb 18;32(2):222-233. doi: 10.1021/acs.chemrestox.8b00345. PMID: 30608650

Roberts GK, Gardner D, Foster PM, Howard PC, Lui E, Walker L, van Breemen RB, Auerbach SS, Rider C. Finding the bad actor: Challenges in identifying toxic constituents in botanical dietary supplements. Food Chem Toxicol. 2019 Feb;124:431-438. doi: 10.1016/j.fct.2018.12.026. Epub 2018 Dec 21. Review. PMID: 30582954

Wang S, Dunlap TL, Huang L, Liu Y, Simmler C, Lantvit DD, Crosby J, Howell CE, Dong H, Chen SN, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. Evidence for Chemopreventive and Resilience Activity of Licorice: Glycyrrhiza Glabra and G. Inflata Extracts Modulate Estrogen Metabolism in ACI Rats. Cancer Prev Res (Phila). 2018 Dec;11(12):819-830. doi: 10.1158/1940-6207.CAPR-18-0178. PMID: 30287522

Rush MD, Rue EA, Wong A, Kowalski P, Glinski JA, van Breemen RB. Rapid Determination of Procyanidins Using MALDI-ToF/ToF Mass Spectrometry. J Agric Food Chem. 2018 Oct 31;66(43):11355-11361. doi: 10.1021/acs.jafc.8b04258. PMID: 30286291 Free PMC Article

Abdelkarim H, Marshall MS, Scesa G, Smith RA, Rue E, Marshall J, Elackattu V, Stoskute M, Issa Y, Santos M, Nguyen D, Hauck Z, van Breemen R, Celej MS, Gaponenko V, Bongarzone ER. α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies. Sci Rep. 2018 Aug 20;8(1):12462. doi: 10.1038/s41598-018-30808-9. PMID: 30127535 Free PMC Article

Muchiri RN, Kowal KE, Hensley K, Feinstein DL, van Breemen RB. Analysis of lanthionine ketimine ethyl ester in mouse serum, whole blood and tissues using ultrahigh-pressure liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2018 Nov 30;32(22):1941-1948. doi: 10.1002/rcm.8263. PMID: 30117207

Gaba RC, Kowalski PJ, van Breemen RB. Matrix-Assisted Laser Desorption/Ionization Imaging Portrays Locoregional Drug Delivery. J Vasc Interv Radiol. 2018 Aug;29(8):1109. doi: 10.1016/j.jvir.2017.12.003. PMID: 30055780

Johnson HE, Amarillas C, Bzhelyansky A, Jennens M, Krepich S, Kuszak A, Monagas M, Parisi S, Reif K, Rimmer CA, Stewart J, Szpylka J, Tims MC, Van Breemen R, Zhao H. Standard Method Performance Requirements (SMPRs®) 2018.007: Identification of Skullcap in Raw Materials, Skullcap-Based Dietary Ingredients, and Dietary Supplements. J AOAC Int. 2018 Jul 1;101(4):1266-1267. doi: 10.5740/jaoacint.SMPR2018.007.  PMID: 29986803

Johnson HE, Amarillas C, Bzhelyansky A, Jennens M, Krepich S, Kuszak A, Monagas M, Parisi S, Reif K, Rimmer CA, Stewart J, Szpylka J, Tims MC, Van Breemen R, Zhao H, Coates SG. Standard Method Performance Requirements (SMPRs®) 2018.006: Determination of Select Flavonoids from Skullcap. J AOAC Int. 2018 Jul 1;101(4):1261-1265. doi: 10.5740/jaoacint.SMPR2018.006. No abstract available. PMID: 29986802

Dentali SJ, Amarillas C, Blythe T, Brown PN, Bzhelyansky A, Fields C, Johnson HE, Krepich S, Kuszak A, Metcalfe C, Monagas M, Mudge E, Parisi S, Reif K, Rimmer CA, Sasser M, Solyom AM, Stewart J, Szpylka J, Tims MC, Van Breemen R, You H, Zhao H, Zielinski G, Coates SG. Standard Method Performance Requirements (SMPRs®) 2018.005: Determination of Kavalactones and/or Flavokavains from Kava (Piper methysticum). J AOAC Int. 2018 Jul 1;101(4):1256-1260. doi: 10.5740/jaoacint.SMPR2018.005. PMID: 29986801

van Breemen R, Bzhelyansky A, Es-Safi NE, Jennens M, Johnson HE, Krepich S, Kuszak A, Monagas M, Reif K, Rimmer CA, Solyom AM, Stewart J, Szpylka J, You H, Young K, Zhao H, Zielinski G. Standard Method Performance Requirements (SMPRs®) 2018.004: Determination of trans Resveratrol in Dietary Supplements and Dietary Ingredients. J AOAC Int. 2018 Jul 1;101(4):1254-1255. doi: 10.5740/jaoacint.SMPR2018.004. PMID: 29986800

Lindeblad M, Lyubimov A, van Breemen R, Gierszal K, Weinberg G, Rubinstein I, Feinstein DL. The Bile Sequestrant Cholestyramine Increases Survival in a Rabbit Model of Brodifacoum Poisoning. Toxicol Sci. 2018 Oct 1;165(2):389-395. doi: 10.1093/toxsci/kfy147. PMID: 29897553 Free PMC Article

Rue EA, Rush MD, van Breemen RB. Procyanidins: a comprehensive review encompassing structure elucidation via mass spectrometry. Phytochem Rev. 2018 Feb;17(1):1-16. doi: 10.1007/s11101-017-9507-3. PMID: 29651231 Free PMC Article

Hajirahimkhan A, Mbachu O, Simmler C, Ellis SG, Dong H, Nikolic D, Lankin DC, van Breemen RB, Chen SN, Pauli GF, Dietz BM, Bolton JL. Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication. J Nat Prod. 2018 Apr 27;81(4):966-975. doi: 10.1021/acs.jnatprod.7b01070. PMID: 29641206 Free PMC Article

Marshall MS, Jakubauskas B, Bogue W, Stoskute M, Hauck Z, Rue E, Nichols M, DiAntonio LL, van Breemen RB, Kordower JH, Saavedra-Matiz CA, Bongarzone ER. Analysis of age-related changes in psychosine metabolism in the human brain. PLoS One. 2018 Feb 26;13(2):e0193438. doi: 10.1371/journal.pone.0193438. eCollection 2018. PMID: 29481565 Free PMC Article

Marshall MS, Issa Y, Jakubauskas B, Stoskute M, Elackattu V, Marshall JN, Bogue W, Nguyen D, Hauck Z, Rue E, Karumuthil-Melethil S, Zaric V, Bosland M, van Breemen RB, Givogri MI, Gray SJ, Crocker SJ, Bongarzone ER. Long-Term Improvement of Neurological Signs and Metabolic Dysfunction in a Mouse Model of Krabbe's Disease after Global Gene Therapy. Mol Ther. 2018 Mar 7;26(3):874-889. doi: 10.1016/j.ymthe.2018.01.009. PMID: 29433937 Free PMC Article

Morrison JD, Schlager CK, Lee AE, van Breemen RB, Gaba RC. Does doxorubicin survive thermal ablation? Results of an ex vivo bench top study. Diagn Interv Radiol. 2018 Jan-Feb;24(1):28-30. doi: 10.5152/dir.2018.17382. PMID: 29317375 Free PMC Article

Rubinstein I, Weinberg G, van Breemen R, Hershow RC, Feinstein DL. Treatment for long acting anticoagulant rodenticide poisoning - beyond INR monitoring? Toxicol Commun. 2018;2(1):59-61. doi: 10.1080/24734306.2018.1500152. PMID: 30923779 Free PMC Article

Huang L, Nikolic D, van Breemen RB. Hepatic metabolism of licochalcone A, a potential chemopreventive chalcone from licorice (Glycyrrhiza inflata), determined using liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2017 Dec;409(30):6937-6948. doi: 10.1007/s00216-017-0642-x. Epub 2017 Nov 10. PMID: 29127460 Free PMC Article

Keiler AM, Macejova D, Dietz BM, Bolton JL, Pauli GF, Chen SN, van Breemen RB, Nikolic D, Goerl F, Muders MH, Zierau O, Vollmer G. Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats. J Steroid Biochem Mol Biol. 2017 Nov;174:234-241. doi: 10.1016/j.jsbmb.2017.09.020. PMID: 28964928 Free PMC Article

Kalinin S, Marangoni N, Kowal K, Dey A, Lis K, Brodsky S, van Breemen R, Hauck Z, Ripper R, Rubinstein I, Weinberg G, Feinstein DL. The Long-Lasting Rodenticide Brodifacoum Induces Neuropathology in Adult Male Rats. Toxicol Sci. 2017 Sep 1;159(1):224-237. doi: 10.1093/toxsci/kfx134. PMID: 28903499 Free PMC Article

Keiler AM, Helle J, Bader MI, Ehrhardt T, Nestler K, Kretzschmar G, Bernhardt R, Vollmer G, Nikolić D, Bolton JL, Pauli GF, Chen SN, Dietz BM, van Breemen RB, Zierau O. A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus. Phytomedicine. 2017 Oct 15;34:50-58. doi: 10.1016/j.phymed.2017.08.001.PMID: 28899509 Free PMC Article

van Breemen R, Betz JM, Evans L, Hall A, Jennens M, Kreider R, Kuszak A, Mudge E, Patel P, Phillips MM, Rimmer CA, Schaneberg BT, Sheshadri A, Solyom AM, Sullivan DM, Szpylka J, Walters DL, White T, Yang J, Young K, Zielinski G, Coates SG. AOAC SMPR 2016.017. J AOAC Int. 2017 Jan 1;100(1):294-296. doi: 10.5740/jaoacint.SMPR2016.017. No abstract available. PMID: 28825562

Dietz BM, Chen SN, Alvarenga RFR, Dong H, Nikolić D, Biendl M, van Breemen RB, Bolton JL, Pauli GF. DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health. J Nat Prod. 2017 Aug 25;80(8):2284-2294. doi: 10.1021/acs.jnatprod.7b00284. PMID: 28812892 Free PMC Article

Li G, Simmler C, Chen L, Nikolic D, Chen SN, Pauli GF, van Breemen RB. Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents. Eur J Pharm Sci. 2017 Nov 15;109:182-190. doi: 10.1016/j.ejps.2017.07.034. Epub 2017 Jul 31. PMID: 28774812 Free PMC Article

Prins GS, Ye SH, Birch L, Zhang X, Cheong A, Lin H, Calderon-Gierszal E, Groen J, Hu WY, Ho SM, van Breemen RB. Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose-Response Analysis. Environ Health Perspect. 2017 Jul 11;125(7):077007. doi: 10.1289/EHP1050. PMID: 28728135 Free PMC Article

Simmler C, Lankin DC, Nikolić D, van Breemen RB, Pauli GF. Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A. Fitoterapia. 2017 Sep;121:6-15. doi: 10.1016/j.fitote.2017.06.017. PMID: 28647482 Free PMC Article

Nikolić D, Macias C, Lankin DC, van Breemen RB. Collision-induced dissociation of phenethylamides: role of ion-neutral complexes. Rapid Commun Mass Spectrom. 2017 Sep 15;31(17):1385-1395. doi: 10.1002/rcm.7915. PMID: 28558170 Free PMC Article

D'Auria L, Reiter C, Ward E, Moyano AL, Marshall MS, Nguyen D, Scesa G, Hauck Z, van Breemen R, Givogri MI, Bongarzone ER. Psychosine enhances the shedding of membrane microvesicles: Implications in demyelination in Krabbe's disease. PLoS One. 2017 May 22;12(5):e0178103. doi: 10.1371/journal.pone.0178103. eCollection 2017. PMID: 28531236 Free PMC Article

Rush MD, Walker EM, Prehna G, Burton T, van Breemen RB. Development of a Magnetic Microbead Affinity Selection Screen (MagMASS) Using Mass Spectrometry for Ligands to the Retinoid X Receptor-α. J Am Soc Mass Spectrom. 2017 Mar;28(3):479-485. doi: 10.1007/s13361-016-1564-0. PMID: 27966173 Free PMC Article

Rush MD, van Breemen RB. Role of ammonium in the ionization of phosphatidylcholines during electrospray mass spectrometry.Rapid Commun Mass Spectrom. 2017 Feb 15;31(3):264-268. doi: 10.1002/rcm.7788. PMID: 27862466 Free PMC Article

Kondratyuk TP, Adrian JA, Wright BJ, Park EJ, van Breemen RB, Morris KR, Pezzuto JM. "Evidence supporting the conceptual framework of cancer chemoprevention in canines.". Scientific reports. 2016;6:26500. doi:10.1038/srep26500.

Hauck ZZ, Feinstein DL, van Breemen RB. "LC-MS-MS Analysis of Brodifacoum Isomers in Rat Tissue.". Journal of analytical toxicology. 2016;40(4):304-9. doi:10.1093/jat/bkw008.

Zhou Q, Chen T, Zhang W, Bozkanat M, Li Y, Xiao L, van Breemen RB, Christman JW, Sznajder JI, Zhou G. "Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis.". American journal of respiratory cell and molecular biology. 2016;54(5):728-39. doi:10.1165/rcmb.2015-0111OC.

Stahlhut RW, van Breemen RB, Gerona RR, Taylor JA, Welshons WV, Vom Saal FS. "Comment on "Optimal Exposure Biomarkers for Nonpersistent Chemicals in Environmental Epidemiology".". Environmental health perspectives. 2016;124(4):A66. doi:10.1289/ehp.1511057.

Imai A, Lankin DC, Nikolić D, Ahn S, van Breemen RB, Farnsworth NR, McAlpine JB, Chen S, Pauli GF. "Cycloartane Triterpenes from the Aerial Parts of Actaea racemosa.". Journal of natural products. 2016;79(3):541-54. doi:10.1021/acs.jnatprod.5b00927.

Kataria Y, Deaton RJ, Enk E, Jin M, Petrauskaite M, Dong L, Goldenberg JR, Cotler SJ, Jensen DM, van Breemen RB, Gann PH. "Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer.". BMC gastroenterology. 2016;16:30. doi:10.1186/s12876-016-0432-5.

Newsome AG, Li Y, van Breemen RB. "Improved Quantification of Free and Ester-Bound Gallic Acid in Foods and Beverages by UHPLC-MS/MS.". Journal of agricultural and food chemistry. 2016;64(6):1326-34. doi:10.1021/acs.jafc.5b04966.

Hauck ZZ, Huang KG, Li G, van Breemen RB. "Determination of bisphenol A-glucuronide in human urine using ultrahigh-pressure liquid chromatography/tandem mass spectrometry.". Rapid communications in mass spectrometry : RCM. 2016;30(3):400-6. doi:10.1002/rcm.7450.