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Micronutrient Information Center

The Glutathione Oxidation Reduction (Redox) Cycle


One molecule of hydrogen peroxide is reduced to two molecules of water, while two molecules of glutathione (GSH) are oxidized in a reaction catalyzed by the selenoenzyme, glutathione peroxidase. Oxidized glutathione may be reduced by the flavin adenine dinucleotide (FAD)-dependent enzyme, glutathione reductase.