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Micronutrient Information Center

Glutathione Oxidation Reduction (Redox) Cycle

One molecule of hydrogen peroxide is reduced to 2 molecules of water while 2 molecules of glutathione (GSH) are oxidized in a reaction catalyzed by the selenoenzyme, glutathione peroxidase. Oxidized glutathione (GSSG) may be reduced by the flavin adenine dinucleotide (FAD)-dependent enzyme, glutathione reductase.